β-Cyclodextrin-based metal-organic framework as a carrier for zero-order drug delivery

Li, Yanyi; Huang, Haobin; Ding, Chong-Wei; Zhou, Xiao‐Ping; Li, Hong

doi:10.1016/j.matlet.2021.129766

Cited by 27 publications

(12 citation statements)

References 8 publications

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“…For delayed drug release, anionic β-CyD polymers bearing carboxylate residues are useful [92]. Metal complexes of CyD [93] and metalorganic frameworks (MOFs) containing CyDs [94][95][96] were also developed for DDSs.…”

Section: Cyd-based Nanoarchitectures To Promote Photothermal Therapymentioning

confidence: 99%

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

Komiyama¹

2023

Beilstein J. Nanotechnol.

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Cyclodextrins have been widely employed for drug delivery systems (DDSs) in which drugs are selectively delivered to a target site in the body. Recent interest has been focused on the construction of cyclodextrin-based nanoarchitectures that show sophisticated DDS functions. These nanoarchitectures are precisely fabricated based on three important features of cyclodextrins, namely (1) the preorganized three-dimensional molecular structure of nanometer size, (2) the easy chemical modification to introduce functional groups, and (3) the formation of dynamic inclusion complexes with various guests in water. With the use of photoirradiation, drugs are released from cyclodextrin-based nanoarchitectures at designated timing. Alternatively, therapeutic nucleic acids are stably protected in the nanoarchitectures and delivered to the target site. The efficient delivery of the CRISPR-Cas9 system for gene editing was also successful. Even more complicated nanoarchitectures can be designed for sophisticated DDSs. Cyclodextrin-based nanoarchitectures are highly promising for future applications in medicine, pharmaceutics, and other relevant fields.

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Section: Cyd-based Nanoarchitectures To Promote Photothermal Therapymentioning

confidence: 99%

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

Komiyama¹

2023

Beilstein J. Nanotechnol.

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“…Also, β-CD-MOFs were synthesized for the delivery of the flavonoid Naringin, used as a model. 200 The double channel structures in the β-CD-MOF bind the drug effectively and ensure its slow release over a period of one month by following zero-order kinetics, the latter being one of the most critical strategies in pharmaceutical technology. Moreover, core–shell structures have been synthesized which exhibit retarded release of the loaded components.…”

Section: Applications Of Cd-mof Based Materialsmentioning

confidence: 99%

Cyclodextrin metal–organic frameworks and derivatives: recent developments and applications

et al. 2022

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“…Hence, CD MOF nanocarriers are favored for drug loading and release in the therapeutic field. Recently, more attention has been focused on the development of nanoscale CD MOFs for controlled drug delivery and release [130][131][132][133][134][135][136][137][138][139][140].…”

Section: Mofsmentioning

confidence: 99%

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

et al. 2022

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Metal–organic frameworks (MOFs) have a good designability, a well-defined pore, stimulus responsiveness, a high surface area, and a controllable morphology. Up to now, various MOFs have been widely used as nanocarriers and have attracted lots of attention in the field of drug delivery and release because of their good biocompatibility and high-drug-loading capacity. Herein, we provide a comprehensive summary of MOF-based nanocarriers for drug delivery and release over the last five years. Meanwhile, some representative examples are highlighted in detail according to four categories, including the University of Oslo MOFs, Fe-MOFs, cyclodextrin MOFs, and other MOFs. Moreover, the opportunities and challenges of MOF-based smart delivery vehicles are discussed. We hope that this review will be helpful for researchers to understand the recent developments and challenges of MOF-based drug-delivery systems.

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β-Cyclodextrin-based metal-organic framework as a carrier for zero-order drug delivery

Cited by 27 publications

References 8 publications

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

Cyclodextrin metal–organic frameworks and derivatives: recent developments and applications

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

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