“…After the administration of synthetic TRH in man, an increase of TSH in plasma is measurable (Bowers, Schally, Hawley, Gual and Parlow 1968, Fleischer, Burgus, Vale, Dunn and Guillemin 1970, Rothenbuchner, Birk, Loos, Goistein, Vanhaelst, Schreiber, Raptis and Pfeiffer 1971, Wagner, Hrubesch, Vosberg, Bäckel, Drisse, Junge-Hülsing and Hauss 1971, Wilber 1970. In addition, an increase of the absolute free thyroxine in plasma after a single injection of synthetic TRH could be confirmed (Wildmeister and Horster 1971).…”