No abstract

This study confirmed both the efficacy and the safety of IL-1Ra in a large cohort of patients with active and severe RA. IL-1Ra is the first biologic agent to demonstrate a beneficial effect on the rate of joint erosion.

SUVc is more efficient than MLVc in reducing the severity of inflammation and joint destruction in rat AIA, and is associated with the specific elimination of macrophage subpopulations from the SM.

Objective. Local interaction between soluble mediators within the inflamed synovium is a key factor that governs the pathologic outcome of inflammatory arthritides. Our aim was to investigate the interplay between the Th1 lymphokine interferon-␥ (IFN␥) and pivotal cytokines that drive rheumatoid arthritis ( ) mice. Joint swelling was measured and histologic analysis was performed in order to assess changes in both inflammatory and degenerative parameters in vivo. In vitro, the influence of IFN␥ in regulating IL-1␤-and TNF␣-driven CXCL8 and CCL2 production was quantified by enzyme-linked immunosorbent assay.Results. In murine AIA, both inflammatory and degenerative arthritis parameters were significantly exacerbated in the absence of IFN␥. IFN␥ appeared to be a crucial factor in regulating CXCR2؉ neutrophil influx in the joint. In in vitro studies using RA fibroblastlike synoviocytes, IFN␥ modulated both IL-1␤-and TNF␣-driven chemokine synthesis, resulting in the down-regulation of CXCL8 production.Conclusion. IFN␥ exerts antiinflammatory, chondroprotective, and antiosteoclastogenic effects in murine AIA through a mechanism that involves the regulation of chemokine synthesis and local neutrophil recruitment. These studies suggest a potential therapeutic role of modulating IFN␥ signaling in the treatment of inflammatory arthritides.