α1- and β-Adrenoblockers Effects on Immunogenesis in Rats under Thermoneutral Conditions and after Cooling of Various Extent

Eliseeva, L. S.; Chramova, G. M.; Gonsales, E. B.; Козырева, Т. В.

doi:10.1007/s10517-009-0476-4

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…A lowered core body temperature in rats significantly reduces splenic antigen-binding and the number of antigen-producing cells. 34 Mice exposed to cold temperatures exhibit increased adrenal cortisol concentration, decreased NK cell numbers, and cytotoxicity. [35][36][37] Interestingly, blocking norepinephrine receptors can restore NKCA, again indicating a large role for norepinephrine.…”

Section: Immune Responsesmentioning

confidence: 99%

Immune Responses to Exercising in a Cold Environment

LaVoy

McFarlin

Simpson

2011

Wilderness & Environmental Medicine

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Cold temperature and exercise independently impose stress on the human body that can lead to circulatory and metabolic changes, and depress the immune system. Multiple stressors applied together may amplify this immunodepression, causing greater immune impairment and heightened infection risk than with either stressor alone. As such, winter athletes and other persons who work or physically exert themselves in cold temperatures may have greater levels of stress-induced immune impairment than would be expected under mild temperatures. This review examines the literature regarding changes to physiological and immunological parameters arising from exposure to cold temperatures and to exercise. Even brief exposure to cold leads to increased levels of norepinephrine and cortisol, lymphocytosis, decreased lymphoproliferative responses, decreased levels of TH1 cytokines and salivary IgA, and increased lactate levels during exercise. Whether these changes lead to increased susceptibility to infection, as suggested by some epidemiological reports, remains to be determined. Although there is some evidence that exercising in temperatures near 5°C leads to greater immune impairment compared to exercising in milder temperatures, there is a need to explore the effects of exercise on immunity in the subfreezing conditions typically encountered by winter athletes. This is required to fully determine the extent to which performing vigorous exercise in subfreezing temperatures amplifies exercise-induced immune impairment and infection risk.

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Section: Immune Responsesmentioning

confidence: 99%

Immune Responses to Exercising in a Cold Environment

LaVoy

McFarlin

Simpson

2011

Wilderness & Environmental Medicine

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“…It can be assumed that when stimulating of TRPM8 in nerve endings with menthol, similarly to the stimulation of this ion channel by cold, the activation of the sympathetic nervous system takes place, which in turn activates spleen cells. It is known that the activity of T cells is closely related to the activity of the sympathetic nervous system [33,34], the increase in activity of the sympathetic system under the influence of cold is well known [35,36] and the nerve fibers, on which the TRPM8 ion channel is localized, are those afferents that initiate all events associated with exposure to cold. The effect of menthol activated directly on spleen immune cells leads to stimulation of TRPM8, which is a calcium channel [11,37], provides entry into the cell of calcium ions, and can promote the activation of surface receptors binding antigens.…”

Section: Discussionmentioning

confidence: 99%

TRPM8 ion channel in neuro-immune regulation of antigen binding function of spleen cells

Tv¹,

Ls²,

Gm³

et al. 2019

Trends Med

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Ion channels, localized in cells with different specialization, may participate in the performance of various functions. In the experiments on rats, quantitative PCR has shown that spleen cells express the genes of thermosensitive TRP ion channels (TRPV1, TRPV2, TRPV3, TRPV4, TRPM8, and TRPA1). Experiments in vitro with the addition of an agonist of the TRPM8 ion channel menthol (10 -5 M and 10 -8 M) to the incubation medium indicate the presence of the TRPM8 on immune cells, and its stimulatory effect on the antigen binding, the number of rosette-forming cells doubles under the influence of menthol at concentration of 10 -8 M. Stimulation of the TRPM8 ion channel localized in the skin nerve afferents by menthol (1% L-menthol) also has a stimulating effect on the antigen-binding function of spleen cells without interfering with the additional stimulation of this function when exposed to the TRPM8 agonist directly on spleen cells. The obtained results testify to the important role of the TRPM8 ion channel of different localization (in spleen cells and in the peripheral sensory neurons) in the regulation of the antigen binding function in the spleen. This indicates new moments of the neuro-immune interaction.

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Development of Research on the Thermoregulatory System in Russia

Козырева

2022

Thermal Physiology

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α1- and β-Adrenoblockers Effects on Immunogenesis in Rats under Thermoneutral Conditions and after Cooling of Various Extent

Cited by 9 publications

References 8 publications

Immune Responses to Exercising in a Cold Environment

Immune Responses to Exercising in a Cold Environment

TRPM8 ion channel in neuro-immune regulation of antigen binding function of spleen cells

Development of Research on the Thermoregulatory System in Russia

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