Видовое Разнообразие Нетуберкулезных Микобактерий У Больных Микобактериозом На Территориях Северо-Западного Федерального Округа России*

Старкова, Д. А.; Zhuravlev, Viacheslav; Vyazovaya, Anna; Solovieva, Natalia; KULIKOVА, O. N.; Narvskaya, Olga

doi:10.21292/2075-1230-2019-97-6-16-22

Cited by 8 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…№2 АНТИБИОТИКОРЕЗИСТЕНТНОСТЬ Введение В последние десятилетия на фоне снижения забо леваемости туберкулезом в России наблюдается уве личение частоты случаев микобактериозов, в первую очередь у пациентов с иммунодефицитами как инфек ционной, так и неинфекционной природы [1][2][3]. Среди нетуберкулезных микобактерий (НТМБ), вызывающих заболевания у человека, в России и в мире лидируют медленнорастущие микобактерии, относящиеся к ком плексу Mycobacterium avium (МАК) [4,5]. К МАК отно сятся два вида микобактерий, имеющие клиническое значение, -M. avium и M. intracellulare [6].…”

Section: Objectiveunclassified

Antimicrobial susceptibility of Mycobacterium avium complex mycobacteria isolated from patients in Ural Federal District of the Russian Federation

Umpeleva

Shulgina

Vakhrusheva

et al. 2022

CMAC

View full text Add to dashboard Cite

Objective. To assess minimal inhibitory concentrations (MICs) of antimicrobials for Mycobacterium avium complex (MAC) mycobacteria isolated from patients in Ural Federal District of the Russian Federation. Materials and Methods. We determined MICs for 33 M. avium and 34 M. intracellulare strains isolated from 67 patients with mycobacteriosis or tuberculosis/mycobacteriosis co-infection during 2018– 2019. SLOMYCO Sensititre test-system was used for susceptibility testing to 12 antibiotics: amikacin, streptomycin, clarithromycin, ethambutol, rifabutin, rifampicin, ciprofloxacin, ethionamide, isoniazid, linezolid, moxifloxacin, and doxycycline. Mycobacteria isolates were categorized according to their MICs as “susceptible”, “susceptible with increased exposure to the drug”, and “resistant” using CLSI breakpoints (2018). Breakpoints for amikacin, clarithromycin, linezolid and moxifloxacin were available for M. avium complex, for ciprofloxacin, doxycycline, rifabutin, rifampicin – for slow growing nontuberculous mycobacteria other than MAC mycobacteria. Breakpoints for ethambutol, isoniazid, streptomycin and ethionamide were not available. Results. Rates of susceptibility of M. avium and M. intracellulare were: amikacin – 96.9% and 97.0%, clarithromycin – 84.8% and 97.1%, linezolid – 9.1% and 23.5%, moxifloxacin – 57.6% and 38.2%, respectively. Majority of M. avium and M. intracellulare isolates were resistant to ciprofloxacin, doxycycline, and rifampicin. Ethambutol MICs for 84.4% of M. avium and for 67.7% of M. intracellulare isolates were > 8 mg/L. The majority of studied isolates (64.2%) were susceptible to at least three antimicrobials for the treatment of infections caused by MAC mycobacteria. Conclusions. Macrolides and aminoglycosides were the most effective against MAC mycobacteria in our study. Use of macrolides in combination with rifabutin and amikacin or moxifloxacin and amikacin may increase treatment efficacy in infections caused by M. avium and M. intracellulare.

show abstract

Section: Objectiveunclassified

Antimicrobial susceptibility of Mycobacterium avium complex mycobacteria isolated from patients in Ural Federal District of the Russian Federation

Umpeleva

Shulgina

Vakhrusheva

et al. 2022

CMAC

View full text Add to dashboard Cite

show abstract

Features of cystic fibrosis development in a patient with coinfection by Mycobacterium abscessus and Mycobacterium tuberculosis (clinical case report)

Filinyuk,

Kruk,

Teteneva

et al. 2024

Bûll. sib. med.

View full text Add to dashboard Cite

The article presents a clinical case describing a favorable clinical outcome of mycobacterial infection and pulmonary tuberculosis caused by coinfection of M. abscessus and M. tuberculosis in a patient with pulmonary manifestations of cystic fibrosis one year after delivery. This outcome was achieved due to timely diagnosis and treatment of pulmonary tuberculosis and non-tuberculous mycobacterial infection in the patient with cystic fibrosis. Due to the development of molecular identification of mycobacteria species in the Tomsk region, mycobacterial lung disease was verified, which was challenging in the recent past. Previously, all cases with microscopic examination results positive for mycobacteria were classified as tuberculosis.

show abstract

Drug susceptibility of clinical isolates of Mycobacterium avium complex

Старкова

Zhuravlev

Solovieva

2022

Tuberk. bolezni lëgk.

View full text Add to dashboard Cite

The objective: to study drug susceptibility of M. avium and M. intracellulare isolates received from patients with mycobacteriosis residing in the North Western Federal District using the Sensititre SLOMYCO panels.Subjects and Methods. From 2014 to 2020, 192 slow-growing MAC strains (164 – M. avium, 28 – M. intracellulare) obtained from HIV-negative patients with pulmonary mycobacteriosis were studied. Drug susceptibility testing of MAC strains was performed using the Sensititre SLOMYCO panel consisting of 13 antibacterial drugs.Results. Of the 13 antibacterial drugs, clarithromycin was also most effective against both M. avium (67.1%; 110/164) and M. intracellulare (60.7%; 17/28) (p > 0.05). The proportion of M. avium and M. intracellulare strains sensitive to linezolid was high and amounted to 57.3 and 53.5%, as well as to amikacin – 57.3 and 53.5% respectively.Of the four antibacterial drugs of the Sensititre SLOMYCO panel (clarithromycin, moxiﬂoxacin, linezolid, and amikacin), for which critical concentrations (CC) were established, clarithromycin was the most eﬀective against M. avium and M. intracellulare. Antibiotic-resistant M. avium isolates were more frequent in the group of previously treated patients.

show abstract

Видовое Разнообразие Нетуберкулезных Микобактерий У Больных Микобактериозом На Территориях Северо-Западного Федерального Округа России*

Cited by 8 publications

References 13 publications

Antimicrobial susceptibility of Mycobacterium avium complex mycobacteria isolated from patients in Ural Federal District of the Russian Federation

Antimicrobial susceptibility of Mycobacterium avium complex mycobacteria isolated from patients in Ural Federal District of the Russian Federation

Features of cystic fibrosis development in a patient with coinfection by <em>Mycobacterium abscessus</em> and <em>Mycobacterium tuberculosis</em> (clinical case report)

Drug susceptibility of clinical isolates of <i>Mycobacterium avium</i> complex

Contact Info

Product

Resources

About