β-Cyclodextrin-folate functionalized poly(lactic-co-glycolide)–superparamagnetic ytterbium ferrite hybrid nanocarrier for targeted delivery of camptothecin

Kaliyamoorthy, Kiruthiga; Pillai, Archana Sumohan; Alexander, Aleyamma; Arivarasu, Anitha; Enoch, Israel V.M.V.; Ramasamy, Sivaraj

doi:10.1016/j.msec.2020.111796

Cited by 23 publications

(6 citation statements)

References 34 publications

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“…CPT forms an inclusion complex with the β-CD molecule. 32 Therefore, the poly-CD is a suitable choice to be employed as the polymeric host structure that is immobilized on the surface of the NPs. The CPT release pro le from the nanocarrier (Fig.…”

Section: Drug-loading and Releasementioning

confidence: 99%

Camptothecin-Carrying Cuco2s4 Nanoparticles: Sustained Drug Release And Anticancer Activity

Pillai

Alexander

Manikantan

et al. 2021

Preprint

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Nanocarriers of anticancer drugs are delicately designed with precision addition at every attempt. In this paper, we report CuCo2S4 nanoparticles that show light-absorption in the NIR-II wavelength range and possess magnetic characteristics. The synthesized nanoparticles are characterized employing XRD, SEM, DLS, TGA, and XPS methods. The nanoparticles form a composite with biocompatible polymeric β-cyclodextrin. The nanoparticles possess a band gap energy of 2.25 eV. The magnetic property arises due to the cobalt-incorporation in the nanoparticles. The anticancer drug, camptothecin, is loaded in the nanocarrier with an 89% adsorption efficiency. The in vitro release of the drug occurs in a sustained fashion. Further, the in vitro anticancer potential of the nanocarrier is examined on breast cancer (MDA=MB-231) cell lines and the activities of the free- and the drug-loaded nanocarrier are compared. The cobalt-containing copper sulfide nanoparticle-poly-β-cyclodextrin composite works as a promising nanocarrier of camptothecin.

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Section: Drug-loading and Releasementioning

confidence: 99%

Camptothecin-Carrying Cuco2s4 Nanoparticles: Sustained Drug Release And Anticancer Activity

Pillai

Alexander

Manikantan

et al. 2021

Preprint

Self Cite

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“…Nanoparticles with sizes smaller than 10 nm lead to renal filtration and accumulation into the fenestration of the kidneys' glomerular endothelium. Therefore, the most effective drug delivery agents possess sizes ranging between 10 and 100 nm [68]. However, Sivaraj et al [69] suggest that the nuclear membrane pores allow entry of nanoparticles with a size below 9 nm.…”

Section: Figurementioning

confidence: 99%

“…The performance enhancement achieves through functionalization with suitable ligands that will bind to the aimed receptors of pathological tissues. The size of the nanocarrier has paramount importance for rendering it absorbable by tumor tissues [68]. The inclusion of active targeting functionalities results in drug accumulation within tumors, tumor cells, or immune cells and allows for reduced dosages due to specificity.…”

Section: Nanoferrites Functionalized and Functional Groups For Drug Delivery In Cancermentioning

confidence: 99%

“…The nanoferrites can magnetically remove from the solution instead of the centrifugation process. The maximum wavelength for anticancer drugs are: Doxorubicin at 479 nm [23], Curcumin at 425 nm [34], Camptothecin at 480 nm, [68], 5-Fluorouracil at 266 nm [21], Cisplatin at 300 nm [18], Imanitib at 260 nm [31], Telmisartan at 296 nm [20], and Tamoxifen at 250 nm [55].…”

Section: Drugs Loaded On Functionalized Nanoferrites For Cancer Treatmentsmentioning

confidence: 99%

“…Conventional drug delivery methods rely on the absorption of drugs and transport across biological membranes through diffusion and systemic transport. The targeted drug delivery, on the contrary, focuses on enhancing the concentration of the chemotherapeutic drug in the disease parts of the body [87]. The drug release studies, usually, are realized in simulated physiological conditions and measured by HPLC [30] or UV-Vis spectra [88].…”

Section: Drug Delivery Of Functionalized Nanoferrites For Cancer Treatmentsmentioning

confidence: 99%

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Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Osorio¹,

Herrera²,

Londoño³

et al. 2021

Ferrites - Synthesis and Applications

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Cancer is the second cause of death worldwide, whose treatment often involves chemotherapy. In a conventional therapy, drug is transported (and usually absorbed) across biological membranes through diffusion and systemic transport. The pathway that medicine must travel before reaching the desired location, can bring adverse or unwanted effects, which are mainly the result of: low bioavailability, low solubility and toxicity. To avoiding risks, nanoparticles coated with the drug could be used as a therapeutic substance to selectively reach an area of interest to act without affecting non-target cells, organs, or tissues (drug delivery). Here, the goal is to enhance the concentration of the chemotherapeutic drug in the disease parts of the body. Among all nanostructured systems, ferrites attract worldwide attention in drug delivery applications. It is due to their versatile magnetic and physicochemical properties. Here, it is reviewed and analyzed recent advances in synthesis, morphology, size, magnetic properties, functionalization with a focus in drug delivery applications of nanoferrites.

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Camptothecin-Carrying Cobalt-Doped Copper Sulfide Nanoparticles

et al. 2023

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β-Cyclodextrin-folate functionalized poly(lactic-co-glycolide)–superparamagnetic ytterbium ferrite hybrid nanocarrier for targeted delivery of camptothecin

Cited by 23 publications

References 34 publications

Camptothecin-Carrying Cuco2s4 Nanoparticles: Sustained Drug Release And Anticancer Activity

Camptothecin-Carrying Cuco2s4 Nanoparticles: Sustained Drug Release And Anticancer Activity

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Camptothecin-Carrying Cobalt-Doped Copper Sulfide Nanoparticles

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