β-endorphin-like immunoreactivity levels in the hypothalamus, the periaqueductal grey and the pituitary of the DBA mouse: Determination by ELISA and relationship to nociception

Külling, P.; Siegfried, Bert; Frischknecht, Hans-Rudolf; Messiha, F.S.; Pasi, Aurelio

doi:10.1016/0031-9384(89)90315-6

Cited by 16 publications

(7 citation statements)

References 14 publications

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“…(CBA• F 1 hybrids were used, which show a greater variation of the examined parameters than pure-strain animals. Since stress-induced analgesia is known to develop within the first 3 h of nociceptive exposure [12], the mice were immunized with sheep red cells 3 h after the first measurement of TPS. The count of antibody-producing cells (APC) in the spleen was assessed on day 5 of the immune response.…”

Section: Resultsmentioning

confidence: 99%

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Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

et al. 1995

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A hypothesis about a correlation between threshold pain sensitivity and antibody production is proposed and experimentally validated. Immunodeficient mouse strains are characterized by a higher threshold sensitivity to pain than animals with a normal immune response. A highly reliable negative correlation between threshold sensitivity to pain assessed by the hot plate test and the number of antibody-producing cells in the spleen after immunization with sheep red cells is observed in 77% of (CBAxC57B1/ 6) F 1 mice examined. The negative correlation is observed both in spontaneous variations of threshold pain sensitivity and during an elevation of this threshold under the effect of preceding nociceptive stimulation.

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Section: Resultsmentioning

confidence: 99%

“…IL-2 can induce the maturation of undifferentiated cell forms into cytotoxic row: precursors which can be transformed into cytotoxic cells in the presence of IL-2, and nontransformed cells [12].…”

Section: Abstract: Natural Milers; Interleukin-3; Proliferationmentioning

confidence: 99%

Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

et al. 1995

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“…Furthermore, SIA induced by social conflict was associated with a decrease in beta-endorphin-like immunoreactivity in the PAG (Kulling et al, 1988). These authors also report that individual differences in baseline betaendorphin-like immunoreactivity in the PAG correlate with the expression of high or low SIA (Kulling et al, 1989). In a rat model of FCA, the acquisition of conditioned fear and the expression of FCA were both impaired with a unilateral injection of morphine into the amygdala (Good and Westbrook, 1995).…”

Section: Mediation and Modulation Of Sia By The Opioid Systemmentioning

confidence: 78%

Stress-Induced Analgesia

Tricklebank¹,

Curzon²

2013

Encyclopedia of Pain

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Abbreviations: SIA, stress-induced analgesia; FCA, fear-conditioned analgesia; GABA, Ȗ-aminobutyric acid; HA, high analgesia; LA, low analgesia; fMRI, functional magnetic resonance imaging; DNIC, diffuse noxious inhibitory control; PAG, periaqueductal grey; RVM, rostroventral medulla; 5-HT, 5-hydroxytryptamine; CB 1 , cannabinoid type 1; CB 2 , cannabinoid type 2; NMDA, N-methyl-D-aspartic acid; AMPA, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; mGluR, metabotropic glutamate receptor; NK1, neurokinin 1; SP, substance P; 2-AG, 2-arachidonoylglycerol; FAAH, fatty acid amide hydrolase; MGL, monoacylglycerol lipase; HPA, hypothalamo-pituitary-adrenal; ACTH, adrenocorticotropic hormone 3 ABSTRACT For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stressinduced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia sensitivity can vary a great deal depending on age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway.Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the HQGRJHQRXV RSLRLG PRQRDPLQH FDQQDELQRLG Ȗ-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and has been a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders.4

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“…50 9 Plenum Publ/shing Corporation mouse spleens using a modified method of Cunningham [4]. Peptides were injected intraperitoneally in concentrations of 10-6-10 13 g/mouse one day before immunization with antigen simultaneously, or on day 1, 2, 3, or 4 after immunization in 0.2 ml volume.…”

Section: Methodsmentioning

confidence: 99%

“…Here, an analysis based on absolute individual differences of AT is not sufficient because of individual basal level variability. The same numerical value of hot plate test parameters may correspond in one animal to a state of stress-induced analgesia (as a result of social tension, for example [9,12]), and in another to a spontaneous, stress-free state. Such circumstances evidently account for the differences in the modes of action of bone marrow hexapeptides on algesthesia.…”

Section: 40mentioning

confidence: 99%

Influence of bone marrow hexapeptides (myelopeptides) on antibody production and algesthesia in mice and the dependence of these effects on naloxone

et al. 1995

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It is shown that synthetic analogs of two bone marrow hexapeptides (myelopeptides 1 and 2), which are identical in structure to the N-terminal peptide fragments of hemoglobin ~-and 15-chains, are characterized by naloxone-independent antibody-stimulating activity. The antibody-stimulating effect of the myelopeptides becomes naloxonedependent and stronger against the background of immunosuppression provoked by the hot plate test carried out before immunization. Intraperitoneal administration of both myelopeptides in doses of 10-13-10 -g g/mouse causes a naloxone-dependent modulatory effect on mouse algesthesia threshold with a predominant analgetic effect. Key words: antibody production; algesthesia threshold; naloxone; hexapeptidesIt is known that bone marrow cells of various animal species and of human origin produce humoral factors (myelopeptides -MP) which influence immune response development and algesthesia [3,10]. There are reports that MP can produce dose-dependent opposite effects on algesthesia correlating with the immune response [1,13]. The presence of opioid peptides in MP and the naloxone-dependence of its antibody-stimulating and analgetic effects point to the participation of bone marrow opioids along with other MP in the realization of these effects [2,10]. However, the identification of individual MP molecules responsible for immuno-and neurotropic properties requires their isolation from the mixture.At present two such compounds, MP1 and MP2, are structurally characterized. They are The objective of the present investigation was to study the influence of hexapeptides on antibody production and algesthesia in mice and the dependence of these effects on naloxone. MATERIALS AND METHODSExperiments were carried out on (CBAxC57B1/6) F 1 hybrid mice and on CBA strain mice of 18-20 g weight. Mice were immunized with a single intraperitoneal injection of 0.5 ml of 5% or 0.05% sheep red blood cell suspension 20, 60, or 180 min after algesthesia threshold (AT) determination.The enhancing effect of MP1 and MP2 on antibody production was-assessed by estimation of the number of antibody-producing cells (APC) in 0007-4888/95/0004-0400512.50 9Plenum Publ/shing Corporation

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β-endorphin-like immunoreactivity levels in the hypothalamus, the periaqueductal grey and the pituitary of the DBA mouse: Determination by ELISA and relationship to nociception

Cited by 16 publications

References 14 publications

Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

Stress-Induced Analgesia

Influence of bone marrow hexapeptides (myelopeptides) on antibody production and algesthesia in mice and the dependence of these effects on naloxone

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