α2δ1 may be a potential marker for cancer stem cell in laryngeal squamous cell carcinoma

Huang, Chaoping; Li, Yan; Zhao, Wei; Zhang, Aobo; Lu, Cheng Hsien; Wang, Zhenxiao; Liu, Liangfa

doi:10.3233/cbm-181947

Cited by 13 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other types of cancer also contain a subset of α2δ1+ cells (small-cell lung cancer, laryngeal squamous cell carcinoma and gastric cancer), showing not only the same stem cell-like properties [197], but also the same chemoresistant phenotype [198] and overexpression of ERK1/2 [199]. In all cases, inhibition of α2δ1 has been proposed as a new promising therapeutic target for CSCs, including HCC CSCs [197][198][199][200].…”

Section: Mechanisms Of Resistance To Therapy Of Cscsmentioning

confidence: 99%

The Cancer Stem Cell in Hepatocellular Carcinoma

Schulte

López-Gil

Sáinz

et al. 2020

Cancers

View full text Add to dashboard Cite

The recognition of intra-tumoral cellular heterogeneity has given way to the concept of the cancer stem cell (CSC). According to this concept, CSCs are able to self-renew and differentiate into all of the cancer cell lineages present within the tumor, placing the CSC at the top of a hierarchical tree. The observation that these cells—in contrast to bulk tumor cells—are able to exclusively initiate new tumors, initiate metastatic spread and resist chemotherapy implies that CSCs are solely responsible for tumor recurrence and should be therapeutically targeted. Toward this end, dissecting and understanding the biology of CSCs should translate into new clinical therapeutic approaches. In this article, we review the CSC concept in cancer, with a special focus on hepatocellular carcinoma.

show abstract

Section: Mechanisms Of Resistance To Therapy Of Cscsmentioning

confidence: 99%

The Cancer Stem Cell in Hepatocellular Carcinoma

Schulte

López-Gil

Sáinz

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…Other authors showed that there were other types of cancer that contain α2δ1+ cells such as small-cell lung cancer, laryngeal squamous cell carcinoma, and gastric cancer, with nearly the same stem cell-like properties [12], resistant to chemotherapy [13], and overexpression of ERK1/2 [14]. Also, they showed that inhibition of α2δ1 may serve as a new promising therapeutic target for these CSCs [15,16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of diagnostic accuracy of serum calcium channel α2δ1 subunit in hepatocellular carcinoma-related cirrhosis

Ahmed

Bayoumi

Khayyal

et al. 2020

Egypt Liver Journal

View full text Add to dashboard Cite

Background: Hepatocellular carcinoma (HCC) is one of the commonest malignancies worldwide that carries a bad prognosis particularly in Egypt due to the high prevalence of HCV burden. Late diagnosis of HCC especially in cirrhosis suffering-liver is one of the causes that worsen HCC outcome. Identification of molecular pathways of HCC will open the gate for early diagnosis and effective management. Oscillation of calcium controlled by the α2δ1 subunit has been proposed as one of the mechanisms in tumor-initiating cell properties of HCC. In this study, we aim to evaluate the serum α2δ1 subunit level as a biological marker for HCC. A total of 90 participants were enrolled, 40 patients with HCC, 40 patients with cirrhosis, and 10 healthy volunteers; serum level of α2δ1 was assessed in all participants with ELISA Results: The mean serum levels of α2δ1 were significantly higher in HCC group (19.53 ± 6.87 ng/dL) than cirrhotic (6.24 ± 2.64 ng/dL) and control groups (0.67 ± 0.48 ng/dL) (P = 0.001). There was no significance between α2δ1 and etiology of liver disease as viral (HCV, HBV) or non-viral (P = 0.14). Conclusion: α2δ1 subunit may serve as a potential non-invasive marker with excellent sensitivity for diagnosis of HCC regardless of the etiology of liver disease.

show abstract

“…In 2010, García et al [147] reported that when the expression of calcium channel α2δ1 subunit was inhibited, migration, adhesion as well as spreading of myoblasts were impaired, whereas the L-type calcium maintained unaffected, suggesting a newfound function of the α2/δ1 subunit in extracellular signaling. Later studies have confirmed that calcium channel α2/δ1 subunit is a potential marker for CSCs in laryngeal squamous cell carcinoma [148] and in non-small cell lung cancer [149] . Zhao et al [11] identified α2/δ1 subunit as a LCSCs marker and developed its monoclonal antibody named 1B50-1, which had positive therapeutic effects on HCC xenograft by eradicating LCSCs.…”

Section: α2δ1mentioning

confidence: 89%

Advances in surface markers of liver cancer stem cell

Zhang¹,

Gong²,

Yan³

et al. 2019

View full text Add to dashboard Cite

Liver cancer stem cells (LCSCs), a small subpopulation that constitutes liver cancer heterogeneity, play a vital role in cancer initiation, invasion, recurrence, metastasis, and resistance to chemo-radiotherapy. It is believed that therapies targeting LCSCs can improve the efficacy of conventional chemotherapy and radiotherapy by completely eliminating tumors while preventing recurrence. Therefore, during last decades, numerous surface markers for LCSCs have been identified and characterized in many subtypes of liver cancer, especially in hepatocellular carcinoma (HCC). These well-recognized surface markers significantly promote the therapeutic efficacy that identifies, targets and destroys LCSCs. Meanwhile, there have been intensive studies that aim to investigate the molecular mechanism of how stemness contributes to liver cancer relapse, recurrence and resistance. However, liver cancer stemness seems to be regulated by a hierarchical organization and crosstalk of a wide variety of signaling pathways. Using individual or few LCSC surface markers may not be able to completely reveal the intrinsic stemness hierarchy. From an integrated perspective, understanding of recent advances in LCSC surface markers remains important and urgent. In this review, we concentrate on demonstrating the indispensable roles of LCSC surface markers in identification and characterization of multiple cancer stages including initiation, invasion, metastasis, resistance and highlighting the cutting-edge therapeutic strategies against cancer stem cells in HCC.

show abstract

α2δ1 may be a potential marker for cancer stem cell in laryngeal squamous cell carcinoma

Cited by 13 publications

References 31 publications

The Cancer Stem Cell in Hepatocellular Carcinoma

The Cancer Stem Cell in Hepatocellular Carcinoma

Evaluation of diagnostic accuracy of serum calcium channel α2δ1 subunit in hepatocellular carcinoma-related cirrhosis

Advances in surface markers of liver cancer stem cell

Contact Info

Product

Resources

About