2023
DOI: 10.1101/2023.09.08.556837
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ZZZ3 protects human embryonic stem cells from nucleolar stress by boosting mTOR/ribosome pathway

Michela Lo Conte,
Valeria Lucchino,
Stefania Scalise
et al.

Abstract: Embryonic stem cells (ESCs) are defined as stem cells with self-renewing and differentiation capabilities. These unique properties are tightly regulated and controlled by complex genetic and molecular mechanisms whose understanding is essential for both basic and translational research. A large number of studies have mostly focused on understanding the molecular mechanisms governing pluripotency and differentiation of ESCs, while the regulation of proliferation has received comparably less attention. In mouse … Show more

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