Carbonate commonly accumulates in weathering profiles developed on noncalcareous parent material under arid and semiarid climatic conditions. Such weathering profile types are widespread in Morocco, making it critical to know the sources of the calcium in order to understand the genesis of carbonate‐rich soils. In this study, we use 87Sr/86Sr as a geochemical tracer of the Ca sources in weathering profiles developed on volcanic rocks (basalt, tuff, andesite and latite) in the Mediterranean coast of Morocco. The results show that the most of the Sr, and hence Ca, is of an external origin, derived from (i) sea‐water for the profiles located near to the coast or (ii) sea‐water plus Liassic carbonate outcropping in the catchment for the profiles more distant from the coastline. The contribution of the host rock is small, being less than 25%. The ratio of the Sr (Ca) from the parent material to that from the external sources is controlled by the degree of porosity developed in the profile.

The commensal bacterial strains used in this study induced the expression of a large number of genes in colonocyte-like cultured cells and changed the expression of several genes involved in important cellular processes such as regulation of transcription, protein biosynthesis, metabolism, cell adhesion, ubiquitination, and apoptosis. Such changes induced by the presence of probiotic bacteria may shape the physiologic and pathologic responses they trigger in the host.

Capturing the past and present hydro-mechanical behavior of passive margin sediments raises noticeable interest, notably in geo-hazard risk assessment and hydrocarbon exploration. In this work, we aim at assessing the stress states undergone by these sedimentary deposits through geological time. To do so, we use an iterative coupling between a basin simulator and a finite element mechanical solver. This method conciliates a computation of the full stress tensors with a dynamic and geologically detailed modelling of the sedimentation. It is carried out on a dedicated set of 2D synthetic basin models, designed to be representative of siliciclastic deposition in passive margins and integrating variations in their geological history. Contrary to common assumptions in operational basin modelling studies, our results imply that passive margin sedimentary wedges are multidimensional mechanical systems, which endure significant non-vertical stress without external tectonic input. Our results also highlight the variability of the stress states through space and time, with a strong control from the geometry and lithological heterogeneities of the deposits. Lastly, we used the simulation results to predict a location and timing for the development of weakness zones in the sedimentary stacks, as privileged areas for rock failure. The outcome underlines the influence of the basal tilt angle, with a slight tilt impacting the wedges stability to a similar extent as a substantial increase in sedimentation rate. Altogether, this study emphasizes the need for careful consideration of non-vertical stresses in basin simulations, including in passive tectonic contexts. It also suggests that the iterative coupling method employed is a promising way to match industrial needs in this regard.

Aim : To test the therapeutic efficacy of octreotide administered subcutaneously for the relief of chronic refractory epigastric pain severe enough to provoke nutritional impairment. Subjects and methods : Seventeen patients were enrolled in an open trial. Epigastric pain had lasted from 1 to 8 years (median: 5 years), following anti‐reflux surgery in eight patients. Median weight loss was 10% (range 10–15). The initial dose of octreotide was 50 μg b.d, adjusted during the follow‐up visits which were scheduled for months 1, 3, 6, 8, 10, 12 and every 3 months. At each visit, overall symptomatic improvement, frequency and intensity of symptoms were checked on a 10‐cm visual analogic scale. Results : At month 1, a progressive improvement of pain intensity was reported in 15 of the 17 patients, while octreotide was a therapeutic failure in two. In four out of 15, the daily dose of octreotide was increased to 100 μg b.d. In these 15 patients, median follow‐up was 7 months (3–27). The symptomatic benefit was maintained in each patient at month 3, with a median weight gain of 3.5 kg.2–5 An attempt to stop octreotide led to recurrence of symptoms in 2–3 days which were as intense as before the treatment. The 11 patients followed‐up for at least 6 months reported persistent improvement of symptoms with octreotide and a median weight gain of 4 kg.3–7 Four patients were followed up for more 11–27 months: octreotide was withdrawn gradually in two who remained asymptomatic. Six of the 17 patients experienced minor side‐effects, but none developed biliary sludge. Conclusions : This open study suggests that octreotide could be a promising alternative treatment when all others fail in refractory chronic functional epigastric pain severe enough to limit food intake and to induce nutritional impairment. These results must be tested by a placebo‐controlled study.