α-Tocopherol protects against α-naphthylisothiocyanate-induced hepatotoxicity in rats less effectively than melatonin

Ohta, Yoshiji; Kongo-Nishimura, Mutsumi; Imai, Yoichiro; Matsura, Tatsuya; Kitagawa, Akira; Yamada, Kazuo

doi:10.1016/j.cbi.2006.03.006

Cited by 19 publications

(40 citation statements)

References 35 publications

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“…The concentration of MDA in the liver was not correlated to absolute vitamin E concentrations, but was correlated to the ratio vitamin E:cholesterol. Studies of MDA concentrations in liver tissue of mice and rats confirm that vitamin E supplementation lowers MDA concentration in liver tissue (Ferre et al, 2001;Ohta et al, 2006). An increase in the ratio of vitamin E:cholesterol also implies a decrease in lipid peroxidation in liver tissue.…”

Section: Mdamentioning

confidence: 95%

The Relationship Between Oxidative Damage and Vitamin E Concentration in Blood, Milk, and Liver Tissue from Vitamin E Supplemented and Nonsupplemented Periparturient Heifers

Bouwstra

Goselink

Dobbelaar

et al. 2008

Journal of Dairy Science

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This study investigated the relationship between oxidative damage and the effect of vitamin E supplementation in blood, milk, and liver tissue in 16 periparturient heifers. The question is whether measurements of oxidative and vitamin E status in blood of a periparturient cow are representative of the total body, given that blood concentrations of both vitamin E and oxidative stress products change around this period. The daily vitamin E intake of the vitamin E-supplemented Holstein-Friesian heifers (n = 8) was 3,000 international units and was started 2 mo before calving; the control heifers (n = 8) were not supplemented. Oxidative damage was determined on the basis of malondialdehyde (MDA) concentrations. Blood was sampled 9 times before calving, on calving day, and twice after calving. Liver biopsies were taken at wk −5, −1, and 2 relative to calving day. Milk was obtained from all heifers immediately after calving, the first 2 milkings and on d 3, 7, and 14 at 0600 h. Serum and liver tissue were analyzed for vitamin E, cholesterol, and MDA; and milk samples were analyzed for vitamin E, MDA, fat, protein, and somatic cell count. The results showed that vitamin E supplements increased both absolute vitamin E concentrations and the ratio of vitamin E to cholesterol in blood and liver tissue. Absolute vitamin E concentration in milk tended to be greater in supplemented cows. Based on the increased MDA blood concentrations at calving, it seems that dairy heifers experience oxidative stress. The effect of vitamin E on MDA differs between the blood, liver, and mammary gland. Vitamin E supplementation could not prevent the increase in blood MDA at calving, but the significantly lower MDA blood concentrations of supplemented cows in the 2 wk after calving suggest that vitamin E has a role in recovery from parturition-related oxidative stress. Vitamin E Received August 9, 2007. Accepted November 25, 2007. 1 Corresponding author: R.J.Bouwstra@vet.uu.nl 977 supplementation reduced oxidative damage in liver, whereas no obvious effect was found on milk MDA concentrations. A strong relationship was found between blood and liver vitamin E and the ratio of vitamin E to cholesterol. Concentrations of MDA in blood and milk were also strongly related. The results show that the relationship between oxidative damage and vitamin E differs within blood, liver tissue, and milk. This implies that oxidative and vitamin E status calculated on the basis of blood values alone should be interpreted with caution and cannot be extrapolated to the whole animal.

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Section: Mdamentioning

confidence: 95%

The Relationship Between Oxidative Damage and Vitamin E Concentration in Blood, Milk, and Liver Tissue from Vitamin E Supplemented and Nonsupplemented Periparturient Heifers

Bouwstra

Goselink

Dobbelaar

et al. 2008

Journal of Dairy Science

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“…Melatonin administration in therapeutic doses showed a significant reduction in all of the measured parameters [117,118]. A comparative study between melatonin and alpha-tocopherol in alpha-naphthyl isothiocyanate-induced hepatotoxicity resulted in a more potent effect of melatonin in terms of antioxidant and antiinflammatory activities [119].…”

Section: Complicationsmentioning

confidence: 99%

Reactive Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the Treatment of Gallstones with Melatonin: A Review

et al. 2008

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Free radical-mediated damage of the gall bladder epithelium predisposes to the development of both gall bladder inflammation and gallstone formation, which often coexist. Melatonin, a pineal and gut secretory product, due to its antioxidant activity along with its effect on the aging gall bladder myocytes, inhibits gallstone formation. Melatonin reduces the biliary levels of cholesterol by inhibiting cholesterol absorption across the intestinal epithelium and by increasing the conversion of cholesterol to bile acids. The incidence of gallstones is increasing and is expected to rise dramatically with the increase in the longevity and the risk factors such as obesity. The change in the prevalence of cholelithiasis is associated with a proportionate rise in the incidence of cholangiocarcinoma. In an attempt to improve the quality of life of the rapidly increasing aging population, this article reviews up-to-date information on the pathophysiology of the gall bladder function and discusses the development of new therapies with potential good patient compliance and lower cost than the current treatments.

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“…It is known that MT protects against ANIT-induced acute liver injury with cholestasis in rats by exerting its antioxidant and anti-inflammatory actions [5,8]. It is also known that orally administered MT reduces an increase in serum T-Chol concentration in rats with ANITinduced acute liver injury with cholestasis [5].…”

Section: Introductionmentioning

confidence: 98%

“…In ANIT-treated rats, increases in total cholesterol (T-Chol) and free cholesterol (F-Chol) concentrations as well as phospholipid concentration and a decrease in the ratio of esterified cholesterol (E-Chol) concentration to F-Chol concentration (E-Chol/F-Chol) in the plasma or serum occur with the appearance of cholestasis [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Aberrations in lipid and lipoprotein metabolism have been reported in rats and mice with alpha-naphthylisothiocyanate (ANIT)-induced acute liver injury with cholestasis [1][2][3][4][5][6]. In ANIT-treated rats, increases in total cholesterol (T-Chol) and free cholesterol (F-Chol) concentrations as well as phospholipid concentration and a decrease in the ratio of esterified cholesterol (E-Chol) concentration to F-Chol concentration (E-Chol/F-Chol) in the plasma or serum occur with the appearance of cholestasis [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Effect of melatonin on serum cholesterol status with formation of alpha-naphthylisothiocyanate-induced liver injury in rats

Ohta

Imai

Kitagawa

2007

International Congress Series

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α-Tocopherol protects against α-naphthylisothiocyanate-induced hepatotoxicity in rats less effectively than melatonin

Cited by 19 publications

References 35 publications

The Relationship Between Oxidative Damage and Vitamin E Concentration in Blood, Milk, and Liver Tissue from Vitamin E Supplemented and Nonsupplemented Periparturient Heifers

The Relationship Between Oxidative Damage and Vitamin E Concentration in Blood, Milk, and Liver Tissue from Vitamin E Supplemented and Nonsupplemented Periparturient Heifers

Reactive Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the Treatment of Gallstones with Melatonin: A Review

Effect of melatonin on serum cholesterol status with formation of alpha-naphthylisothiocyanate-induced liver injury in rats

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