Вміст Лептину У Сироватці Крові Вагітних Жінок З Ожирінням У Ііі Триместрі Вагітності

Семенина, Галина; Фартушок, Тетяна; Старикович, Анна

doi:10.36074/grail-of-science.19.02.2021.095

Cited by 14 publications

(2 citation statements)

References 1 publication

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“…Chloroquine is not known to interact adversely with DRA. In fact, it has been shown to induce cell apoptosis in pituitary tumors when used in combination with cabergoline in animal studies [8]. However, these beneficial effects are unlikely to be observed during short exposure [2].…”

Section: S Ect Io N X Ix M Ed Ic Al Sci E Nc Es and P Ubl Ic Healthmentioning

confidence: 99%

Features of the Course of Covid-19 in Women With Hyperprolactinemia

Semenyna

Фартушок

Perfun

et al. 2022

GoS

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The 2019 coronavirus pandemic is a major stressful event. In turn, stressful situations are triggers for the exacerbation of existing and activation of new diseases caused by a violation of the immune response in the human body and the development of inflammatory diseases. A stressful state causes the release of stress-mediated hormones, which in turn contributes to an increase in the level of PRL. Obviously, it is a closed circle. Therefore, the questions become relevant: 1. Can stress against the background of Covid-19 really cause an increase in the level of PRL? 2. Can Sovid-19 worsen the course of an already existing HP? Purpose: to conduct an analysis of available medical research on the peculiarities of the course of Covid-19 in women with HP, highlighting research on this topic in order to systematize new views on the diagnosis and treatment of Covid-19 against the background of already existing HP. Materials and methods. 10 articles from 2018 to 2022 with the keywords prolactin, hyperprolactinemia and Covid-19 were analyzed. Research results and their discussion. A review and analysis of a closed cohort study in which 30 men and 15 women participated and passed the Trier social stress test showed that PRL levels were significantly increased in response to a stressor [10], which could be the Covid-19 pandemic. In SARS-CoV-2, the defined receptor binding domain of the viral membrane protein uses angiotensin-converting enzyme 2 (ACE2) as a receptor for virus-host membrane fusion [2]. ACE2 regulates the activity of dopamine decarboxylase (DDC), which is responsible for the synthesis of dopamine and serotonin. Thus, SARS-CoV-2 disrupts the biosynthesis of dopamine, which leads to an increase in the level of PRL. With Covid-19, the expression of TLR4 and NF-κB is activated and increases the induction release of pro-inflammatory cytokines with the development of ALI, ARDS and cytokines with MOF. Conclusions Based on the studies described above, it can be concluded that Covid-19 inhibits the synthesis of dopamine and thus increases the level of prolactin. Also, prolactin can exhibit both immunostimulating and immunosuppressive, as well as pro-inflammatory and anti-inflammatory effects. Treatment with agonists of dopamine receptors can lead to deepening of depression in Covid-19. Treatment of hyperprolactinemia should be carried out with caution, because in critically ill patients who require personal support, the use of amine derivatives with DRA can cause additional vasospasm and, as a result, a rapid increase in blood pressure.

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Section: S Ect Io N X Ix M Ed Ic Al Sci E Nc Es and P Ubl Ic Healthmentioning

confidence: 99%

Features of the Course of Covid-19 in Women With Hyperprolactinemia

Semenyna

Фартушок

Perfun

et al. 2022

GoS

Self Cite

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“…Summarizing all the studies, several mechanisms of IR formation in patients with PCOS can be distinguished: genetic predisposition, violation of insulin secretion by beta cells of the pancreas, peripheral insulin resistance caused by the action of androgens on skeletal muscles, violation of insulin metabolism in the liver, serine phosphorylation of the insulin receptor, and others disturbance in the way of insulin signal transduction into the cell. An important role in the development of IR belongs to hyperandrogenism [4], since androgens change the structure of muscles due to the predominance of type 2 muscle fibers, which are less sensitive to insulin. History of obesity, most often visceral, worsens insulin sensitivity in approximately 50% of patients [5].…”

Section: Introductionmentioning

confidence: 99%

Study of the Effectiveness of Diet Therapy in the Correction of Metabolic Parameters in Women With Polycystic Ovary Syndrome and Insulin Resistance

Semenyna

Фартушок²,

Кomarnitska³

2023

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Taking into account the importance of correction of metabolic parameters in PCOS, diet therapy is offered. Diet therapy is appropriate as the first stage of treatment in patients with PCOS and IR, but the optimal diet has not been determined at the moment [8]. Purpose: to conduct an analysis of studies on the effectiveness of various types of diet therapy. Materials and methods. 12 articles from 2020 to 2022 were analyzed. Research results and their discussion. A review and analysis of a cohort study on the effects of a ketogenic diet (KD), in which 14 overweight women with a diagnosis of PCOS participated [1].The main argument for the use of KD in PCOS and IR is physiological ketosis [4], which occurs as a result of a low carbohydrate content in the diet, which in turn reduces the level of circulating insulin, and therefore the receptor for insulin-like growth factor type 1. As a result, production of androgens in both ovaries and adrenal glands is inhibited.The results of a 12-week study suggest that a ketogenic diet is appropriate for correcting metabolic disorders and obesity in PCOS and IR.The Mediterranean diet (MED) has proven to be one of the most effective diets in the treatment of metabolic and reproductive problems in women with PCOS and IR [5].The results of the research showed that both approaches to diet therapy are productive in normalizing metabolic processes. It is worth noting that the group of patients who used the MED/LC diet combination showed excellent results in the normalization of the menstrual cycle (86.7% recovered a regular menstrual cycle).Соnclusions. The advantages of KD are a good result in reducing weight and anthropometric indicators in a short period of time. The most promising in the context of PCOS and IR treatment with further introduction into the patients' lifestyle is the Mediterranean diet.

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Correction of Glucose Homeostasis Using Dietary Methods in Gestational Diabetes Mellitus

Liubchyk,

Babak

2024

VPBM

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Вміст Лептину У Сироватці Крові Вагітних Жінок З Ожирінням У Ііі Триместрі Вагітності

Cited by 14 publications

References 1 publication

Features of the Course of Covid-19 in Women With Hyperprolactinemia

Features of the Course of Covid-19 in Women With Hyperprolactinemia

Study of the Effectiveness of Diet Therapy in the Correction of Metabolic Parameters in Women With Polycystic Ovary Syndrome and Insulin Resistance

Correction of Glucose Homeostasis Using Dietary Methods in Gestational Diabetes Mellitus

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