野生动物(野鸟)对全球耐药基因传播的影响

Abstract

Antimicrobial resistance is an urgent global health challenge in human and veterinary medicine. Wild animals are not directly exposed to clinically relevant antibiotics; however, antibacterial resistance in wild animals has been increasingly reported worldwide in parallel to the situation in human and veterinary medicine. This underlies the complexity of bacterial resistance in wild animals and the possible interspecies transmission between humans, domestic animals, the environment, and wildlife. This review summarizes the current data on expanded-spectrum β-lactamase (ESBL), AmpC β-lactamase, carbapenemase, and colistin resistance genes in Enterobacteriaceae isolates of wildlife origin. The aim of this review is to better understand the important role of wild animals as reservoirs and vectors in the global dissemination of crucial clinical antibacterial resistance. In this regard, continued surveillance is urgently needed worldwide.

International clones of extended‐spectrum β‐lactamase (CTX‐M)‐producingEscherichia coliin peri‐urban wild animals, Brazil

“…ESBL-producing E. coli in wild animals begun to be documented in 2006, in Portugal (Costa et al, 2006), and then were rapidly observed in other countries from Europe, Africa, Asia, South America, North America and Australia (Allen et al, 2010;Wang et al, 2017).…”

“…While the exposure to polluted environments constitutes a risk factor for humans to acquire multidrug-resistant (MDR) bacteria, recent studies have pointed out that it could also have implications for wildlife (Cerdà-Cuéllar et al, 2019;Sellera, 2019;Wang et al, 2017). In fact, although this matter remains poorly addressed under ecological perspectives, the scientific community and nature conservation authorities have begun to see wild animals as reservoirs and potential disseminators of ESBL-producing bacteria (Ardiles-Villegas, González-Acuña, Waldenström, Olsen, & Hernández, 2011;Cerdà-Cuéllar et al, 2019;Sellera, 2019;Wang et al, 2017).…”

MCR-1 Colistin Resistance in Escherichia coli Wildlife: A Continental Mini-review

“…The development of bacterial resistance is a naturally occurring evolutionary mechanism of micro-organisms, but the wide spread use and misuse of antibacterial agents in humans and animals has accelerated this process. MCR-1 is one of the few and clear example of the animal origin of a resistance trait that may later hit the entire human health [2,15].…”

“…Wild birds and animals are the potential reservoirs and vectors for the global distribution of MCR-1, it has been identified on Enterobacteriaceae isolates from food-producing animals, companion animal, food products, the environment and humans worldwide [2,19].…”

“…Antimicrobial resistance is one of the notoriously leading issue and universal threat to one health in this era. WHO and US Centers for Disease Control and Prevention are clearly stating about medical science going towards pre-antibiotic era [1].The specific markers of resistance ESBLs , Carbapenemases and mcr-1 genes are helping in prevailing resistance among bacterial strains [2].The discovery of plasmid mediated colistin resistance in the normal and routinely survey of China is devastating finding to one health [1].Then the rash of reports started globally in alarming the human and as well animals health [3].Within just three months of first discovery in November 2015,the spread of MCR-1 gene evidently supported by medical society worldwide [4].Isolation of MCR-1 gene from different locations and samples raised up the need to understand mechanisms underlying in spreading it globally, especially samples from Humans, animals and environment i.e. soil, river water [3,4].…”