β-Glucans are involved in immune-modulation of THP-1 macrophages

Chanput, Wasaporn; Reitsma, Marit; Kleinjans, Lennart; Mes, Jurriaan J.; Savelkoul, H.F.J.; Wichers, H.J.

doi:10.1002/mnfr.1734

Cited by 9 publications

(9 citation statements)

References 41 publications

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“…In the previous reports, PLM showed wide spectrum of bioactivities, such as antioxidant, anti-inflammatory, cytotoxic, antiviral, and antidiabetic effects [26][27][28]. Especially, β-glucan isolated from mushroom is a natural polysaccharide and possess various biological effects such as immune-modulating properties, antitumor, anti-infection, and lowering blood cholesterol [29,30].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Phellinus linteus Mycelium on the Development of Osteoarthritis after Monosodium Iodoacetate Injection

Shin

Lee

Kim

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study was to identify the protective effects of Phellinus linteus mycelium (PLM) and its possible mechanisms in a model of monosodium iodoacetate- (MIA-) induced osteoarthritis (OA). Methods. Intra-articular injection of MIA was injected to 50 μL with 80 mg/mL using a 0.3 mL insulin syringe into the right knee joint. Changes in hindpaw weight-bearing distribution between the right (osteoarthritic) and left (contralateral control) legs were used as an index of joint discomfort. PLM (50, 100, and 200 mg/kg body weight) was orally administered once daily for 14 days from day 7 after MIA treatment. And then, various factors associated with inflammatory response and cartilage degeneration in cartilage tissues detected by western blotting. Results. PLM treatment showed a concentration-dependent elevation in change in hindpaw weight-bearing distribution (HWBD). PLM200 demonstrated the capacity to significantly increase HWBD, indicating that the change in weight-bearing distribution means the reduction of spontaneous pain. Our results indicate that PLM suppressed the inflammatory factors via NF-κB signaling pathway induced by p38 phosporlyation. Moreover, PLM200 exhibited a significant reduction of ROS produced by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. PLM100 and PLM200 inhibited the levels of matrix metalloproteinase (MMP)-1, one of proteinase that degrades extracellular matrix (ECM). Conclusions. Taken together, our results indicated that PLM has a strong chondroprotective effect through the suppression both ROS production and inflammation.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Phellinus linteus Mycelium on the Development of Osteoarthritis after Monosodium Iodoacetate Injection

Shin

Lee

Kim

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…We assessed the effect of complete homogenates of eight mushroom species and the polysaccharide fraction of two mushrooms, curdlan and zymosan on THP‐1 monocytes and macrophages. For A. subrufescens and L. edodes it was shown before that cytokine secretion was induced in THP‐1 macrophages . We revealed that mushroom compounds that were able to induce cytokine secretion always elicited a better response on THP‐1 macrophages than THP‐1 monocytes (Fig.…”

Section: Discussionmentioning

confidence: 57%

“…Purified citrus pectin or barley glucan reduced LPS‐induced expression of all inflammation‐related genes except TNF‐ α (only in monocytes) and COX‐2 (in monocytes and macrophages). Food compounds can also up‐regulate expression of genes related to immune function in THP‐1 cells, as was demonstrated using extracts from the mushrooms Ganoderma lucidum , L. edodes , Agaricus bisporus and A. subrufescens . We assessed the effect of complete homogenates of eight mushroom species and the polysaccharide fraction of two mushrooms, curdlan and zymosan on THP‐1 monocytes and macrophages.…”

Section: Discussionmentioning

confidence: 99%

Assessing the immunomodulatory potential of high‐molecular‐weight extracts from mushrooms; an assay based on THP‐1 macrophages

et al. 2014

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“…Velde et al studied the immunomodulatory potential of the Agaricus subrufescens and Coprinus comatus species of mushroom using the THP-1 cells [ 116 ]. Various other researchers also evaluated the upregulation of genes using the extracts of Ganoderma lucidum , L. edodes , Agaricus bisporus , and A. subrufescens [ 117 , 118 , 119 , 120 ]. Velde et al isolated the polysaccharide fraction of two mushrooms as curdlan and zymosan.…”

Section: Pharmacological Actions Of Mushroommentioning

confidence: 99%

Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product

Chopra

Mishra

Baig

et al. 2021

JoF

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Mushrooms have remained an eternal part of traditional cuisines due to their beneficial health potential and have long been recognized as a folk medicine for their broad spectrum of nutraceuticals, as well as therapeutic and prophylactic uses. Nowadays, they have been extensively investigated to explain the chemical nature and mechanisms of action of their biomedicine and nutraceuticals capacity. Mushrooms belong to the astounding dominion of Fungi and are known as a macrofungus. Significant health benefits of mushrooms, including antiviral, antibacterial, anti-parasitic, antifungal, wound healing, anticancer, immunomodulating, antioxidant, radical scavenging, detoxification, hepatoprotective cardiovascular, anti-hypercholesterolemia, and anti-diabetic effects, etc., have been reported around the globe and have attracted significant interests of its further exploration in commercial sectors. They can function as functional foods, help in the treatment and therapeutic interventions of sub-optimal health states, and prevent some consequences of life-threatening diseases. Mushrooms mainly contained low and high molecular weight polysaccharides, fatty acids, lectins, and glucans responsible for their therapeutic action. Due to the large varieties of mushrooms present, it becomes challenging to identify chemical components present in them and their beneficial action. This article highlights such therapeutic activities with their active ingredients for mushrooms.

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β-Glucans are involved in immune-modulation of THP-1 macrophages

Cited by 9 publications

References 41 publications

Protective Effects of Phellinus linteus Mycelium on the Development of Osteoarthritis after Monosodium Iodoacetate Injection

Protective Effects of Phellinus linteus Mycelium on the Development of Osteoarthritis after Monosodium Iodoacetate Injection

Assessing the immunomodulatory potential of high‐molecular‐weight extracts from mushrooms; an assay based on THP‐1 macrophages

Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product

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