All antipsychotic side effects, present or past, can have a durable negative impact on patient's attitude toward antipsychotic treatment and adherence. Non-adherence is mainly determined, among other factors, by these negative attitudes, which are partly influenced by the experience of past or present antipsychotic-induced side effects.

The proportion of patients who met combined remission or recovery criteria is low. Early treatment adaptations in case of early non-remission are mandatory.

questions (1) how is remission defined? (2) how many patients achieve remission? and (3) which parameters predict remission? Several prospective and retrospective studies in first-1-4 and multiple-episode patients 5-8 provided definitions for remission using a wide range of criteria and time periods during which the criteria must be maintained. 9,10 The lack of consistent definitions of remission and the heterogeneity of assessed populations thereby hampered cross-study comparisons and limited the generalizability of these results. 9 Most recently, in accordance with previous studies, 1-8 the Remission in Schizophrenia Working Group published a consensus statement on the criteria and the time frame of remission in schizophrenia. 9 Remission was defined as a state of no greater than low-to-mild intensity in core symptoms, sustained for a minimum duration of 6 months. These criteria were recently applied in a 1-year

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