β-TCP versus Autologous Bone for Repair of Alveolar Clefts in a Goat Model

Ruiter, Ad de; Meijer, G.J.; Dormaar, Titiaan; Janssen, Nard G.; Bilt, Andries van der; Slootweg, Piet J.; Bruijn, Joost D. de; Rijn, Linda van; Koole, R.

doi:10.1597/09-219

Cited by 29 publications

(27 citation statements)

References 36 publications

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“…The alveolar region has its own particular characteristics, predominantly consisting of cancellous bone that is thinner and has higher porosity than the calvarial bone. 34 Thus, it is an ideal site to test less brittle materials: first, because there is no need to protect the underlying neurovascular bundle, and second, because a softer material presents a higher porosity that can ultimately simulate the cancellous bone of this region and also facilitate teeth eruption and mobilization during orthodontia. Therefore, the mechanical strength in this region is of less importance when compared to the calvarial region.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the mechanical strength in this region is of less importance when compared to the calvarial region. De Ruiter et al 34 repaired alveolar defects in a goat model using β-TCP. De Ruiter et al 34 emphasized the importance of orthodontic tooth movement while repairing an alveolar defect with these biomaterials.…”

Section: Discussionmentioning

confidence: 99%

“…De Ruiter et al 34 repaired alveolar defects in a goat model using β-TCP. De Ruiter et al 34 emphasized the importance of orthodontic tooth movement while repairing an alveolar defect with these biomaterials. We believe that α-TCP may behave even better than β-TCP for this particular situation, owing to its higher porosity and solubility.…”

Section: Discussionmentioning

confidence: 99%

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Is bone transplantation the gold standard for repair of alveolar bone defects?

et al. 2014

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New strategies to fulfill craniofacial bone defects have gained attention in recent years due to the morbidity of autologous bone graft harvesting. We aimed to evaluate the in vivo efficacy of bone tissue engineering strategy using mesenchymal stem cells associated with two matrices (bovine bone mineral and α-tricalcium phosphate), compared to an autologous bone transfer. A total of 28 adult, male, non-immunosuppressed Wistar rats underwent a critical-sized osseous defect of 5 mm diameter in the alveolar region. Animals were divided into five groups. Group 1 (n = 7) defects were repaired with autogenous bone grafts; Group 2 (n = 5) defects were repaired with bovine bone mineral free of cells; Group 3 (n = 5) defects were repaired with bovine bone mineral loaded with mesenchymal stem cells; Group 4 (n = 5) defects were repaired with α-tricalcium phosphate free of cells; and Group 5 (n = 6) defects were repaired with α-tricalcium phosphate loaded with mesenchymal stem cells. Groups 2–5 were compared to Group 1, the reference group. Healing response was evaluated by histomorphometry and computerized tomography. Histomorphometrically, Group 1 showed 60.27% ± 16.13% of bone in the defect. Groups 2 and 3 showed 23.02% ± 8.6% (p = 0.01) and 38.35% ± 19.59% (p = 0.06) of bone in the defect, respectively. Groups 4 and 5 showed 51.48% ± 11.7% (p = 0.30) and 61.80% ± 2.14% (p = 0.88) of bone in the defect, respectively. Animals whose bone defects were repaired with α-tricalcium phosphate and mesenchymal stem cells presented the highest bone volume filling the defects; both were not statistically different from autogenous bone.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Is bone transplantation the gold standard for repair of alveolar bone defects?

et al. 2014

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“…It was then established that TCP graft made better bone regeneration than the autograft did. 3 According to an experiment on mice conducted by Ru N et al, TCP graft had higher osteoconductivity and better biomechanic property than cancellous bone graft or without graft. 4 Another research on humans has shown that there was remarkable bone volume addition (73% ± 6% of its initial volume) during 6 months after bone grafting with TCP.…”

Section: Discussionmentioning

confidence: 99%

Cancellous Bone Versus Tricalcium Phospate (TCP) For Bone Grafting: A Literature Review And Case Report Of Alveolar Bone Grafting In Cipto Mangunkusumo Hospital

Maulana¹,

Primadian²,

Pancawati³

et al. 2018

J Plast Rekons

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Background: In the last decade, there are various methods of bone grafting in plastic surgery. Cancellous bone is more often used as bone graft than cortical bone due to its high osteoconductivity and osteogenic capability. The synthetic materials for bone graft such as tricalcium phospate (TCP) and hydroxy-apatite can be use as new alternative for bone grafting surgery. Methods: The PubMed® databases were searched using the terms: ‘bone graft OR bone grafting’ AND ‘cancellous bone OR iliac crest OR tibia’ AND ‘tricalcium phospate OR tricalciumphospate OR tri calcium phospate’, restricted to English language, and to a publication period from January 2010 to January 2017. The inclusion criteria were any kind of research paper that compared the utility of TCP synthetic graft and autograft as a bone graft. Results: Out of 139 selected studies, only 8 met the inclusion criteria. In 6 publications TCP graft has similar outcome and in 1 publication have a better result in reducing post operative complication. Conclusion: TCP graft can be used as substitution for autograft in particular clinical conditions and surgical methods.

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“…These results suggest that β -TCP alone implantation is not sufficient to fill the defect with regenerated bone in the craniofacial region. Some experimental studies have confirmed the osteoconductive properties of β -TCP, which were comparable to autologous bone grafts [15, 17, 70]. However, other groups have emphasized versatility by combining β -TCP with autologous bone fragments [16, 77–79], growth factors [45, 46, 80–84], simvastatin [71], or stem cells [18, 85, 86] in both experimental and clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model

Minagawa

Tabata

Oyama

et al. 2014

International Journal of Biomaterials

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Autologous bone grafts remain the gold standard for the treatment of congenital craniofacial disorders; however, there are potential problems including donor site morbidity and limitations to the amount of bone that can be harvested. Recent studies suggest that granulocyte colony-stimulating factor (G-CSF) promotes fracture healing or osteogenesis. The purpose of the present study was to investigate whether topically applied G-CSF can stimulate the osteoconductive properties of beta-tricalcium phosphate (β-TCP) in a rat calvarial defect model. A total of 27 calvarial defects 5 mm in diameter were randomly divided into nine groups, which were treated with various combinations of a β-TCP disc and G-CSF in solution form or controlled release system using gelatin hydrogel. Histologic and histomorphometric analyses were performed at eight weeks postoperatively. The controlled release of low-dose (1 μg and 5 μg) G-CSF significantly enhanced new bone formation when combined with a β-TCP disc. Moreover, administration of 5 μg G-CSF using a controlled release system significantly promoted the biodegradable properties of β-TCP. In conclusion, the controlled release of 5 μg G-CSF significantly enhanced the osteoconductive and biodegradable properties of β-TCP. The combination of G-CSF slow-release and β-TCP is a novel and promising approach for treating pediatric craniofacial bone defects.

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β-TCP versus Autologous Bone for Repair of Alveolar Clefts in a Goat Model

Abstract: The synthetic bone substitute β-TCP was shown to result in bone healing similar to that of iliac crest bone. The surgical, orthodontic, and histologic results now warrant the testing of β-TCP in the human cleft situation.

Cited by 29 publications

References 36 publications

Is bone transplantation the gold standard for repair of alveolar bone defects?

Is bone transplantation the gold standard for repair of alveolar bone defects?

Cancellous Bone Versus Tricalcium Phospate (TCP) For Bone Grafting: A Literature Review And Case Report Of Alveolar Bone Grafting In Cipto Mangunkusumo Hospital

Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model

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