Cultural and geographical properties of the environment have been shown to deeply influence cognition and mental health [1][2][3][4][5][6]. While living near green spaces has been found to be strongly beneficial [7][8][9][10][11], urban residence has been associated with a higher risk of some psychiatric disorders [12-14] (although see [15]). However, how the environment one grew up in impacts later cognitive abilities remains poorly understood. Here, we used a cognitive task embedded in a video game [16] to measure non-verbal spatial navigation ability in 397,162 people from 38 countries across the world. Overall, we found that people who grew up outside cities are better at navigation. More specifically, people were better at navigating in environments topologically similar to where they grew up. Growing up in cities with low Street Network Entropy (e.g. Chicago) led to better results at video game levels with a regular layout, while growing up outside cities or in cities with higher Street Network Entropy (e.g. Prague) led to better results at more entropic video game levels. This evidences the impact of the environment on human cognition on a global scale, and highlights the importance of urban design on human cognition and brain function.

Influential theories postulate distinct roles of catecholamines and acetylcholine in cognition and behavior. However, previous physiological work reported similar effects of these neuromodulators on the response properties (specifically, the gain) of individual cortical neurons. Here, we show a double dissociation between the effects of catecholamines and acetylcholine at the level of large-scale interactions between cortical areas in humans. A pharmacological boost of catecholamine levels increased cortex-wide interactions during a visual task, but not rest. An acetylcholine boost decreased interactions during rest, but not task. Cortical circuit modeling explained this dissociation by differential changes in two circuit properties: the local excitation-inhibition balance (more strongly increased by catecholamines) and intracortical transmission (more strongly reduced by acetylcholine). The inferred catecholaminergic mechanism also predicted noisier decision-making, which we confirmed for both perceptual and value-based choice behavior. Our work highlights specific circuit mechanisms for shaping cortical network interactions and behavioral variability by key neuromodulatory systems.

Cultural and geographical properties of the environment have been shown to deeply influence cognition and mental health. However, how the environment experienced during early life impacts later cognitive abilities remains poorly understood. Here, we used a cognitive task embedded in a video game to measure non-verbal spatial navigation ability in 442,195 people from 38 countries across the world. We found that on average, people who reported having grown up in cities have worse navigation skills than those who grew-up outside cities, even when controlling for age, gender, and level of education. The negative impact of cities was stronger in countries with low average Street Network Entropy, i.e. whose cities have a griddy layout. The effect was smaller in countries with more complex, organic cities. This evidences the impact of the environment on human cognition on a global scale, and highlights the importance of urban design on human cognition and brain function.