β-Thymosins, small acidic peptides with multiple functions

Huff, Thomas; Müller, Christian S. G.; Otto, Angela M.; Netzker, Roland; Hannappel, Ewald

doi:10.1016/s1357-2725(00)00087-x

Cited by 355 publications

(330 citation statements)

References 124 publications

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“…Analysis of the deduced amino acids of carp Tβ-l gene revealed the existence of conserved actin binding LKKTET motif and two helix motifs. The highest similarity of amino acid sequences was found in those motifs of all known Tβs indicating that carp Tβ-l may play an important role in maintaining cellular functions, such as cell morphology, proliferation and locomotion (Huff et al, 2001).…”

Section: Discussionmentioning

confidence: 98%

“…Beta thymosins (Tβs) are a family of highly conserved polar 5-kDa polypeptides consisting of 40-44 amino acid residues. More than 15 kinds of Tβs have been reported (Huff et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…(Low et al, 1981). Later studies showed that Tβs' mRNA and protein levels were changed rapidly during differentiation or by different stimuli (Hall, 1991;Huff et al, 2001). Meanwhile, the archetypical Tβ, Tβ4 was found to play a fundamental role in the host defense mechanism (Gondo et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)

Xiao

Shen

Hong

et al. 2015

Developmental & Comparative Immunology

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Section: Discussionmentioning

confidence: 98%

“…Beta thymosins (Tβs) are a family of highly conserved polar 5-kDa polypeptides consisting of 40-44 amino acid residues. More than 15 kinds of Tβs have been reported (Huff et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)

Xiao

Shen

Hong

et al. 2015

Developmental & Comparative Immunology

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“…23,48 Measurements of the concentration of profilin in cells range from 5 lM in chick brain 12 to 55 lM in platelets. 17 However, not all profilin is necessarily available for binding to actin, as profilin has over 50 identified binding partners, 58 and in particular, it has been demonstrated that binding to phosphoinositides dissociates profiling-actin complexes.…”

Section: Parameter Choicesmentioning

confidence: 99%

“…Buffering of the monomeric actin pool by thymosin b4 allows cells to maintain large pools of unpolymerized actin 23 even in the presence of a low concentration of free barbed ends. We see this buffering in our model (compare Figs.…”

Section: Thymosin B4 Profilin and Cofilinmentioning

confidence: 99%

Relationships between Actin Regulatory Mechanisms and Measurable State Variables

Bindschadler

McGrath

2007

Ann Biomed Eng

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Abstract-In this report we extend our recent mathematical formulation of the actin cycle model [Bindschadler et al. Biophys. J. 86 (2004) 2720] to predict the influence of key regulatory mechanisms on network-scale state variables estimable in live cell experiments. Specifically, we examine the influence of regulation by cofilin, profilin, capping protein and proteins that adjust filament number through nucleation and/or filament severing, on the higher order variables of average filament length, polymer fraction, and filament turnover rate. Importantly, we find that severing/ nucleation, the acceleration of ADP-subunit disassembly by cofilin, and the catalytic and shuttle functions of profilin have Ôsignature' effects on the higher order state variables. In this way, measurement of the state variables in live cells can allow inference of regulatory mechanism(s) underlying changes in cell state. Our results compare favorably to published data for endothelial cells undergoing a transition from non-motile confluent cells to highly motile subconfluent cells. The extension of our model to higher order state variables allows us to investigate other important issues such as the distinction between basic and higher order measures of filament dynamics, the influence of thymosin b4 on network state variables, the interplay between thymosin b4 and profilin, and the synergystic effects of cofilin and profilin.

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Enrichment of poly(butyl methacrylate) and its graft copolymer of polybutadiene on the surface of polypropylene blend

Chen

Shi

Zhu

et al. 2007

J of Applied Polymer Sci

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ABSTRACT:The enrichment and diffusion of poly (butyl methacrylate) (PBMA) and its graft copolymer of polybutadiene on the surface of polypropylene (PP) blends were investigated using attenuated total reflection infrared spectroscopy (ATR-FTIR), contact angle measurements (CDA), and scanning electron microscopy (SEM). It has been found that the selective aggregation of the PBMA and its copolymers on the surface of blends is mainly affected by the content, molecular weight, and the segregated domains. Lower content and higher surface energy die are in favor of the enrichment of additives on the surface of PP. PBMA with higher molecular weight has lower diffusivity and bigger phase domains, which results in its lower enrichment on the surface of PP blend film.

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β-Thymosins, small acidic peptides with multiple functions

Cited by 355 publications

References 124 publications

Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)

Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)

Relationships between Actin Regulatory Mechanisms and Measurable State Variables

Enrichment of poly(butyl methacrylate) and its graft copolymer of polybutadiene on the surface of polypropylene blend

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