β‐Adrenergic Agonist Hyperplastic Effect Is Associated with Increased Fibronectin Gene Expression and Not Mitogen‐Activated Protein Kinase Modulation in C2C12 Cells
Abstract:Abstract. β‐Adrenergic agonists (β‐AA) enhance protein accretion in skeletal muscles. This stimulation is characterized by increased protein synthesis, increased expression of myofibrillar protein genes and a depression in protein degradation in animals, and increased proliferation and DNA synthesis in muscle cells in vitro. The mechanism or signal path in muscle whereby β‐AA would elicit these physiological effects upon binding to the G protein–coupled β‐adrenergic receptor (β‐AR) is unclear. C2C12 myoblasts … Show more
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