β2 Adrenergic receptor on T lymphocytes and its clinical implications

Fan, Xue-Lai; Wang, Yuedan

doi:10.1016/j.pnsc.2008.10.001

Cited by 31 publications

(22 citation statements)

References 60 publications

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“…In investigating which specific type(s) of hematopoietic cells are most important in this process, we focused on MDSCs, as they are a relevant population of hematopoietic cells known to be associated with immune suppression and cancer progression. To test whether β2-AR -/deficient MDSCs lose their protumorigenic properties, we depleted MDSCs in both WT and β2-AR -/mice using an anti-Gr-1 antibody (31). MDSC depletion significantly delayed 4T1 tumor growth in WT mice, but led only to a small, nonsignificant decrease tumor growth rate in β2-AR -/mice (Figure 1E).…”

Section: Introductionmentioning

confidence: 99%

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

Mohammadpour¹,

MacDonald²,

Qiao³

et al. 2019

Journal of Clinical Investigation

177

159

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Section: Introductionmentioning

confidence: 99%

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

Mohammadpour¹,

MacDonald²,

Qiao³

et al. 2019

Journal of Clinical Investigation

177

159

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“…, ; Spielmann et al. ) potentially due to greater β 2 ‐adrenergic receptor expression (Fan and Wang ). Senescent and highly differentiated T cells typically lack CD28 expression (Vallejo ; Parish et al.…”

Section: Discussionmentioning

confidence: 99%

“…The T-cell response to exercise is highly dependent on the phenotype studied. It has been well reported that highly differentiated, senescent, and cytotoxic T cells display greater exercise responsiveness than naive and low differentiated T-cell subsets (Simpson et al 2007(Simpson et al , 2010Spielmann et al 2014) potentially due to greater b 2 -adrenergic receptor expression (Fan and Wang 2009). Senescent and highly differentiated T cells typically lack CD28 expression (Vallejo 2005;Parish et al 2010), and thus, these cells can be somewhat identified in human peripheral blood via staining with CD28 antibody.…”

Section: Discussionmentioning

confidence: 99%

Older men display elevated levels of senescence-associated exercise-responsive CD28^nullangiogenic T cells compared with younger men

et al. 2018

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Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative ability. CD31+ T cells (angiogenic T cells; TANG) possess highly angiogenic capabilities; however, these cells are significantly reduced in older populations. In addition, older populations possess significantly higher senescent and highly differentiated T‐cell levels in circulation, and these are reported to be highly exercise responsive. We investigated whether older adults display greater levels of circulating senescent (CD28null) TANG cells and whether these cells were more exercise responsive than CD28+ TANG cells. Young (18–25 years; n = 9) and older (60–75 years; n = 10) healthy men undertook a 30‐min cycling bout at 70% trueV˙O2peak, with circulating TANG cells (CD3+ CD31+ CD28+/null; including CD4+ and CD8+ subsets) measured preexercise, postexercise, and 1 h post exercise by flow cytometry. Older adults displayed reduced basal levels of TANG cells (mean ± SEM: 410 ± 81 vs. 784 ± 118 cells·μL, P = 0.017), despite a greater proportion of these cells being CD28null (26.26 ± 5.08 vs. 13.36 ± 2.62%, P = 0.044). Exercise significantly increased the circulating number of TANG cells in both young and older men. However, in older men alone, exercise preferentially mobilized CD28null CD8+ TANG cells compared with CD28+ TANG cells (time × phenotype interaction: P = 0.022; Δ74 ± 29 vs. Δ27 ± 15 cells·μL, P = 0.059), with no such difference observed between these phenotypes in the young population. In conclusion, this is the first study to demonstrate that despite observing lower circulating numbers of TANG cells, older adults display greater levels of senescent TANG cells in comparison with younger individuals, and these cells are more exercise responsive than CD28+ TANG cells. Lower number of circulating TANG and greater levels of senescent‐associated CD28null TANG may contribute to greater CVD risk with advancing age.

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“…In cord blood T cells exposed to β2-agonists are predisposed towards Th2 direction and Th1 is relatively inhibited [7,12]. During parturition, fetal adrenals produce excessive amount of catecholamines [10].…”

Section: Catecholaminesmentioning

confidence: 99%

Endocrine Factors Determining Immune Polarization during Perinatal Transition

Vásárhelyi

Tulassay

2017

Klin Padiatr

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In utero the skewness of the adaptive immune system towards Th2 ('antiinflammatory') direction and low of Th1/Th2 cell ratio defend the fetus against rejection by the maternal immune system. Th2 dominance at birth is also of importance as it prevents uncontrolled inflammatory processes during parturition. This condition should change rapidly after birth. In an extrauterine milieu that is inherent with exposure to microorganisms, Th1 ('proinflammatory') polarization (i. e. increased Th1 cytokine production along with high Th1/Th2 ratio) are required to maintain an efficient immune response. After birth, maternal hormone supplies including estrogen, progesterone, testosterone, and antiinflammatory prostaglandins cease abruptly. As these hormones have an immune modulatory action favoring Th2, and inhibiting Th1 polarization, their low level supports the strengthening of Th1-type immunity. During parturition a dramatic but transient increase of several hormones (oxytocin, thyorid hormones, and catecholamines) occurs. Again, the net effect of high hormone levels favors Th2 activation, followed by Th1 polarization when hormonal levels reach their postnatal levels. The perinatal change of these components results in the quick cessation of Th1 inhibition and supports the maturation of adaptive immunity to provide an effective response against extrauterine microorganisms.

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β2 Adrenergic receptor on T lymphocytes and its clinical implications

Cited by 31 publications

References 60 publications

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

Older men display elevated levels of senescence-associated exercise-responsive CD28^nullangiogenic T cells compared with younger men

Endocrine Factors Determining Immune Polarization during Perinatal Transition

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β2 Adrenergic receptor on T lymphocytes and its clinical implications

Cited by 31 publications

References 60 publications

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

Older men display elevated levels of senescence-associated exercise-responsive CD28nullangiogenic T cells compared with younger men

Endocrine Factors Determining Immune Polarization during Perinatal Transition

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Older men display elevated levels of senescence-associated exercise-responsive CD28^nullangiogenic T cells compared with younger men