2016
DOI: 10.1016/j.actbio.2016.04.011
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Zwitterionic mesoporous nanoparticles with a bioresponsive gatekeeper for cancer therapy

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Cited by 29 publications
(14 citation statements)
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“…Although the cationic amino groups and anionic carboxyl groups of this copolymer were distributed in the different side chains, they still owned excellent antifouling property, biocompatibility as well as biostability. What’s more, trough linking electric-contrary low-weight molecules to a electroneutral media, researchers have designed a series of mixed-charge pseudo-zwitterionic materials whose characteristics were proved similar to the ordinary zwitterionic ones, some of them were even given novel functions [51] , [52] .…”
Section: Classification Of Zwitterionic Materialsmentioning
confidence: 99%
See 1 more Smart Citation
“…Although the cationic amino groups and anionic carboxyl groups of this copolymer were distributed in the different side chains, they still owned excellent antifouling property, biocompatibility as well as biostability. What’s more, trough linking electric-contrary low-weight molecules to a electroneutral media, researchers have designed a series of mixed-charge pseudo-zwitterionic materials whose characteristics were proved similar to the ordinary zwitterionic ones, some of them were even given novel functions [51] , [52] .…”
Section: Classification Of Zwitterionic Materialsmentioning
confidence: 99%
“…In addition, a great number of mixed-charged zwitterionic materials are designed based on MSNs, which have good biocompatibility, tunable pore sizes, modifiable surface and remarkable drug loading capacity [80] . To improve drug loading efficiency and cellular uptake, a zwitterionic MSN (Z-MSN) was prepared by introducing a composition of carboxylic groups and quaternary amino groups as gatekeepers responding to tumor microenvironment [52] . The surface charge of Z-MSN would switch from negative to positive with cleavage of the acid-sensitive amide linkages, enhancing effective uptake of DOX into tumor issues, leading to much higher antitumor effect compared with free DOX.…”
Section: Applications Of Zwitterionic Materials In Drug Delivery Systmentioning
confidence: 99%
“…In this sense, much research effort is being devoted to design smart DOX-loaded MSNs aimed at overcoming the main limitation of conventional administered DOX in chemotherapy, i.e. its significant systemic toxicity [23,[45][46][47][48][49][50][51]. However, to the best of our knowledge, none of them incorporates stimuli-responsive DOX release and targeting elements to distinguish between healthy and tumor bone cells for the efficient development of targeted bone cancer therapies.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, the nanoparticles showed great biocompatibility with preosteoblasts, assuring their biocompatibility for the treatment of bone infection [176]. Interestingly, this zwitterionic approach using two small molecules can be employed to design pH-responsive gatekeepers by taking advantage of the interaction between both short chains, which interact at physiological pH and experience repulsion forces at acid pH [177].…”
Section: Preventing Protein and Bacterial Adhesion And Biofilm Formatmentioning
confidence: 99%