ε-Caprolactone in Micro-Chambered Ceramic Beads - A New Carrier for Gentamicin

Abstract

Purpose: The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. Methods: The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatibility and biodegradation of the materials was investigated in an animal experiment in sheep up to 14 months. As carrier ε-caprolactone, 1:1 mixed with gentamicin, intruded into micro-chambered β-tricalcium-phosphate beads (MCB®) was studied. Results and Discussion: Gentamicin was released in calculable concentrations during the first 30 days. The release from ε-caprolactone was higher than that from polymethylmethacrylate and more predictable. The caprolactone carrier was reabsorbed by osteoclasts.

ε-Caprolactone Is Not a 50-kDa Molecule when Applied in Micro-Chambered Beads

“…I am referring to the paper entitled ‘ε-Caprolactone in micro-chambered ceramic beads - a new carrier for gentamicin' by Draenert et al [1] that was published in Chemotherapy in 2013. The materials and methods section as described in the publication confuses me.…”