β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential therapy for vaginal candidiasis and pre-exposure prophylactic for HIV

Vartak, Richa; Patki, Manali; Menon, Suvidha; Jablonski, Joseph; Mediouni, Sonia; Fu, Yige; Valente, Susana T.; Billack, Blasé; Patel, Ketan

doi:10.1016/j.ijpharm.2020.119863

Cited by 29 publications

(16 citation statements)

References 61 publications

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“…Well plates were centrifuged and supernatant was withdrawn. Each supernatant with reagent was analyzed at 490 nm for the concentration of LDH released in the presence of each treatment using an Epoch 2 plate reader (BioTek Instruments, VT, USA) [ 21 ]. The interference of the liposomal formulation in the absorbance measurement was eliminated by subtracting it from the blank control (treatment without cells).…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, 10,000 molecular weight cutoff Slide-A-Lyzer dialysis cassettes (0.1–3 ml; Thermo Fisher Scientific) were hydrated in the prepared SLF medium for 10 min prior to use. As DPPC is an essential lung surfactant, modified SLF-3 medium (i.e., SLF-4) was prepared as previously described in the literature [ 21 ]. Briefly, concentrated, blank DPPC liposomes were added to the SLF-3 fluid to account for the lung surfactant.…”

Section: Methodsmentioning

confidence: 99%

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Aerosolized Nanoliposomal Carrier of Remdesivir: An Effective Alternative for COVID-19 Treatment In Vitro

Vartak

Patil

Saraswat

et al. 2021

Nanomedicine (Lond.)

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Aim: To formulate an aerosolized nanoliposomal carrier for remdesivir (AL-Rem) against coronavirus disease 2019. Methods: AL-Rem was prepared using modified hydration technique. Cytotoxicity in lung adenocarcinoma cells, stability and aerodynamic characteristics of developed liposomes were evaluated. Results: AL-Rem showed high encapsulation efficiency of 99.79%, with hydrodynamic diameter of 71.46 ± 1.35 nm and surface charge of -32 mV. AL-Rem demonstrated minimal cytotoxicity in A549 cells and retained monolayer integrity of Calu-3 cells. AL-Rem showed sustained release, with complete drug release obtained within 50 h in simulated lung fluid. Long-term stability indicated >90% drug recovery at 4°C. Desirable aerosol performance, with mass median aerodynamic diameter of 4.56 ± 0.55 and fine particle fraction of 74.40 ± 2.96%, confirmed successful nebulization of AL-Rem. Conclusion: AL-Rem represents an effective alternative for coronavirus disease 2019 treatment.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Aerosolized Nanoliposomal Carrier of Remdesivir: An Effective Alternative for COVID-19 Treatment In Vitro

Vartak

Patil

Saraswat

et al. 2021

Nanomedicine (Lond.)

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“…E β polySol film showed MIC of 20 × 10 –6 m against Candig mol –1 species and IC50 of 0.71 × 10 –6 m against HIV. [ 138 ]…”

Section: Cyd Polymers As Delivery Systems Of Therapeutic Agentsmentioning

confidence: 99%

Implementation of Water‐Soluble Cyclodextrin‐Based Polymers in Biomedical Applications: How Far Are We?

Agnes

Pancani

Fenyvesi

et al. 2022

Macromolecular Bioscience

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Cyclodextrin-based polymers can be prepared starting from the naturally occurring monomers following green and low-cost procedures. They can be selectively derivatized pre-or post-polymerization allowing to fine-tune functionalities of ad hoc customized polymers. Preparation nowadays has reached the 100 g scale thanks also to the interest of industries in these extremely versatile compounds. During the last 15 years, these macromolecules have been the object of intense investigations in view of possible biomedical applications as the ultimate goal and large amounts of scientific data are now available. Compared to their monomeric models, already used in the formulation of various therapeutic agents, they display superior behavior in terms of their solubility in water and solubilizing power toward drugs incompatible with biological fluids. Moreover, they allow the combination of more than one type of therapeutic agent in the polymeric system. In this review, a complete state of the art on the knowledge and potentialities of water-soluble cyclodextrin-based polymers as therapeutic agents as well as carrier systems for different types of therapeutics to implement combination therapy is provided. Finally, a perspective on their assets for innovation in disease treatment as well as their limits that still need to be addressed is given. Introduction Cyclodextrins at First SightCyclodextrins (CyDs) are water soluble, biocompatible macrocyclic oligosaccharides, made of 𝛼-d-glucopyranose units joined by 𝛼(1-4) linkages (Figure 1a). [1,2] These natural macrocycles

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“…They are usually soft, flexible, preferably colorless and odorless, and disperse or dissolve upon coming in contact with vaginal fluids to adhere and retain in the vaginal mucosa for prolonged durations [264]. Several polymers have been investigated over the years for formulating vaginal films, the most commonly used ones being polyvinyl alcohol [265][266][267][268][269][270][271] and cellulose derivatives [272][273][274] or a combination of both [194,249,253,[275][276][277][278]. Other polymers have also been explored with or without the previously mentioned common options [223,263,279,280].…”

Section: Vaginal Filmsmentioning

confidence: 99%

Recent Advances in Polymer-Based Vaginal Drug Delivery Systems

et al. 2021

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The vagina has been considered a potential drug administration route for centuries. Most of the currently marketed and investigated vaginal formulations are composed with the use of natural or synthetic polymers having different functions in the product. The vaginal route is usually investigated as an administration site for topically acting active ingredients; however, the anatomical and physiological features of the vagina make it suitable also for drug systemic absorption. In this review, the most important natural and synthetic polymers used in vaginal products are summarized and described, with special attention paid to the properties important in terms of vaginal application. Moreover, the current knowledge on the commonly applied and innovative dosage forms designed for vaginal administration was presented. The aim of this work was to highlight the most recent research directions and indicate challenges related to vaginal drug administrations. As revealed in the literature overview, intravaginal products still gain enormous scientific attention, and novel polymers and formulations are still explored. However, there are research areas that require more extensive studies in order to provide the safety of novel vaginal products.

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β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential therapy for vaginal candidiasis and pre-exposure prophylactic for HIV

Cited by 29 publications

References 61 publications

Aerosolized Nanoliposomal Carrier of Remdesivir: An Effective Alternative for COVID-19 Treatment In Vitro

Aerosolized Nanoliposomal Carrier of Remdesivir: An Effective Alternative for COVID-19 Treatment In Vitro

Implementation of Water‐Soluble Cyclodextrin‐Based Polymers in Biomedical Applications: How Far Are We?

Recent Advances in Polymer-Based Vaginal Drug Delivery Systems

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