and/or their next of kin were informed, and written consent authorizing the use of biological samples was documented in the medical records of the patients by the investigator. The observational study Myelochondria is registered under the ClinicalTrials.gov identifier NCT04439617. General methods statements. No samples, mice, or studies were removed from the analyses, with the exception of unexpected premature death during CLP or i.p. LPS injection experiments. Experiments were not blinded and samples were not randomized in this study. Tissue culture samples were evaluated for mycoplasma contamination.

Highlights d LXR agonists selectively increase IL1B mRNA levels in human macrophages in vitro d The impact of LXR on IL-1b is dependent on HIF-1a d LXR agonists activate other HIF-1a-dependent pathways, including glycolysis d IL1B induction by atheroma plaque homogenates is blunted by LXR antagonists