λ-cyhalothrin and cypermethrin induced in vivo alterations in the activity of acetylcholinesterase in a freshwater fish, Channa punctatus (Bloch)

Kumar, Amit; Kumar, Dinesh; Sharma, Bechan; Pandey, Ravi Shankar

doi:10.1016/j.pestbp.2008.12.005

Cited by 57 publications

(35 citation statements)

References 18 publications

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“…Values with different alphabet (uppercase) superscripts differ significantly between tissues within exposure duration and concentration acclimatized for 1 month under laboratory condition before the start of the experiment to remove the residual effects of other chemicals. Several investigators (Pandey et al 2006;Sharma et al 2007;Ali et al 2009;Kumar et al 2009;Nwani et al 2010) have used 0.05% KMnO 4 solution for prophylactic treatment before starting their experiments, and they did not report any adverse effects in test organisms due to prophylactic treatment. Lipid peroxidation (LPO) is also one of the main manifestations of oxidative damage induced by various compounds, including metals (Ercal et al 2001); hence, it has been used as a biomarker of pollution (Sayeed et al 2003;Blaha et al 2004;Almroth et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Assessment of tissue-specific effect of cadmium on antioxidant defense system and lipid peroxidation in freshwater murrel, Channa punctatus

Dabas

Nagpure

Kumar

et al. 2011

Fish Physiol Biochem

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The effects of different concentrations of cadmium chloride on the extent of lipid peroxidation (LPO) and alterations in the antioxidant enzyme activities were studied in liver, kidney and gill tissues of freshwater murrel, Channa punctatus. The fish specimens were exposed to 6.7, 13.4 and 20.1 mg l(-1) sublethal concentrations of cadmium chloride and the oxidative stress was assessed after 24, 48, 72 and 96 h post-exposure. The biomarkers selected for the study were thiobarbituric acid reactive substances for assessing the extent of lipid peroxidation and antioxidant defense system such as reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GP(X)), glutathione-S-transferase (GST), catalase (CAT) and superoxide dismutase (SOD) activities. In general, the cadmium exposure elevated the LPO in subject tissues of treated group and modulated the activities of GPx, GST, SOD, CAT, GR and level of GSH after given exposure as compared to the control. All enzymes activities, except CAT (in kidney and gills), and amount of LPO elevated significantly (P < 0.05) in treated group with respect to control in all tissues, while significant difference was not observed between the exposed concentrations and within exposure duration. The results indicated that increase in LPO level and the fluctuation in antioxidant defense system in fish could be due to cadmium-induced increase in the production of reactive oxygen species (ROS). The potential role of these parameters as biomarkers of heavy metal pollution in aquatic system is discussed.

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Section: Discussionmentioning

confidence: 99%

Assessment of tissue-specific effect of cadmium on antioxidant defense system and lipid peroxidation in freshwater murrel, Channa punctatus

Dabas

Nagpure

Kumar

et al. 2011

Fish Physiol Biochem

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“…Because the OP-AChE reaction is substantially irreversible, relative inhibition of AChE activity is used as a biomarker of exposure to some pesticides (Hyne and Maher 2003). The AChE inhibition leads to behavioral changes, paralysis, and death in aquatic organisms (Fulton and Key 2001;Kumar et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase and metallothionein in oysters (Crassostrea corteziensis) from a subtropical Mexican Pacific estuary

et al. 2010

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Substantial efforts have been devoted to developing and applying biomarkers for ecological risk assessment. Bivalve mollusks, such as mussels and oysters, are commonly used in environmental monitoring programs because of their wide geographical distribution, great sensitivity to environmental pollutants, and ability to accumulate anthropogenically derived chemicals at a high rate. Acetylcholinesterase (AChE) activity and metallothionein (MT's) content are representative specific biomarkers that indicate the presence of anticholinesterasic compounds (like organophosphorus and carbamate pesticides) and metals, respectively. The aim of this study was to evaluate AChE activity and MT's content in Crassostrea corteziensis from Boca de Camichín estuary. The results obtained here showed that AChE activity was 65% lower in oysters from Boca de Camichín than in control organisms. In contrast, MT's content in collected organisms was not statistically different from that in control organisms. AChE activity and MT's content in oysters could be used as early biomarkers of effects and exposure to pesticides and heavy metals, respectively, in aquatic environments.

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“…That difference might be attributed to some factors such as developmental stage, commercial formulation, or even to a species-specific trait. In fish, the toxicity of cypermethrin varies between 0.4 µg L -1 (Bradbury e Coast, 1989) and 400 µg L -1 (Kumar et al, 2009) as depicted in Table 5. Likewise, the LC 50 of deltamethrin and λ-cyhalothrin may vary among fishes (Table 5).…”

Section: Discussionmentioning

confidence: 99%

“…Despite the increased studies on LC 50 of pyrethroids in fish species (Vijayavel & Balasubramanian, 2007;Güner, 2009;Kumar et al, 2009;Kumar et al, 2011), no data are available about the LC 50 of pyrethroids in matrinxa Brycon amazonicus (Spix & Agassiz 1829), a freshwater fish of warm waters. For this purpose, the endpoints considered above the acute toxicity of the type II pyrethroid-based insecticides (PBI) cypermethrin, deltamethrin and λ-cyhalothrin were gauged in the freshwater teleost matrinxa Brycon amazonicus which will provide fundamental data to appropriate regulation of these PBIs.…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity of pyrethroid-based insecticides in the Neotropical freshwater fish Brycon amazonicus

Moraes

Cortella

Rossi

et al. 2024

Ecotoxicol. Environ. Contam.

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Pyrethroids are insecticides widely used in agriculture to control ectoparasites and biological vectors. They can reach the water bodies by leaching and or runoff. Fishes are highly sensitive to pyrethroids and the nervous system sensibility and the deficient drug metabolism are the clues but the toxicity mechanisms are yet unclear. The acute toxicity assays allow evaluating the potential, environmental risks of specific pesticides. Type II pyrethroids are becoming widely used and there is no law concerning the limits of use to this kind of pesticide in Brazil. The LC 50 ;96h was evaluated for three pyrethroid basedinsecticides (PBI): cypermethrin, deltamethrin and λ-cyhalothrin in fish Brycon amazonicus. The LC 50 ;96h for the cypermethrin based-insecticide (CBI) was 36 µg L -1 ; for deltamethrin based-insecticide (DBI) was 2.6 µg L -1 ; and for λ-cyhalothrin (LBI) was 6.5 µg L -1 . During the tests some behavioral alterations were registered just after the exposure; they were more evident at the highest xenobiotics concentrations. These alterations were indicative of asphyxia and nervous system damages. The three insecticides are highly toxics to B. amazonicus and the degree of toxicity is: deltamethrin> λ-cyhalothrin> cypermethrin. The behavioral alterations observed are worrying since long-term exposure to sublethal concentrations can affect survival and reproductive ratios.

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λ-cyhalothrin and cypermethrin induced in vivo alterations in the activity of acetylcholinesterase in a freshwater fish, Channa punctatus (Bloch)

Cited by 57 publications

References 18 publications

Assessment of tissue-specific effect of cadmium on antioxidant defense system and lipid peroxidation in freshwater murrel, Channa punctatus

Assessment of tissue-specific effect of cadmium on antioxidant defense system and lipid peroxidation in freshwater murrel, Channa punctatus

Acetylcholinesterase and metallothionein in oysters (Crassostrea corteziensis) from a subtropical Mexican Pacific estuary

Acute toxicity of pyrethroid-based insecticides in the Neotropical freshwater fish Brycon amazonicus

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