Through a comprehensive review of published reports on mycotoxin removal strategies, this work aims to update the understanding of the removal of mycotoxins present in the feed. Mycotoxins in feed: from prevention in the field to detoxification by adsorption or transformation. Mycotoxins are secondary metabolites present worldwide in agricultural products and produced by fungi that cause a toxic response (mycotoxicosis) when ingested by animals. Prevention of mycotoxicosis includes strategies before and after harvesting. The best way to reduce the content of mycotoxins in the feed is to prevent the formation of mycotoxins, but it is often not enough, so other methods are needed. The most common approach in the feed industry is the inclusion of sorbing materials in the feed, which provides more or less selective removal of toxins by adsorption during passage through the gastrointestinal tract. Another reliable approach is the addition of enzymes or microorganisms that can remove toxins from some mycotoxins.