α
            <sub>1</sub>
            -Antichymotrypsin Gene (
            <i>SERPINA3</i>
            ) A/T Polymorphism as a Risk Factor for Aneurysmal Subarachnoid Hemorrhage

Słowik, Agnieszka; Borratyńska, Anna; Turaj, Wojciech; Pera, Joanna; Dziedzic, Tomasz; Figlewicz, Denise A.; Betlej, Marek; Krzyszkowski, Tadeusz; Czepko, Ryszard; Szczudlik, Andrzej

doi:10.1161/01.str.0000157598.02014.37

Cited by 24 publications

(19 citation statements)

References 33 publications

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“…The results of the first screening of 147 FIA patients and 139 controls showed a weak significance (p = 0.037) leaning towards a result similar to that described by Slowik et al [2] (p = 0.009) for the genotype model AA versus AT + TT. This encouraged us to proceed by increasing the cohort sizes and, in correlation with the previous report [2], to focus on patients who had suffered a rupture of an IA.…”

Section: Resultssupporting

confidence: 75%

“…Slowik et al [2] found the A15T polymorphism of the SERPINA3 gene to be associated with the risk factor for aneurysmal subarachnoid hemorrhage (SAH) in 180 Polish patients as compared to 263 controls. This polymorphism has been described to be associated with Alzheimer’s disease [3], primary intracerebral hemorrhage [4, 5] and poststroke dementia [6].…”

Section: Introductionmentioning

confidence: 99%

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The Alanine/Threonine Polymorphism of the Alpha-1-Antichymotrypsin (SERPINA3) Gene and Ruptured Intracranial Aneurysms in the Japanese Population

et al. 2006

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Background: Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G. The release of neutrophil cathepsin G (proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. In a previous report there was evidence that an alanine/threonine polymorphism was associated with the risk factor for aneurysmal subarachnoid hemorrhage (SAH) in a Polish population. We performed this study to determine whether this A15T polymorphism shows the same association in a Japanese population. Methods: A total of 437 patients with an aneurysmal SAH and 405 control cases of Japanese origin were genotyped for the A15T polymorphism and 2 further intronic single nucleotide polymorphisms by using polymerase chain reaction and direct sequencing. Results: In the patients with intracranial aneurysms the SERPINA3 A15T allele and genotype distribution did not differ significantly from the controls. Conclusion: In the Japanese population the A15T polymorphism of the SERPINA3 gene is not associated with aneurysmal SAH.

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Section: Resultssupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

The Alanine/Threonine Polymorphism of the Alpha-1-Antichymotrypsin (SERPINA3) Gene and Ruptured Intracranial Aneurysms in the Japanese Population

et al. 2006

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“…A single nucleotide polymorphism (SNP) (rs4934) is located in the signal peptide region (at codon 15) in exon 2. It has been postulated that this genotype affects the expression of serpinA3 protein (12)(13)(14). Moreover, studies have proven that this genetic variant is a risk factor for aneurysmal subarachnoid hemorrhage in a Polish (12), but not in a Chinese (13) or Japanese (14) population.…”

Section: Introductionmentioning

confidence: 99%

Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas

et al. 2011

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Abstract. Proteases facilitate a number of steps in cancer progression. The serine protease inhibitors (serpins) are a protein superfamily with inhibitory activity against proteases. One of these proteases, serpinA3, appears to have a multifaceted role and is associated with inflammatory reactions, Alzheimer's disease, malignant melanoma and gastric cancer. To gain insight into the potential effect of serpinA3 on colorectal cancer (CRC) we determined whether serpinA3 is altered in colorectal tissue or plasma in CRC patients. Collectively, by using ELISA we noted a significantly lower serpinA3 level in cancer tissue compared to paired normal tissue. Moreover, the tumour serpinA3 level tended to be higher in disseminated disease as compared to localised disease. No significant difference in the plasma levels of serpinA3 was noted in the patients when compared to the controls. However, plasma serpinA3 and C-reactive protein (marker of inflammation) in the CRC patients and controls were significantly positively correlated. To confirm and detect localization of serpinA3 expression, immunohistochemistry was performed. Immunohistochemistry showed heterogeneous immunoreactivity in epithelial cells in the cancer and normal tissue and extracellular staining within bands of stroma as well as in some stromal cells. A Taq Man system was used to investigate a single nucleotide polymorphism (rs4934) in the serpinA3 signal sequence gene with supposed effect on serpinA3 secretion and expression. No significant difference was observed between CRC and control subjects regarding genotype and allelic distributions, nor were associations noted between clinical characteristics and serpinA3 levels. In conclusion, an altered serpinA3 concentration in CRC tissue may be a potential biomarker in CRC progression. SerpinA3 concentrations in plasma appear to be correlated with systemic inflammation, but do not appear to be specific to CRC patients. Further studies are warranted to improve our understanding of the role of serpinA3 in CRC.

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“…Επιπλέον, συμμετέχει στη συσσώρευση και την ενεργοποίηση των αιμοπεταλίων, καθώς και στη διάσπαση των παραγόντων πήξης και των πρωτεϊνών της εξωκυττάριας θεμέλιας ουσίας (193). Όλες αυτές οι δράσεις της cat G πιθανόν να καθιστούν το αγγειακό τοίχωμα πιο εύθραυστο και επιρρεπές σε αιμορραγικά γεγονότα (238).…”

Section: Il-1α(-889)unclassified

“…Το Τ αλληλόμορφο του ACT πολυμορφισμού βρέθηκε ότι αυξάνει τον κίνδυνο εμφάνισης ανευρυσματικής υπαραχνοειδούς αιμορραγίας. Η συσχέτιση αυτή αποδόθηκε στην επίδραση της ACT στην αναδιάρθρωση του τοιχώματος των αγγείων και στις φλεγμονώδεις διεργασίες, τα οποία διέπουν το σχηματισμό ανευρυσμάτων (238).…”

Section: Il-1α(-889)unclassified

Γενετική Μελέτη Σε Γονίδια Που Σχετίζονται Με Αγγειακά Εγκεφαλικά Επεισόδια

Δαρδιώτης¹,

Dardiotis²

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α ₁ -Antichymotrypsin Gene ( SERPINA3 ) A/T Polymorphism as a Risk Factor for Aneurysmal Subarachnoid Hemorrhage

Abstract: Background and Purpose-The member 3 of clade A of serine proteinase inhibitors (SERPINA3), known previously as the ␣ 1 -antichymotrypsin, is an acute phase protein, the levels of which increase in acute and chronic inflammation.

Cited by 24 publications

References 33 publications

The Alanine/Threonine Polymorphism of the Alpha-1-Antichymotrypsin (SERPINA3) Gene and Ruptured Intracranial Aneurysms in the Japanese Population

The Alanine/Threonine Polymorphism of the Alpha-1-Antichymotrypsin (SERPINA3) Gene and Ruptured Intracranial Aneurysms in the Japanese Population

Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas

Γενετική Μελέτη Σε Γονίδια Που Σχετίζονται Με Αγγειακά Εγκεφαλικά Επεισόδια

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α 1 -Antichymotrypsin Gene ( SERPINA3 ) A/T Polymorphism as a Risk Factor for Aneurysmal Subarachnoid Hemorrhage

Abstract: Background and Purpose-The member 3 of clade A of serine proteinase inhibitors (SERPINA3), known previously as the ␣ 1 -antichymotrypsin, is an acute phase protein, the levels of which increase in acute and chronic inflammation.

Cited by 24 publications

References 33 publications

The Alanine/Threonine Polymorphism of the Alpha-1-Antichymotrypsin (SERPINA3) Gene and Ruptured Intracranial Aneurysms in the Japanese Population

The Alanine/Threonine Polymorphism of the Alpha-1-Antichymotrypsin (SERPINA3) Gene and Ruptured Intracranial Aneurysms in the Japanese Population

Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas

Γενετική Μελέτη Σε Γονίδια Που Σχετίζονται Με Αγγειακά Εγκεφαλικά Επεισόδια

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α ₁ -Antichymotrypsin Gene ( SERPINA3 ) A/T Polymorphism as a Risk Factor for Aneurysmal Subarachnoid Hemorrhage