β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models

Korovina, Irina; Elser, Marc; Borodins, Olegs; Seifert, Michael; Willers, Henning; Cordes, Nils

doi:10.1016/j.biopha.2024.116217

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.116217

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β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models

Irina Korovina,

Marc Elser,

Olegs Borodins

et al.

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2024

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Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC

Liu,

Han,

Wang

et al. 2024

Environmental Toxicology

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BackgroundHead and neck squamous cell carcinoma (HNSCC) presents a significant clinical challenge, particularly due to its high propensity for locoregional recurrence. Current research underscores the need to unravel the complex interactions within the tumor microenvironment. This study addresses the critical gap in understanding how FOS modulates the immune landscape in HNSCC, with a focus on its influence on fibroblast and myeloid cell dynamics.MethodsEmploying a comprehensive approach, we analyzed tissue samples from HNSCC patients and adjacent non‐cancerous tissues using bulk RNA sequencing complemented by in‐depth bioinformatics analyses, including gene ontology (GO), Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis, and immune infiltration assessment. A pivotal aspect of our research involved dissecting single‐cell RNA‐seq data from GSE234933 to elucidate the cell‐type‐specific expression of FOS.ResultsWe found that FOS expression varies significantly in different cell populations in the HNSCC tumor microenvironment, especially in fibroblasts and myeloid cells. This expression difference may reflect the different roles of these cells in tumor progression and their impact on the tumor microenvironment.ConclusionOur results uncover a significant correlation between FOS expression and key immune and hypoxia‐related pathways, suggesting its integral role in the tumor microenvironment. These findings not only enhance our understanding of HNSCC pathogenesis but also highlight FOS as a potential therapeutic target. This study marks a significant step towards addressing the urgent need for targeted interventions in HNSCC, particularly in the context of locoregional recurrence.

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Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC

Liu,

Han,

Wang

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

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β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models

Cited by 1 publication

References 38 publications

Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC

Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC

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