2021
DOI: 10.1101/2021.03.18.436000
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β-Carotene oxidation products - function and safety

Abstract: Abstractβ-Carotene oxidation products have newly discovered bioactivity in plants and animals. Synthetic fully oxidized β-carotene (OxBC) has application in supporting livestock health, with potential human applications. The safety of synthetic OxBC has been evaluated. An Ames test showed weak-to-moderate mutagenicity in only one cell line at high concentrations. A mouse micronucleus assay established a non-toxic dose of 1800 mg/kg body weight, and no bone marrow micronuclei were induced. Plant sources of β-ca… Show more

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Cited by 1 publication
(2 citation statements)
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“…β-carotene (C 40 H 56 , β, β -carotene Figure 1 A) is a fatty-soluble carotenoid with two retinyl groups and eleven conjugated double bonds. The molecular structure endows β-carotene relatively strong provitamin A and antioxidant activities ( Watkins and Pogson, 2020 ; Burton et al., 2021 ). Given these excellent properties, β-carotene has been widely applied in many industries, such as medicine ( Novikov et al., 2022 ), nourishments ( Burton et al., 2021 ; Hambly et al., 2021 ), food additives ( Barbosa et al., 2021 ), cosmetics ( Borja-Martínez et al., 2020 ), and feed additives ( Mudronova et al., 2018 ).…”
Section: Characteristics Of Carotenoid Biosynthesis By R Mu...mentioning
confidence: 99%
See 1 more Smart Citation
“…β-carotene (C 40 H 56 , β, β -carotene Figure 1 A) is a fatty-soluble carotenoid with two retinyl groups and eleven conjugated double bonds. The molecular structure endows β-carotene relatively strong provitamin A and antioxidant activities ( Watkins and Pogson, 2020 ; Burton et al., 2021 ). Given these excellent properties, β-carotene has been widely applied in many industries, such as medicine ( Novikov et al., 2022 ), nourishments ( Burton et al., 2021 ; Hambly et al., 2021 ), food additives ( Barbosa et al., 2021 ), cosmetics ( Borja-Martínez et al., 2020 ), and feed additives ( Mudronova et al., 2018 ).…”
Section: Characteristics Of Carotenoid Biosynthesis By R Mu...mentioning
confidence: 99%
“…The molecular structure endows β-carotene relatively strong provitamin A and antioxidant activities ( Watkins and Pogson, 2020 ; Burton et al., 2021 ). Given these excellent properties, β-carotene has been widely applied in many industries, such as medicine ( Novikov et al., 2022 ), nourishments ( Burton et al., 2021 ; Hambly et al., 2021 ), food additives ( Barbosa et al., 2021 ), cosmetics ( Borja-Martínez et al., 2020 ), and feed additives ( Mudronova et al., 2018 ). Moreover, β-carotene has also been used to prevent cancer, tumors ( Lee et al., 2022 ), and cardiovascular disease in medical and health-care proposals ( Yang et al., 2022 ).…”
Section: Characteristics Of Carotenoid Biosynthesis By R Mu...mentioning
confidence: 99%