α-Glucosidase inhibitors from Devil tree (Alstonia scholaris)

Jong-Anurakkun, Nilubon; Bhandari, Megh Raj; Kawabata, Jun

doi:10.1016/j.foodchem.2006.10.043

Cited by 110 publications

(51 citation statements)

References 23 publications

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“…The plant extracts (EAOS and EEOS) also produced decrease in colour intensities in both the in vitro assays suggesting that they also possess inhibitory potential against α-amylase and α-glucosidase enzymes. Previous reports suggest that various potential inhibitors isolated from medicinal plants belong to flavonoid and glycoside class (Lee et al, 2008;Jong et al, 2007). Based on the preliminary phytochemical analysis, we speculate that the presence of flavonoids and glycosides might have contributed to the α-amylase and α-glucosidase inhibitory activity.…”

Section: Charcoal Meal Testmentioning

confidence: 66%

IN VITRO ANTIDIABETIC AND IN VIVO ANTIDIARRHEAL ACTIVITY OF Oncoba Spinosa ROOTS

Suba²,

Bommireddy

et al. 2015

Indonesian J. Pharm.

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The different extracts of Oncoba spinosa (Flacourtiaceae) were screened for in vitro antidiabetic activity. Of all the extracts tested, ethanolic extract showed highest α-amylase inhibition ranging from 8.64+0.66% to 79.94+0.65% and α-glucosidase inhibition ranging from 14.12+0.51% to 78.68+0.36% when studied at concentrations 62.5-1000μg/mL. The ethanolic extract was subjected to antidiarrheal activity and diarrheal severity was reduced significantly by 15.81% in 100mg/kg group, 30.45% in 200mg/kg group and 74.37% in 400mg/kg group in castor oil induced diarrhea model. In castor oil induced enteropooling, the extract at doses 200mg/kg and 400mg/kg showed 33.46% and 42.44% inhibition of intestinal accumulation. In the charcoal meal test, the distance travelled by charcoal meal was significantly reduced by the extract at doses 200mg/kg and 400mg/kg (P<0.01). The overall results tend to suggest the antidiabetic and antidiarrheal activities of Oncoba spinosa.

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Section: Charcoal Meal Testmentioning

confidence: 66%

IN VITRO ANTIDIABETIC AND IN VIVO ANTIDIARRHEAL ACTIVITY OF Oncoba Spinosa ROOTS

Suba²,

Bommireddy

et al. 2015

Indonesian J. Pharm.

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“…Aegeline (2) (18), demethoxycurcumin (19), bisdemethoxycurcumin (20) compounds is a compound that has an anhydroaegeline (4) value of IC 50 = 35.8 mM [19]. Aloe ferox aloe resin contains compound A (11) which has activity in inhibiting intestinal sucrose and maltose in mice with IC 50 = 11.94 mM and IC 50 = 2.16 mM.…”

Section: Natural Productsmentioning

confidence: 99%

“…Aloe ferox aloe resin contains compound A (11) which has activity in inhibiting intestinal sucrose and maltose in mice with IC 50 = 11.94 mM and IC 50 = 2.16 mM. This compound is reported to reduce blood glucose levels in diabetics [20]. Machilus philippinense Merr.…”

Section: Natural Productsmentioning

confidence: 99%

“…The compounds of curcumin (18), demethoxycurcumin (19), and bisdemethoxycurcumin (20), isolated from Curcuma longa (turmeric), have been evaluated in vitro for α-glucosidase inhibitory activity through UV circular dichroism spectroscopy (CD). The results showed that the natural compound bisdemethoxycurcumin showed the remarkable effect of inhibition with IC 50 of 23.0 mM [24].…”

Section: Natural Productsmentioning

confidence: 99%

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Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents

et al. 2017

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“…2) In recent years, many efforts have been made to search for effective -glucosidase inhibitors from natural sources in order to develop a physiological functional food or to discover lead compounds for medicinal usage against diabetes. 3) In the course of our search for rat intestinal -glucosidaseinhibiting principles from various plants, we have isolated and identified several active compounds from plants grown in Asian regions, including Japan, [4][5][6][7] Thailand, 8,9) China, 10,11) and Nepal. 12) In this paper, we present the results of a screening of plants cultivated in Tanegashima, a southern island of Japan, for rat intestinal -glucosidase inhibition.…”

mentioning

confidence: 99%

Methyl Caffeate as an α-Glucosidase Inhibitor fromSolanum torvumFruits and the Activity of Related Compounds

Takahashi

Yoshioka

Kato

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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In screening experiments for rat intestinal -glucosidase (sucrase and maltase) inhibitors in 325 plants cultivated in Japan's southern island, of Tanegashima, marked inhibition against both sucrase and maltase was found in the extract of the fruit of Solanum torvum. Enzyme-assay guided fractionation of the extract led to the isolation of methyl caffeate (1) as a rat intestinal sucrase and maltase inhibitor. We examined 13 caffeoyl derivatives for sucrase-and maltase-inhibitory activities. The results showed that methyl caffeate (1) had a most favorable structure for both sucrase and maltase inhibition, except for a higher activity of methyl 3,4,5-trihydroxycinnamate (14) against sucrase. Its moderate inhibitory action against -glucosidase provides a prospect for antidiabetic usage of S. torvum fruit.Key words: Solanum torvum; -glucosidase inhibitor; methyl caffeate; Tanegashima Diabetes mellitus is one of the most serious chronic diseases. It is caused by continual hyperglycemia and develops along with increases in obesity and aging in the general population. 1) One of the therapeutic approaches to decreasing postprandial hyperglycemia is to retard absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes -amylase and -glucosidase in the digestive organs.2) In recent years, many efforts have been made to search for effective -glucosidase inhibitors from natural sources in order to develop a physiological functional food or to discover lead compounds for medicinal usage against diabetes.3) In the course of our search for rat intestinal -glucosidaseinhibiting principles from various plants, we have isolated and identified several active compounds from plants grown in Asian regions, including Japan, [4][5][6][7] Thailand, 8,9) China, 10,11) and Nepal. 12) In this paper, we present the results of a screening of plants cultivated in Tanegashima, a southern island of Japan, for rat intestinal -glucosidase inhibition. In the screening experiments for rat intestinal sucrase and/or maltase inhibitors in 325 plants, potent sucrase and maltase inhibiting activity was found in extract of the fruit of Solanum torvum (Solanaceae), an edible herbaceous perennial plant. There have been several reports on the chemical constituents of this plant, which include welldocumented steroidal compounds [13][14][15] and antiviral activities, 16) but no other biologically active compounds from this plant have been reported to date. Hence, the promising screening result prompted us to isolate and elucidate the structures of active compounds in this plant. Separation of S. torvum fruit extract using various column chromatographic techniques lead to the isolation of methyl caffeate (1) as one of active principles. Some -glucosidase inhibitors previously isolated from plants contain the caffeoyl moiety as the part of their structure and have been found to be important in exerting inhibitory activity, 3,7) but the contribution of an ester part to the -glucosidase-inhibitory activity of caffeic esters has not been studied. Hence ...

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α-Glucosidase inhibitors from Devil tree (Alstonia scholaris)

Cited by 110 publications

References 23 publications

IN VITRO ANTIDIABETIC AND IN VIVO ANTIDIARRHEAL ACTIVITY OF Oncoba Spinosa ROOTS

IN VITRO ANTIDIABETIC AND IN VIVO ANTIDIARRHEAL ACTIVITY OF Oncoba Spinosa ROOTS

Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents

Methyl Caffeate as an α-Glucosidase Inhibitor fromSolanum torvumFruits and the Activity of Related Compounds

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