β-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs

Iannazzo, Daniela; Mazzaglia, Antonino; Scala, Angela; Pistone, Alessandro; Galvagno, S.; Lanza, M.; Riccucci, C.; Ingo, G. M.; Colao, Ivana; Sciortino, Maria Teresa; Valle, Francesco; Piperno, Anna; Grassi, Giovanni

doi:10.1016/j.colsurfb.2014.09.025

Cited by 30 publications

(17 citation statements)

References 38 publications

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“…This reaction was carried out using the well described Tour protocol [ 29 – 30 ]: the nanomaterials and 1 were dispersed in DMF, then isopentyl nitrite was added and the mixture kept at 80 °C for 24 h. The ox-MWCNTs derivative 6 was isolated through filtration over a 0.2 µm PTFE membranes followed by repeated washings with different solvents to remove excess reagents, while the GPs 7 was recovered after several cycles of centrifugation and dispersion.…”

Section: Resultsmentioning

confidence: 99%

Nanostructured carbon materials decorated with organophosphorus moieties: synthesis and application

Biagiotti¹,

Langé²,

Ligi³

et al. 2017

Beilstein J. Nanotechnol.

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A new synthetic approach for the production of carbon nanomaterials (CNM) decorated with organophosphorus moieties is presented. Three different triphenylphosphine oxide (TPPO) derivatives were used to decorate oxidized multiwalled carbon nanotubes (ox-MWCNTs) and graphene platelets (GPs). The TPPOs chosen bear functional groups able to react with the CNMs by Tour reaction (an amino group), nitrene cycloaddition (an azido group) or CuAAC reaction (one terminal C–C triple bond). All the adducts were characterized by FTIR, Raman spectroscopy, TEM, XPS, elemental analysis and ICP-AES. The cycloaddition of nitrene provided the higher loading on ox-MWCNTs and GPs as well, while the Tour approach gave best results with nanotubes (CNTs). Finally, we investigated the possibility to reduce the TPPO functionalized CNMs to the corresponding phosphine derivatives and applied one of the materials produced as heterogeneous organocatalyst in a Staudinger ligation reaction.

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Section: Resultsmentioning

confidence: 99%

Nanostructured carbon materials decorated with organophosphorus moieties: synthesis and application

Biagiotti¹,

Langé²,

Ligi³

et al. 2017

Beilstein J. Nanotechnol.

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“…Compared to covalent surface modification of CNTs, the noncovalent functionalization possesses the advantage of no disruption of the chemical structure and electronic property of the nanotubes . The common materials linked noncovalently to the surface of CNTs, especially multiwalled CNTs (MWCNTs), are chitosan , CD , micelle , and polymer . In recent years, some poly‐β‐CD wrapped MWCNTs prepared by noncovalent modification methods have been reported.…”

Section: Introductionmentioning

confidence: 99%

Trace amounts of poly‐β‐cyclodextrin wrapped carbon nanotubes for the microextraction of flavonoids in honey samples by capillary electrophoresis with light‐emitting diode induced fluorescence detection

Yang

et al. 2016

Electrophoresis

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A novel dispersive micro-SPE method with trace poly-β-CD wrapped multiwalled carbon nanotubes as sorbents was applied to extract flavonoids in honey samples. The analytes were then determined by CE with LED-induced fluorescence detection. The influencing parameters, such as the sorbent concentration, extraction time, and eluent type, were properly optimized. The established method had the advantages of simplicity, low consumption of sorbent amount (0.009 mg) and organic solvent (100 μL), and high sensitivity, meeting the principle of green chemistry. Under the optimum conditions, the sorbents allowed the extraction and preconcentration of the flavonoids with enrichment factors in the range from 78 to 166. The recovery study performed at two different fortification levels provided an average recovery >91%. LODs for all the compounds ranged from 0.07 to 17.99 ng/mL. These results demonstrated that the proposed method could be used as a convenient and efficient extraction technique for analysis of flavonoids in different honey matrices.

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“…Size measurements revealed two main groups of fibrils with different maximum average lengths, 160 ± 50 nm and 340 ± 150 nm respectively, and their height was (2.5 ± 0.3) nm ( Figure S1); the latter value may be influenced by the applied load. 44 At a concentration of 1.0 mg mL -1 , on the other hand, few birefringent microfibers were still present. The XRD patterns reported in Figure 1D showed that the squid pen, the chitin isolated using enzymatic digestion, and the β-CnFs dispersion, all conserved the β structure.…”

mentioning

confidence: 98%

“…However, during their growth the β-CnFs started aggregating laterally as well, forming loosely packed bundles. In nature chitin fibrils are frequently wrapped in a protein folder, as in insect cuticle, [44] [45] nacre organic matrix, 51 or in the squid pen. 9 Our observations indicate that these proteins play a crucial role in the perfectly registered chitin self-assembly.…”

mentioning

confidence: 99%

β-Chitin Nanofibril Self-Assembly in Aqueous Environments

et al. 2019

Self Cite

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Chitin is one of the most studied biopolymers but the understanding of how it assembles from molecules to micro-fibers is still limited. Organisms are able to assemble chitin with precise control over polymorphism, texture, and final morphology. The produced hierarchical structure leads to materials with outstanding mechanical properties. In this study the self-assembly in aqueous solutions of β-chitin nano-fibrils, as far as possible similar to their native state, is investigated. These nano-fibrils increase their tendency to self-assemble in fibers, up to millimetric length and ≈10 µm thickness, with the pH increasing from 3 to 8, forming loosely organized bundles as observed using cryo-TEM. The knowledge from this study contributes to the understanding of the self-assembly process that follows chitin once extruded from cells in living organisms. Moreover, it describes a model system which can be used to investigate how other biomolecules can affect the self-assembly of chitin nano-fibrils.

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β-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs

Cited by 30 publications

References 38 publications

Nanostructured carbon materials decorated with organophosphorus moieties: synthesis and application

Nanostructured carbon materials decorated with organophosphorus moieties: synthesis and application

Trace amounts of poly‐β‐cyclodextrin wrapped carbon nanotubes for the microextraction of flavonoids in honey samples by capillary electrophoresis with light‐emitting diode induced fluorescence detection

β-Chitin Nanofibril Self-Assembly in Aqueous Environments

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