β-Cyclodextrin Nanosponges as Multifunctional Ingredient in Water-Containing Semisolid Formulations for Skin Delivery

Conte, Claudia; Caldera, Fabrizio; Catanzano, Ovidio; d’Angelo, Ivana; Ungaro, Francesca; Miro, Agnese; Pellosi, Diogo Silva; Trotta, Francesco; Quaglia, Fabiana

doi:10.1002/jps.24203

Cited by 40 publications

(16 citation statements)

References 28 publications

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“…Conte et al, developed cyclodextrin nanosponges with pyromellitic dianhydride as cross linker and loaded them in semi-solid formulations for skin delivery. Skin permeation studies in diclofenac sodium loaded nanosponge gel and cream gels significantly retarded the drug permeation through skin while enhancing its concentration in viable epidermis and stratum corneum, confirming the localization of highly penetrating drugs in external layers of skin [11].…”

Section: Topical Drug Deliverymentioning

confidence: 64%

“…Nanosponge based drug delivery system is used to improve the performance of drugs administered orally, parenterally, pulmonary and topically [10]. Many active moieties with different pharmacological activities, structures and solubility have been encapsulated in NSs, including camptothecin, paclitaxel, doxorubicin, dexamethasone, 5-fluorouracil, itraconazole, nelfinavir mesylate, progesterone, tamoxifen and resveratrol [11]. Further, we acknowledge some excellent reviews that have been published earlier on nanosponges [8,[12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Kumar¹,

Dalal²,

Rao³

2020

Colloid Science in Pharmaceutical Nanotechnology

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Nanotechnology showed great promise and impact on administration of therapeutic agents owing to its advantages over contemporary delivery systems. Nanoscale carriers like nanosponges represent a novel category of hyper crosslinked polymer structures with nanosized cavities which can be filled with variety of active moieties (hydrophilic as well as hydrophobic). These nanocarriers can circulate around the body until they found the specific target site and adhere on the surface and release the active moiety in a predictable and controlled manner, resulting in more effective delivery of a given dosage. Nanosponge technology helps to reduce drug associated side effects, improve stability, increase elegance and improve the flexibility of formulations, administered orally, parenterally and topically. Among nanosponges, cyclodextrin-based nanosponges (CDNS) are smart versatile carriers studied widely for drug delivery applications. Statistically, it have presented that approximately 40% of active moieties marketed currently and about 90% of active moieties in their preliminary phase confront problems regarding to solubility. In the past decade, the number of studies describing CDNS has dramatically increased. In the present chapter, scientists working in arena of nanotechnology can get an idea of fabrication, characterization and therapeutic utilities of nanosponges.

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Section: Topical Drug Deliverymentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Kumar¹,

Dalal²,

Rao³

2020

Colloid Science in Pharmaceutical Nanotechnology

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“…Cyclodextrin-based nanosponges have been designed in the last years to increase the dissolution rate, the solubility and stability of drugs, or to prolong the release time, and also applied in semisolid formulations for skin delivery (Ansari et al 2011;Shende et al 2013;Conte et al 2014). Recently, experimental design has been used to formulate tablets using polymeric nanosponges for a combination therapy of three anti-inflammatory drugs (Moin et al 2020).…”

Section: Cyclodextrin Polymers In Drug Deliverymentioning

confidence: 99%

History of cyclodextrin-based polymers in food and pharmacy: a review

Petitjean

García-Zubiri²,

Isasi

2021

Environ Chem Lett

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“…PMDA-NS was first used as a multifunctional semisolid ingredient for drug delivery to the skin by Conte and the others in 2014. The effect of NS on the solubility and photostability of the photosensitizer benzoporphyrin-derivative monoacid ring A (BPDMA) and all-trans retinoic acid (ATRA), as well as the effect of diclofenac on skin permeation, were investigated [45].…”

Section: Dermal Transportmentioning

confidence: 99%

Biomedical Application of Cyclodextrin Polymers Cross-Linked via Dianhydrides of Carboxylic Acids

et al. 2020

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Cyclodextrin-based nanosponges (CD-NS) are a novel class of polymers cross-linked with a three-dimensional network and can be obtained from cyclodextrins (CD) and pyromellitic dianhydride. Their properties, such as their ability to form an inclusion complex with drugs, can be used in biomedical science, as nanosponges influence stability, toxicity, selectivity, and controlled release. Most pharmaceutical research use CD-NS for the delivery of drugs in cancer treatment. Application of molecular targeting techniques result in increased selectivity of CD-NS; for example, the addition of disulfide bridges to the polymer structure makes the nanosponge sensitive to the presence of glutathione, as it can reduce such disulfide bonds to thiol moieties. Other delivery applications include dermal transport of pain killers or photosensitizers and delivery of oxygen to heart cells. This gives rise to the opportunity to transition to medical scaffolds, but more, in modern times, to create an ultrasensitive biosensor, which employs the techniques of surface-modified nanoparticles and molecularly imprinted polymers (MIP). The following review focuses on the biomedical research of cyclodextrin polymers cross-linked via dianhydrides of carboxylic acids.

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β-Cyclodextrin Nanosponges as Multifunctional Ingredient in Water-Containing Semisolid Formulations for Skin Delivery

Cited by 40 publications

References 28 publications

Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

History of cyclodextrin-based polymers in food and pharmacy: a review

Biomedical Application of Cyclodextrin Polymers Cross-Linked via Dianhydrides of Carboxylic Acids

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