β1 Integrins in Epithelial Tissues: A Unique Distribution in the Lens

Menko, A Sue; Philip, Nisha

doi:10.1006/excr.1995.1186

Cited by 73 publications

(50 citation statements)

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“…This contrasts with the expression pattern seen in other epithelial tissues, where tight junctions at apical cell-cell boundaries restrict integrin expression to the basolateral membrane (Menko and Philp, 1995). This unusual feature of lens fiber cells may enable the anterior tips of elongating fiber cells to form attachments and migrate along the epithelial cells at the epithelial-fiber interface.…”

Section: A D B E C Fcontrasting

confidence: 62%

“…The localization of integrins in the lens is somewhat unusual, since β1 integrin has been detected on the apical membrane surface along the epithelial-fiber interface, as well as on the basolateral membranes (Menko and Philp, 1995). This contrasts with the expression pattern seen in other epithelial tissues, where tight junctions at apical cell-cell boundaries restrict integrin expression to the basolateral membrane (Menko and Philp, 1995).…”

Section: A D B E C Fmentioning

confidence: 90%

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Regulation of cell adhesion and migration in lens development

Zelenka¹

2004

Int. J. Dev. Biol.

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Cell movements during lens development and differentiation involve dynamic regulation of cell-matrix and cell-cell adhesion. How these processes are regulated depends on the particular array of matrix components and adhesion proteins that are expressed, as well as the signaling pathways that affect them. This review examines what is known about adhesion proteins and their regulation in the lens in light of recent findings about the mechanism of cell migration. The characteristic shape and organization of the lens depends on highly regulated cell movements during development and differentiation. Epithelial cells at the equator migrate posteriorly, bringing them into contact with factors in the vitreous humor and initiating differentiation. Elongation of the differentiating fiber cells is coupled with directed migration, posteriorly along the capsule and anteriorly along the fiber cell-epithelial interface, to generate a symmetrically organized fiber cell mass with aligned suture planes. To make these movements, cells systematically create and dissolve cell-cell and cell-matrix adhesions, form connections between these adhesions and the cytoskeleton, and generate contractile force. Since errors in cell migration may lead to aberrant lens shape or misplacement of the lens sutures, precise regulation of each step is essential for the optical quality of the lens. Recent advances in cellular developmental biology have begun to shed light on the molecular mechanisms underlying cell movements and the changes in adhesion that make them possible. This review will summarize those findings and relate them to relevant studies of the lens to provide an outline of the cellular events that lead to lens morphogenesis.

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Section: A D B E C Fcontrasting

confidence: 62%

Section: A D B E C Fmentioning

confidence: 90%

Regulation of cell adhesion and migration in lens development

Zelenka¹

2004

Int. J. Dev. Biol.

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“…ABCG2, often referred as a stem cells-and retinal progenitor cells marker, was expressed at a low level on the fvERM outgrowing cells (<1%), while it was much higher on the primary hRPE cells (17.63+15.09%) 106 . The immune status of the cells is also very important -no HLA-G expression of this immunosuppressive marker could be detected on both cell types, while HLA-DR expression was very low on these cells , but we detected more positivity for integrin α1 and integrin α2 in the primary hRPE cell cultures compared to the studies published to date 123 . The integrin pattern of our cells differed in their CD18/integrin β2 and CD51/integrin αV expression.…”

Section: Discussioncontrasting

confidence: 56%

“…The integrin pattern of our cells differed in their CD18/integrin β2 and CD51/integrin αV expression. The fvERM outgrowing cells expressed low levels of the α-subunit-containing integrins, besides a reported expression of integrin α4 in DR 123,125 . Interestingly, the presence of integrin β2 subunit has been considered an important factor in RPE-T cell interactions 126 ( Figure 14).…”

Section: Discussionmentioning

confidence: 77%

Genomic and proteomic characterization of physiological and pathological angiogenesis in the human eye

Zoltán¹

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“…The lens is surrounded by an elaborate basement membrane composed of collagen IV, laminin, fibronectin (Cammarata et al, 1986), and a variety of proteoglycans, which are necessary for proper adhesion and migration. Integrins capable of binding these ECM proteins are expressed along fiber cell membranes (Menko and Philp, 1995;Menko et al, 1998;Menko and Walker, 2004). Focal adhesion proteins, such as FAK, MLCK, caldesmon, and paxillin, are arranged at the basal tips of elongating fiber cells in an unusual, two-dimensional array referred to as the basement membrane complex (Bassnett et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development

Song

Sato

Sekiguchi

et al. 2012

Developmental Dynamics

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Background: Adhesion molecules are known to be instructive for both development and differentiation. During lens differentiation, epithelial cells undergo vertical elongation, with the anterior and posterior tips of the elongating fiber cells sliding along the epithelium and capsule, respectively. These cellular processes are highly coordinated through cell adhesive interactions, actin cytoskeletal reorganization and contractile force generation. Alterations in extracellular matrix composition that interfere with these interactions can lead to defects that alter tissue morphogenesis and the state of differentiation. We have demonstrated that Equarin, which is a secreted molecule expressed in the equator region of the lens, plays an important role in chick lens fiber differentiation through fibroblast growth factor signaling. Results: Here, we explored the function of Equarin in chick lens cell adhesion. Equarin protein was expressed in the extracellular region of lens differentiating cells. We found that Equarin promoted lens cell adhesion through heparan sulfate proteoglycan. By biochemical analysis, we found that Equarin directly binds syndecan-3, which displayed a similar expression pattern to Equarin. Overexpression of Equarin resulted in altered actin localization. Conclusions: Equarin is involved in cell adhesion during fiber differentiation and development. Developmental Dynamics 242:23-29,

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β1 Integrins in Epithelial Tissues: A Unique Distribution in the Lens

Cited by 73 publications

References 0 publications

Regulation of cell adhesion and migration in lens development

Regulation of cell adhesion and migration in lens development

Genomic and proteomic characterization of physiological and pathological angiogenesis in the human eye

Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development

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