ε-Viniferin Is More Effective Than Its Monomer Resveratrol in Improving the Functions of Vascular Endothelial Cells and the Heart

Zghonda, Nahla; Yoshida, Shigeki; Ezaki, Shoji; Otake, Yoshie; Murakami, Chie; Mliki, Ahmed; Ghorbel, Abdelwahed; Miyazaki, Hitoshi

doi:10.1271/bbb.110975

Cited by 50 publications

(46 citation statements)

References 37 publications

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“…The up-regulation of 40 genes coding for stilbene synthases together with the accumulation of stilbene glycosides in infected berries and botrytized wine verified the induction of stilbene biosynthesis during noble rot. Some stilbene dimers, in particular «-viniferin glycosides, have been reported to be more effective phytoalexins and to have stronger health-promoting effects than the monomeric stilbenoids (Schouten et al, 2002;Zghonda et al, 2012). The concomitant expression of the stilbene synthases directly correlated with the highly significant up-regulation of the VvMYB14 and VvMYB15 transcription factors, which are the master regulators of the stilbene pathway (Höll et al, 2013).…”

Section: Noble Rot Induction Of Phenylpropanoid Metabolism: Intersectmentioning

confidence: 99%

Developmental and metabolic plasticity of white-skinned grape berries in response to Botrytis cinerea during noble rot

et al. 2015

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Noble rot results from exceptional infections of ripe grape (Vitis vinifera) berries by Botrytis cinerea. Unlike bunch rot, noble rot promotes favorable changes in grape berries and the accumulation of secondary metabolites that enhance wine grape composition. Noble rot-infected berries of cv Sémillon, a white-skinned variety, were collected over 3 years from a commercial vineyard at the same time that fruit were harvested for botrytized wine production. Using an integrated transcriptomics and metabolomics approach, we demonstrate that noble rot alters the metabolism of cv Sémillon berries by inducing biotic and abiotic stress responses as well as ripening processes. During noble rot, B. cinerea induced the expression of key regulators of ripening-associated pathways, some of which are distinctive to the normal ripening of red-skinned cultivars. Enhancement of phenylpropanoid metabolism, characterized by a restricted flux in white-skinned berries, was a common outcome of noble rot and red-skinned berry ripening. Transcript and metabolite analyses together with enzymatic assays determined that the biosynthesis of anthocyanins is a consistent hallmark of noble rot in cv Sémillon berries. The biosynthesis of terpenes and fatty acid aroma precursors also increased during noble rot. We finally characterized the impact of noble rot in botrytized wines. Altogether, the results of this work demonstrated that noble rot causes a major reprogramming of berry development and metabolism. This desirable interaction between a fruit and a fungus stimulates pathways otherwise inactive in white-skinned berries, leading to a greater accumulation of compounds involved in the unique flavor and aroma of botrytized wines.

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Section: Noble Rot Induction Of Phenylpropanoid Metabolism: Intersectmentioning

confidence: 99%

Developmental and metabolic plasticity of white-skinned grape berries in response to Botrytis cinerea during noble rot

et al. 2015

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“…2,26 Studies have demonstrated that two components are neuroprotective and improve vascular function. 27,28 These studies indicated that VT has potential for use in anti-arthritic supplements. The goal of this study was to determine the anti-inflammatory effects against arthritis of the VT extract in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Vitis thunbergii var. taiwaniana on Knee Damage Associated with Arthritis

Tsai

Wang

Chen

et al. 2014

Journal of Medicinal Food

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Vitis thunbergii Sieb. et Zucc. var. taiwaniana Lu (VT) is an indigenous plant in Taiwan that is traditionally used for promoting joint health. In this study, we used in vitro primary human chondrocytes (PHCs) and two in vivo animal models to evaluate the anti-inflammatory effects of VT on arthritis. Results showed that the water extract of the stems and roots from VT (VT-SR) was rich in flavones and phenols with 1.1 mg/g of resveratrol, 6.7 mg/g of hopeaphenol, and 5.1 mg/g of (+)-e-viniferin. VT-SR significantly scavenged DPPH radicals and inhibited prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-induced PHCs without exhibiting significant cytotoxicity. In in vivo models, the VT-SR (500 mg/kg) significantly decreased serum PGE2 and knee 2-18 F-fluoro-2-deoxy-D-glucose ( 18 F-FDG) levels in LPS-induced acute inflammatory arthritis in rabbits. In addition, dietary supplementation with VT-SR for 28 days significantly alleviated type II collagenase-induced rat osteoarthritis with improvements in weight bearing and range of motion tests. In conclusion, our results suggest that the VT-SR is a good candidate for developing dietary supplements to prevent joint deterioration and inhibit inflammation.

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“…Specific Activity (µmol/mg/h) Free laccase 1 7.4 ± 0.5 Free laccase in the presence of copper phosphate crystals 2 7.4 ± 0.3 Free laccase in the presence of copper sulfate 3 8.9 ± 0.4 Laccase in the nanoflowers 4 16.3 ± 0.5 Copper phosphate crystals without laccase 5 0.0 1 Reaction conditions: pH 4.0 buffer containing 11.25 mmol NaCl (15 mL), trans-resveratrol (2 mmol), n-butanol (30 mL), and laccase (5 mg) at 35 • C for 3 days. 2 Reaction conditions: pH 4.0 buffer containing 11.25 mmol NaCl and 46 µmol copper phosphate crystals (15 mL), trans-resveratrol (2 mmol), n-butanol (30 mL), and laccase (5 mg) at 35 • C for 3 days.…”

Section: Enzymementioning

confidence: 99%

“…2 Reaction conditions: pH 4.0 buffer containing 11.25 mmol NaCl and 46 µmol copper phosphate crystals (15 mL), trans-resveratrol (2 mmol), n-butanol (30 mL), and laccase (5 mg) at 35 • C for 3 days. 3 Reaction conditions: pH 4.0 buffer containing 11.25 mmol NaCl and 138 µmol copper sulfate (15 mL), trans-resveratrol (2 mmol), n-butanol (30 mL), and laccase (5 mg) at 35 • C for 3 days.…”

Section: Enzymementioning

confidence: 99%

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Using Laccases in the Nanoflower to Synthesize Viniferin

Zhu

et al. 2017

Catalysts

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Abstract:The laccase-incorporated nanoflower was fabricated and characterized by scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). SEM images indicate that the laccase-incorporated nanoflower has a high surface area, which may facilitate the mass transfer of the substrate and the product. FTIR spectrums identify the existence of laccase in the nanoflowers. The novel immobilized laccase was used for the synthesis of viniferin. The reaction conditions had been optimized and the laccase-incorporated nanoflower can show its maximum specific activity (16.3 µmol/g/h) under the optimal reaction conditions. The specific activity of the laccase in the nanoflowers is enhanced about 2.2-fold compared with free laccase in solution without copper (II) ions. Furthermore, the laccase in the nanoflowers shows an increase in specific activity of~180% compared with free laccase in a solution containing high concentrations (similar to the concentration in the flower) of copper (II) ions. The results also indicate that the laccase in the nanoflowers retain 93.2% of its initial specific activity even after ten continuous batches.

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ε-Viniferin Is More Effective Than Its Monomer Resveratrol in Improving the Functions of Vascular Endothelial Cells and the Heart

Cited by 50 publications

References 37 publications

Developmental and metabolic plasticity of white-skinned grape berries in response to Botrytis cinerea during noble rot

Developmental and metabolic plasticity of white-skinned grape berries in response to Botrytis cinerea during noble rot

Anti-Inflammatory Effects of Vitis thunbergii var. taiwaniana on Knee Damage Associated with Arthritis

Using Laccases in the Nanoflower to Synthesize Viniferin

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