α-Tricalcium phosphate cement: “in vitro” cytotoxicity

Santos, Luís Alberto dos; Carrodeguas, Raúl García; Rogero, Sizue Ota; Higa, Olga Zazuco; Boschi, Anselmo O.; Arruda, Antônio Celso Fonseca de

doi:10.1016/s0142-9612(01)00333-7

Cited by 69 publications

(52 citation statements)

References 17 publications

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“…For both cements the values obtained using the Gilmore Needles 19 were higher when compared to the values reported on the literature 20,21 . Initial setting time was 15 minutes for α-TCP and 30 minutes for Si-α-TCP.…”

Section: Resultscontrasting

confidence: 58%

Si-TCP synthesized from "Mg-free" reagents employed as calcium phosphate cement

Motisuke

Carrodeguas²,

Zavaglia

2012

Mat. Res.

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The influence of silicon doping on calcium phosphate cement were explored in this work. α-TCP and Si-α-TCP were prepared by solid state reaction employing "Mg-free" CaHPO 4 , CaCO 3 and CaSiO 3 as precursors. It was possible to obtain TCP powders with low contents of β phase as contaminant. Cement liquid phase was an aqueous solution containing 2.5 wt. (%) of Na 2 HPO 4 and 1.5 wt. (%) of citric acid. The liquid-to-powder ratio was 0.6 mL.g -1. Chemical, physical and mechanical properties of the cement samples were determined by means of XRD, FTIR, XRF, compressive strength and SEM. The calcium phosphate cements obtained achieved satisfactory properties; however, Si-α-TCP presented a decrease on the rate of setting reaction.

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Section: Resultscontrasting

confidence: 58%

Si-TCP synthesized from "Mg-free" reagents employed as calcium phosphate cement

Motisuke

Carrodeguas²,

Zavaglia

2012

Mat. Res.

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“…Studies have proven that combining PRP with biomaterials optimizes and accelerates the bone tissue regeneration process (38) . The histological analyses also demonstrated that there was no inflammatory response or necrosis in any of the animals, and this is concordant with studies that aimed to assess the biocompatibility of α-TCP cement (39,40) . Another possible explanation for the absence of inflammation or bone necrosis is that saline solution was used to constantly irrigate the surgical field while the defects were being created, and that both the cement and the surgical materials used in all the procedures had been sterilized.…”

Section: Discussionsupporting

confidence: 85%

Estudo comparativo do uso isolado de plasma rico em plaquetas e combinado com cimento de alfa-fosfato tricálcico no reparo ósseo em ratos

Sebben¹,

Hoff²,

Klein³

et al. 2012

Rev. bras. ortop.

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Objectives: To evaluate the effect of alpha-tricalcium phosphate (α-TCP) cement combined with platelet-rich plasma (PRP) on osteogenesis, and to compare the results with use of PRP alone. Methods: A bilateral defect was produced in rat femurs and was filled with one of two types of treatments (PRP or α-TCP + PRP). The outcomes were evaluated after four and eight weeks. Radiographic images provided values for the lesion area, and histology (picrosirius staining) indicated the area of new bone formation. Results: The means relating to the lesion area of the α-TCP + PRP group (2.64 ± 2.07 and 1.91 ± 0.93 mm², after four and eight weeks, respectively) showed numerically better Rev Bras Ortop. 2012;47(4):505-12The authors declare that there was no conflict of interest in conducting this work this article is available online in Portuguese and English at the websites: www.rbo.org.br and www.scielo.br/rbort but non-significant results (p > 0.05) than those seen in the PRP group (5.59 mm ² ± 2.69 and 3.23 ± 1.46 mm ², after four and eight weeks, respectively). The mean new bone formation rates were 62.7% ± 12.1 and 79.01% ± 6.25 in the PRP group, and 73.3% ± 12.7 and 85.86% ± 10.45 in α-TCP + PRP group, after four and eight weeks, respectively (p > 0.05). Conclusion: The data from this study suggest that treatment with α-TCP cement combined with PRP does not show any significant difference in comparison with PRP alone. However, there is a possible early effect on bone regeneration when the two biomaterials are applied together.

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“…O pó do cimento de α-TCP foi sintetizado em laboratório utilizando-se a metodologia reportada por Driessens (1997), reagindo-se carbonato de cálcio (CaCO 3 ) (Nuclear ® ) e pirofosfato de cálcio (Ca 2 P 2 O 7 -γ) (VETEC ® Química Fina) durante 15h a 1300ºC seguido de resfriamento brusco [9]. O material foi então desagregado em almofariz de porcelana e submetido a 6h de moagem úmida em frasco plástico contendo álcool etílico, com esferas de zircônia.…”

Section: Preparação Do Tcpunclassified

Influência de aditivos na injetabilidade de cimento ósseo de fosfato tricálcico

2006

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RESUMOOs cimentos de fosfatos de cálcio são biomateriais formados pela mistura de um pó de fosfato de cálcio com água ou com solução aquosa de sais orgânicos ou inorgânicos formando uma pasta que reage à temperatura ambiente ou corpórea, endurecendo como resultado da reação de precipitação. Cimentos de fosfato de cálcio são usados comumente em cirurgias de preenchimento ósseo na odontologia e ortopedia, que requerem procedimentos extremamente invasivos. A inovação consiste em formular uma pasta injetável pela incorporação de aditivos. Neste estudo, três aditivos (carboxi-metil-celulose, polímero de agar e alginato de sódio) foram incorporados a fosfato tricálcico-alfa, nas concentrações de 0,4%; 0,8%; 1,6%; 3,2%; 6,4% em massa. Os resultados demonstraram que foi possível obter composições de cimento de fosfato tricálcico injetáveis. Verificou-se que a injetabilidade, medida por um método inédito proposto, depende do comportamento reológico das pastas. Neste estudo, as formulações com 1,6% de carboxi-metil-celulose, 1,6% de agar e 0,8% de alginato de sódio, permitiram a obtenção de uma viscosidade suficiente para uma boa homogeneização e injeção do cimento.Palavras chaves: Cimento ósseo, fosfato tricálcico, aditivos, injetabilidade. Additives Influence on the Injectability of Tricalcium Phosphate Bone Cement ABSTRACTCalcium phosphate cements are biomaterials made of a mixture of calcium phosphate powder with water or with aqueous solutions of inorganic or organic salts, forming a paste that reacts at room or body temperature and hardens as a result of precipitation reactions. Calcium phosphate cements are commonly used in both dentistry and orthopedic bone filling surgeries, which require extremely invasive procedures. The innovation consists in formulate an injectable paste by incorporation of additives. In this work, three different additives (carboxymethylcellulose, agar polymer and calcium alginate) were incorporated in alphatricalcium phosphate (α-TCP), in concentrations of 0.4%; 0.8%; 1.6%; 3.2% and 6.4% wt%. Results showed that it was possible to obtain injectable compositions of tricalcium phosphate cement. It was verified that the injectability, measured by a novel method, depends on the rheological behavior of the pastes and injection time. In this study, pastes with sufficient viscosity for good homogenization and injection were obtained. In this study, pastes with 1.6% carboxymethylcellulose, 1.6% agar and 0.8% sodium alginate present sufficient viscosity for good homogenization for cement injection.

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α-Tricalcium phosphate cement: “in vitro” cytotoxicity

Cited by 69 publications

References 17 publications

Si-TCP synthesized from "Mg-free" reagents employed as calcium phosphate cement

Si-TCP synthesized from "Mg-free" reagents employed as calcium phosphate cement

Estudo comparativo do uso isolado de plasma rico em plaquetas e combinado com cimento de alfa-fosfato tricálcico no reparo ósseo em ratos

Influência de aditivos na injetabilidade de cimento ósseo de fosfato tricálcico

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