γδ T Cells and Allergic Diseases

Hsu, Uei-Hsiang; Chiang, Bor-Luen

doi:10.1007/s12016-023-08966-0

Cited by 5 publications

(1 citation statement)

References 106 publications

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“…These pathways were also of vital importance in the targets network (Figure 2C, D). Besides, biological processes associated with IFN- were reported closely to allergic diseases represented by AR [31][32][33] , as well as those related to cell adhesion [34][35][36] and T cell [37][38][39] , which aligned with their significant positions within the multi-layered biological networks (Figure 2E, F).…”

Section: Network Target Analysis Of Tzd Against Armentioning

confidence: 88%

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Zhao,

Wang,

Kong

et al. 2024

Preprint

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Background: Increasing evidence showed that seasonal allergic rhinitis (SAR), as an allergy disease, could be alleviated with traditional Chinese medicine (TCM) formula, one example being Tuomin Zhiti Decoction (TZD). However, as a complex composition of TCM herbs, the mechanism of TZD in the treatment of SAR remain unclear. Purpose: Uncover the mechanism of TZD for treating SAR based on computational analysis and clinical multi-omics experiments. Study design: Integrate computational analysis including network target analysis and machine learning algorithms with clinical multi-omics experiments and public omics data. Methods: By analyzing TZD's composition through a network-based method, we identified the biological effects of each compound, constructing a comprehensive biological network to elucidate TZD's molecular and pathway mechanisms against AR. Single-arm clinical trials on the gut microbiome and serum transcriptomics corroborated our computational insights. Further validation through public omics data highlighted key TZD compounds, paving the way for future research. Results: TZD was discovered to exert a regulatory effect on various modules associated with AR, as demonstrated by the constructed biological network. Insights from gut microbiome and serum transcriptomics in clinical trials, where immune-related microbiomes represented by Prevotella, as well as pathways and biological processes including antigen processing and presentation, activation and regulating immune cell surface receptor, were markedly enriched (P value < 0.05), indicated that TZD played a pivotal role in modulating immune processes and the immune cells against AR. With the verification of multi-omics, it was determined that TZD potentially influences immune responses and downstream immune cells like CD4+ T cells, through both direct mechanisms involving antigen and indirect mechanisms mediated by gut microbiomes in the treatment of AR. Conclusion: Through combination of computational prediction and analysis together with clinical multi-omics, a network target based framework provided a new insight for uncovering the mechanism of TZD for treating AR.

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Section: Network Target Analysis Of Tzd Against Armentioning

confidence: 88%

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Zhao,

Wang,

Kong

et al. 2024

Preprint

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Atopic dermatitis: pathogenesis and therapeutic intervention

Yue,

Zhou,

Wang

et al. 2024

MedComm

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The skin serves as the first protective barrier for nonspecific immunity and encompasses a vast network of skin‐associated immune cells. Atopic dermatitis (AD) is a prevalent inflammatory skin disease that affects individuals of all ages and races, with a complex pathogenesis intricately linked to genetic, environmental factors, skin barrier dysfunction as well as immune dysfunction. Individuals diagnosed with AD frequently exhibit genetic predispositions, characterized by mutations that impact the structural integrity of the skin barrier. This barrier dysfunction leads to the release of alarmins, activating the type 2 immune pathway and recruiting various immune cells to the skin, where they coordinate cutaneous immune responses. In this review, we summarize experimental models of AD and provide an overview of its pathogenesis and the therapeutic interventions. We focus on elucidating the intricate interplay between the immune system of the skin and the complex regulatory mechanisms, as well as commonly used treatments for AD, aiming to systematically understand the cellular and molecular crosstalk in AD‐affected skin. Our overarching objective is to provide novel insights and inform potential clinical interventions to reduce the incidence and impact of AD.

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Transcriptional and Microenvironmental Regulation of γδ T Cell Development

Anderson

2024

Reference Module in Life Sciences

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γδ T Cells and Allergic Diseases

Cited by 5 publications

References 106 publications

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Atopic dermatitis: pathogenesis and therapeutic intervention

Transcriptional and Microenvironmental Regulation of γδ T Cell Development

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