β-Trace Protein as a Marker for Cerebrospinal Fluid Rhinorrhea

Arrer, Erich; Meço, Cem; Oberascher, G; Piotrowski, W.; Albegger, Klaus; Patsch, Wolfgang

doi:10.1093/clinchem/48.6.939

Cited by 85 publications

(53 citation statements)

References 11 publications

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“…The sensitivity and specificity of beta trace protein testing reported from these studies ranges from 91% to 100% and 86% to 100%, rivaling beta‐2 transferrin in its accuracy. In the McCudden et al .…”

Section: Resultsmentioning

confidence: 90%

“…Various testing methods were described in these studies, including isoelectric focusing, immunofixation, and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE) with immunoblotting. Regardless of the testing method used, the sensitivity ranged from 87% to 100% and the specificity from 71% to 100% …”

Section: Resultsmentioning

confidence: 99%

“…The primary objective of 4 of the identified studies was reporting the accuracy of a specific beta‐2 transferrin testing method in comparison to established methods rather than highlighting the role of beta‐2 transferrin in the diagnostic algorithm for CSF rhinorrhea . However, the CSF samples used for these studies are from the same skull‐base CSF leak patient population, so they retain their validity.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis of cerebrospinal fluid rhinorrhea: an evidence‐based review with recommendations

Oakley

Alt

Schlosser

et al. 2015

Int Forum Allergy Rhinol

147

149

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis of cerebrospinal fluid rhinorrhea: an evidence‐based review with recommendations

Oakley

Alt

Schlosser

et al. 2015

Int Forum Allergy Rhinol

147

149

View full text Add to dashboard Cite

show abstract

“…Upon initial presentation with suspected CSF rhinorrhea, the first step in evaluation beyond physical exam and confirmed or provoked rhinorrhea is confirmation of a CSF leak. Laboratory testing for beta‐2 transferrin or beta trace protein is the initial preferred method of detection . Following laboratory confirmation, an attempt at localization of the skull‐base defect is warranted prior to operative intervention.…”

Section: Primary Csf Rhinorrheamentioning

confidence: 99%

ICAR: endoscopic skull‐base surgery

Wang

Zanation

Gardner

et al. 2019

Int Forum Allergy Rhinol

160

279

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Background Endoscopic skull‐base surgery (ESBS) is employed in the management of diverse skull‐base pathologies. Paralleling the increased utilization of ESBS, the literature in this field has expanded rapidly. However, the rarity of these diseases, the inherent challenges of surgical studies, and the continued learning curve in ESBS have resulted in significant variability in the quality of the literature. To consolidate and critically appraise the available literature, experts in skull‐base surgery have produced the International Consensus Statement on Endoscopic Skull‐Base Surgery (ICAR:ESBS). Methods Using previously described methodology, topics spanning the breadth of ESBS were identified and assigned a literature review, evidence‐based review or evidence‐based review with recommendations format. Subsequently, each topic was written and then reviewed by skull‐base surgeons in both neurosurgery and otolaryngology. Following this iterative review process, the ICAR:ESBS document was synthesized and reviewed by all authors for consensus. Results The ICAR:ESBS document addresses the role of ESBS in primary cerebrospinal fluid (CSF) rhinorrhea, intradural tumors, benign skull‐base and orbital pathology, sinonasal malignancies, and clival lesions. Additionally, specific challenges in ESBS including endoscopic reconstruction and complication management were evaluated. Conclusion A critical review of the literature in ESBS demonstrates at least the equivalency of ESBS with alternative approaches in pathologies such as CSF rhinorrhea and pituitary adenoma as well as improved reconstructive techniques in reducing CSF leaks. Evidence‐based recommendations are limited in other pathologies and these significant knowledge gaps call upon the skull‐base community to embrace these opportunities and collaboratively address these shortcomings.

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“…The bTP, synthesized in the leptomeninges (4) and the pachymeninx (5), is involved in prostaglandin metabolism (6) and acts as a carrier protein for retinoids (7). As the bTP is only synthesized in the CNS and in the male genital system, it is found in serum only in minute quantities and is therefore used as an indicator of CSF leakage (8). In this study, it was also used to control for possible dilution effects in the CSF.…”

Section: Introductionmentioning

confidence: 99%