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The most investigated semiconductor photosensor for MRIcompatible PET detectors is the avalanche photodiode (APD). However, the silicon photomultiplier (SiPM), also called the Geiger-mode APD, is gaining attention in the development of the next generation of PET/MRI systems because the SiPM has much better performance than the APD. We have developed an MRI-compatible PET system based on multichannel SiPM arrays to allow simultaneous PET/MRI. Methods: The SiPM PET scanner consists of 12 detector modules with a ring diameter of 13.6 cm and an axial extent of 3.2 cm. In each detector module, 4 multichannel SiPM arrays (with 4 · 4 channels arranged in a 2 · 2 array to yield 8 · 8 channels) were coupled with 20 · 18 Lu 1.9 Gd 0.1 SiO 5 :Ce crystals (each crystal is 1.5 · 1.5 · 7 mm) and mounted on a charge division network for multiplexing 64 signals into 4 position signals. Each detector module was enclosed in a shielding box to reduce interference between the PET and MRI scanners, and the temperature inside the box was monitored for correction of the temperature-dependent gain variation of the SiPM. The PET detector signal was routed to the outside of the MRI room and processed with a field programmable gate array-based data acquisition system. MRI compatibility tests and simultaneous PET/MRI acquisitions were performed inside a 3-T clinical MRI system with 4-cm loop receiver coils that were built into the SiPM PET scanner. Interference between the imaging systems was investigated, and phantom and mouse experiments were performed. Results: No radiofrequency interference on the PET signal or degradation in the energy spectrum and flood map was shown during simultaneous PET/MRI. The quality of the MRI scans acquired with and without the operating PET showed only slight degradation. The results of phantom and mouse experiments confirmed the feasibility of this system for simultaneous PET/MRI. Conclusion: Simultaneous PET/MRI was possible with a multichannel SiPM-based PET scanner, with no radiofrequency interference on PET signals or images and only slight degradation of the MRI scans. A hybrid PET/MRI scanner has many potential advantages, including a reduced radiation dose, better soft-tissue contrast on MRI than CT, an almost unlimited combination of functional and molecular information, and possible motion correction of the PET image using MRI data (1-4). However, simultaneous PET/MRI with a conventional photomultiplier tube (PMT)-based PET camera is technically challenging, because the PMT is highly sensitive to the magnetic field. Almost every property of the PMT PET signal is distorted within the magnetic field. For example, the energy spectrum of the PET detector is quite diminished because of the loss of PMT signal output, and the peak position of the scintillation crystal cannot be distinguished in the flood maps of block detectors (1). Therefore, if relatively long optical fiber bundles are not used, the PMT PET camera should be placed a distance from the MRI machine (5). Consequently, a longer scan time is...

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We integrate multiple, independently addressable piezoelectric thin-film actuators into complex, 3D mesostructures.