α-TCP-based calcium phosphate cements: A critical review

Tronco, Matheus C.; Cassel, Júlia Bünecker; Santos, Luís Alberto Loureiro dos

doi:10.1016/j.actbio.2022.08.040

Cited by 41 publications

(23 citation statements)

References 173 publications

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“…36,37 When the temperature exceeds 1430 °C, the stable phase is α′-TCP, which cannot exist at room temperature. 35 α-TCP and β-TCP are used for bone repair; the crystal structures are shown in Figure 1b. α-TCP is the main component of several hydraulic bone cements, and β-TCP is commonly used for bone scaffolds.…”

Section: Bioactive Ceramicsmentioning

confidence: 99%

“…Meanwhile, the released Ca 2+ can enhance osteoclast mineralization and bone tissue regeneration. − However, HA has high crystallinity and stability, resulting in a slow degradation rate in vivo. , TCP has three polymorphs: α-TCP, α′-TCP, and β-TCP. , β-TCP is stable below 1120 °C and transforms to α-TCP above this temperature. α-TCP is stable between 1120 and 1430 °C and can be retained as a metastable phase at room temperature. , When the temperature exceeds 1430 °C, the stable phase is α′-TCP, which cannot exist at room temperature . α-TCP and β-TCP are used for bone repair; the crystal structures are shown in Figure b.…”

Section: Bioactive Ceramicsmentioning

confidence: 99%

“…α-TCP and β-TCP are used for bone repair; the crystal structures are shown in Figure b. α-TCP is the main component of several hydraulic bone cements, and β-TCP is commonly used for bone scaffolds. , α-TCP has self-curing properties, and the hydrolyzed product is calcium-deficient hydroxyapatite (CDHA), which is easily absorbed in vivo. , However, the degradation rate of α-TCP is too fast, and some studies have shown that α-TCP bone cement was greatly absorbed after 8 weeks. , β-TCP can be resorbed by osteoclasts and has osteotransduction and osteoinduction abilities . However, the sintering efficiency of β-TCP is limited.…”

Section: Bioactive Ceramicsmentioning

confidence: 99%

See 2 more Smart Citations

Comprehensive Review on Fabricating Bioactive Ceramic Bone Scaffold Using Vat Photopolymerization

Liu

Wang

Liu³

et al. 2023

ACS Biomater. Sci. Eng.

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In recent years, bioactive ceramic bone scaffolds have drawn remarkable attention as an alternative method for treating and repairing bone defects. Vat photopolymerization (VP) is a promising additive manufacturing (AM) technique that enables the efficient and accurate fabrication of bioactive ceramic bone scaffolds. This review systematically reviews the research progress of VP-printed bioactive ceramic bone scaffolds. First, a summary and comparison of commonly used bioactive ceramics and different VP techniques are provided. This is followed by a detailed introduction to the preparation of ceramic suspensions and optimization of printing and heat treatment processes. The mechanical strength and biological performance of the VP-printed bioactive ceramic scaffolds are then discussed. Finally, current challenges and future research directions in this field are highlighted.

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Section: Bioactive Ceramicsmentioning

confidence: 99%

Section: Bioactive Ceramicsmentioning

confidence: 99%

Section: Bioactive Ceramicsmentioning

confidence: 99%

See 1 more Smart Citation

Comprehensive Review on Fabricating Bioactive Ceramic Bone Scaffold Using Vat Photopolymerization

Liu

Wang

Liu³

et al. 2023

ACS Biomater. Sci. Eng.

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“…Apart from HA, tricalcium phosphate (TCP) (Ca 3 (PO 4 ) 2 ) is another well-studied 3D printed bioceramic, with α-phase and β-phase. β-TCP has the crystal structure of a rhombohedral space group, exhibiting more stable structure and higher biodegradation rate than those of α-TCP [ 211 , 212 ]. Compared with HA, β-TCP has a faster degradation rate and higher solubility.…”

Section: Functional Engineering Strategies Of Ceramic Materials For H...mentioning

confidence: 99%

Functional engineering strategies of 3D printed implants for hard tissue replacement

Chen

Huang

Liu

et al. 2022

Regenerative Biomaterials

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3D printing technology with the rapid development of printing materials are widely recognized as a promising way to fabricate bioartificial bone tissues. In consideration of the disadvantages of bone substitutes, including poor mechanical properties, lack of vascularization and insufficient osteointegration, functional modification strategies can provide multiple functions and desired characteristics of printing materials, enhance their physicochemical and biological properties in bone tissue engineering. Thus, this review focuses on the advances of functional engineering strategies for 3D printed biomaterials in hard tissue replacement. It is structured as introducing 3D printing technologies, properties of printing materials (metals, ceramics and polymers) and typical functional engineering strategies utilized in the application of bone, cartilage and joint regeneration.

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“…The inherent osteoconductive and osteoinductive properties of CPC make them a great alternative to autografts [ 5 ]. CPC is malleable in nature and can be injected into the defect site to perfectly fill the defect geometry [ 6 ]. Traditional cements are often treated as ticking time bombs as they get hardened before placement in the body and hence need to be injected prior to setting [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Three-Dimensional Printed Copper Loaded Calcium Phosphate Scaffolds for Bone Regeneration

et al. 2023

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Bone regeneration using inorganic nanoparticles is a robust and safe approach. In this paper, copper nanoparticles (Cu NPs) loaded with calcium phosphate scaffolds were studied for their bone regeneration potential in vitro. The pneumatic extrusion method of 3D printing was employed to prepare calcium phosphate cement (CPC) and copper loaded CPC scaffolds with varying wt% of copper nanoparticles. A new aliphatic compound Kollisolv MCT 70 was used to ensure the uniform mixing of copper nanoparticles with CPC matrix. The printed scaffolds were studied for physico-chemical characterization for surface morphology, pore size, wettability, XRD, and FTIR. The copper ion release was studied in phosphate buffer saline at pH 7.4. The in vitro cell culture studies for the scaffolds were performed using human mesenchymal stem cells (hMSCs). The cell proliferation study in CPC-Cu scaffolds showed significant cell growth compared to CPC. The CPC-Cu scaffolds showed improved alkaline phosphatase activity and angiogenic potential compared to CPC. The CPC-Cu scaffolds showed significant concentration dependent antibacterial activity in Staphylococcus aureus. Overall, the CPC scaffolds loaded with 1 wt% Cu NPs showed improved activity compared to other CPC-Cu and CPC scaffolds. The results showed that copper has improved the osteogenic, angiogenic and antibacterial properties of CPC scaffolds, facilitating better bone regeneration in vitro.

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α-TCP-based calcium phosphate cements: A critical review

Cited by 41 publications

References 173 publications

Comprehensive Review on Fabricating Bioactive Ceramic Bone Scaffold Using Vat Photopolymerization

Comprehensive Review on Fabricating Bioactive Ceramic Bone Scaffold Using Vat Photopolymerization

Functional engineering strategies of 3D printed implants for hard tissue replacement

Multifunctional Three-Dimensional Printed Copper Loaded Calcium Phosphate Scaffolds for Bone Regeneration

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