Zur Methodik und klinischen Bedeutung eines neuen Pankreaslipase-Tests mit Fluoresceindilaurinsäureester

Kaffarnik, H; Meyer-Bertenrath, J. G.

doi:10.1007/bf01725679

Cited by 40 publications

(15 citation statements)

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“…13, 29]. The low number of falsenormal results (3 out of 18 cases: 16.6%) could depend on a higher specificity of the substrate, which is specifically broken down by pancreatic arylesterases [9], and seems to be influenced to a lower extent than PABA by extrapancreatic factors. Using cut-off point values as high as 50% for PABA.…”

Section: Discussionmentioning

confidence: 99%

“…During this period of time all the urine was collected and the fluorescein assayed. The relative percent of the urinary excretion of fluorescein (PLt-T/K.%; T = excre tion of dye from fluorescein dilaurate; K = excretion of dye from sodium fluorescein) w-as calculated [9], As far as the values of fluorescein urinary excretion are concerned, we followed the manufacturer's in structions: labelling as abnormal the values below 20%. as normal the values above 30%.…”

Section: Pancreolauryl Test (Plt)mentioning

confidence: 99%

“…The para-aminobenzoic acid (PABA) [2][3][4][5][6][7][8] and the pancreolauryl test [9][10][11][12] are both oral tests and have been proposed in recent years for the study of the exocrine pancreatic function, but few investigations have been carried out comparing these indirect pan creatic function tests with those directly mea-suring the exocrine pancreatic capacity [13,14].…”

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confidence: 99%

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Reliability of the Bz-Ty-PABA and the Pancreolauryl Test in the Assessment of Exocrine Pancreatic Function

Cavallini¹,

Piubello²,

Brocco³

et al. 1983

Digestion

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The reliability of the para-aminobenzoic acid (PABA) test (performed in the conventional manner, i.e. without control day) and of the pancreolauryl test was assayed in respect of the exocrine pancreatic capacity measured by using the secretin-caerulein test in 57 subjects, 22 of which were suffering from chronic pancreatitis. When 50 and 20% urinary excretion of the orally administered Bz-Ty-PABA and pancreolauryl, respectively, were chosen as the lower normal limits, the PABA test showed a specificity quite similar to that of the pancreolauryl test (97 and 95 %, respectively) despite the lack of a control day test, but a lower sensitivity (39 vs. 83%). The association of both tests was not advantageous compared with the pancreolauryl test alone.

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Section: Discussionmentioning

confidence: 99%

Section: Pancreolauryl Test (Plt)mentioning

confidence: 99%

mentioning

confidence: 99%

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Reliability of the Bz-Ty-PABA and the Pancreolauryl Test in the Assessment of Exocrine Pancreatic Function

Cavallini¹,

Piubello²,

Brocco³

et al. 1983

Digestion

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“…The functional pancreatic study included: exocrine function at the 1st and 6th months by means of a pancreolauryl test in urine [20,21], fat in feces (three day stool collection) [22] and fecal chymotrypsin test (Chymo, Roche Diagnostic GmbH, Mannheim, Germany) [23]. At 1 year, the exocrine function by means of indirect tests only in those patients whose previous tests have been pathological and the secretin-pancreozymin test (SPT) [24].…”

Section: Methodsmentioning

confidence: 99%

Exocrine pancreatic changes following acute attack of biliary pancreatitis

Pareja

Artigues

et al. 2002

Pancreatology

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“…To define the frequency of exocrine pancreatic insufficiency in TS and the role of hypoproteinemia and intestinal damage in its development, we analyzed the results of an indirect pancreolauryl test (PT) in TS patients [17, 18]and correlated them with serum albumin levels, degree of intestinal atrophy, and steatorrhea.…”

Section: Introductionmentioning

confidence: 99%

Exocrine Pancreatic Insufficiency in Tropical Sprue

Morales¹,

Galván²,

Mery³

et al. 2001

Digestion

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Background: Pancreatic insufficiency may appear secondary to several intestinal disorders. It may contribute to malabsorption in tropical sprue (TS). Methods: The exocrine pancreatic function was evaluated with the indirect pancreolauryl test (PT) in 56 patients with TS. The PT results were analyzed and correlated with serum albumin levels, degree of intestinal atrophy, and steatorrhea. Results: Abnormally low values were found in 36 (64.2%) cases. A significant relationship was not observed between PT and hypoalbuminemia. Patients with more severe damage by intestinal biopsy tended to have lower PT values. No relationship was found between pancreatic insufficiency and steatorrhea (expressed as g/24 h), but patients with pancreatic insufficiency had increased stool fat concentrations (expressed as percentage of wet stool weight). All patients responded favorably to treatment with folic acid and tetracycline. Fifteen patients with abnormal initial PT values underwent a repeat PT after a 6-week therapy; all of them showed normalization of PT values. Conclusions: The abnormal exocrine pancreatic function found with an indirect test in patients with TS is probably secondary to a low pancreatic hormonal stimulation due to intestinal damage, as occurs in celiac sprue. These abnormalities are reversible after specific treatment for TS.

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Zur Methodik und klinischen Bedeutung eines neuen Pankreaslipase-Tests mit Fluoresceindilaurinsäureester

Cited by 40 publications

References 1 publication

Reliability of the Bz-Ty-PABA and the Pancreolauryl Test in the Assessment of Exocrine Pancreatic Function

Reliability of the Bz-Ty-PABA and the Pancreolauryl Test in the Assessment of Exocrine Pancreatic Function

Exocrine pancreatic changes following acute attack of biliary pancreatitis

Exocrine Pancreatic Insufficiency in Tropical Sprue

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