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In this paper we study widely-linear precoding techniques to mitigate in-phase/quadrature-phase (IQ) imbalance (IQI) in the downlink of large-scale multiple-input multiple-output (MIMO) systems. We adopt a real-valued signal model which takes into account the IQI at the transmitter and then develop widely-linear zero-forcing (WL-ZF), widely-linear matched filter (WL-MF), widely-linear minimum mean-squared error (WL-MMSE) and widely-linear block-diagonalization (WL-BD) type precoding algorithms for both single-and multiple-antenna users. We also present a performance analysis of WL-ZF and WL-BD. It is proved that without IQI, WL-ZF has exactly the same multiplexing gain and power offset as ZF, while when IQI exists, WL-ZF achieves the same multiplexing gain as ZF with ideal IQ branches, but with a minor power loss which is related to the system scale and the IQ parameters. We also compare the performance of WL-BD with BD. The analysis shows that with ideal IQ branches, WL-BD has the same data rate as BD, while when IQI exists, WL-BD achieves the same multiplexing gain as BD without IQ imbalance. Numerical results verify the analysis and show that the proposed widely-linear type precoding methods significantly outperform their conventional counterparts with IQI and approach those with ideal IQ branches. Index TermsIQ imbalance, large-scale MIMO, widely-linear signal processing, downlink precoding W. Zhang is with Jiangsu University, China. He was with CETUC, PUC-Rio, Brazil.

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The aim of this systematic review was to characterize the clinical features of adults with Salmonella osteomyelitis and summarize diagnosis and treatment methods to provide guidance for clinicians. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We conducted a literature search in the PubMed, EMBASE, and Cochrane Library databases. Article screening and data extraction were performed by two reviewers individually. All the included studies were independently evaluated by two reviewers using the Methodological Index for Non-Randomized Studies (MINORS) criteria. A total of 67 articles published between 1970 and 2019 were selected, which include 69 patients with an average age of 47.5 years (range, 18-79).The majority of cases (47.76%) occurred in immunocompetent adults without common risk factors. Aspiration and biopsy cultures were all positive in Salmonella osteomyelitis patients who underwent aspiration or biopsy. All infections were monomicrobial, and a total of 12 different serotypes were identified. The three most commonly reported Salmonella serotypes were Salmonella typhi (19 cases), Salmonella typhimurium (12 cases), and Salmonella enteritidis (11 cases). Only 12 of the 67 cases in our data (17.91%) had diarrhea symptoms, and 44 of the 67 cases (65.67%) had fever symptoms. Fifty-nine of the 67 cases (88.06%) had local inflammatory manifestations, such as erythema, swelling, and tenderness in the affected area. The commonly reported involved sites were the vertebrae, femur, and tibia. Antibiotic therapy alone was utilized in 30 cases, and 24 patients (80.00%) were eventually cured. In total, 75.68% of patients achieved satisfactory results after treatment with surgery and antibiotics. Third-generation cephalosporins were most commonly utilized, and antibiotic treatment was administered for an average of 11.3 weeks (95% CI, 8.31-14.37 weeks). Salmonella osteomyelitis should be considered in patients without any common risk factors. Aspiration or biopsy can facilitate the identification of pathogens to guide antibiotic choice. Empirical therapy with a third-generation cephalosporin is recommended until the susceptibility of the strain is determined.