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Kidney transplantation from living kidney donors (LKDs) because of its good results represents a good option for the treatment of patients with the end-stage renal disease. Kidney donation is a relatively safe procedure according to several studies. We conducted this cross-sectional study in order to describe the demographic, clinical, and renal outcome of LKD in Côte d'Ivoire. From March to November 2014, LKD residing in Côte d'Ivoire at the time of investigation and having donated the kidney more than one year ago were considered for the study. They were evaluated through a questionnaire. Of the 29 LKD listed in Côte d'Ivoire, only 14 responded to the questionnaire. The mean age at donation was 43.29 ± 9.12 years (27-59) and 10 of the LKD were women. Eight were related to the recipients, and the remaining were spouses. Laparoscopic nephrectomy was performed in nine LKD. The left kidney was harvested in ten cases. The main motivation for donation in all donors was the desire to save a life. At the time of the survey, the average duration after the donation was 4.57 ± 2.56 years (1-8). Only five donors had a regular nephrological follow-up. Hypertension was observed in one donor, seven had significant proteinuria, and six had glomerular filtration rate <60 mL/min but >30 mL/min. Significantly higher proteinuria was noted in donors under 45 years as compared to those over 45 years (0.43 ± 0.17 g/24 h vs. 0.22 ± 0.03 g/24 h, P = 0.01). Our study suggests that renal disease in LKD in Côte d'Ivoire is low after a mean follow-up period of four years. A donor registry is essential to ensure better follow-up of donors in order to detect potential adverse effects of kidney donation in the medium as well as in the long-term.

Chronic renal failure (CRF) occurring in sickle cell disease has a dismal outcome. The systematic screening for microalbuminuria represents the touchstone to prevent CRF in patients with diabetes mellitus. Microalbuminuria has also been demonstrated in patients with sickle cell disease. Whether this has the same prognostic significance as it does in diabetes mellitus has never been clearly stated. The purpose of the present study was to determine the prevalence of microalbuminuria and to establish the clinical significance of microalbuminuria in patients with sickle cell disease. Patients with sickle cell disease of both sexes and all ages were consecutively recruited at the haematology outpatient clinic of the Yopougon Teaching Hospital, Abidjan, Ivory Coast. in a prospective study from July to September 2004. In each patient characteristics such as age, gender, ethnic group, weight, height, blood pressure, type of haemoglobinopathy , glomerular filtration rate, complications related to the disease and current treatment were collected. Microalbuminuria was assessed in all the patients. Statistical analysis was performed to identify factors related to microalbuminuria. The prevalence of microalbuminuria was 17.3% in our study population. Glomerular filtration rate was significantly lower in the microalbuminuric group than in the normoalbuminuric group both on univariate analysis (p<0.01) and on multivariate analysis (OR=1.074) CI 95% [1.020 1.136]) (p<0.01). Height was significantly lower in the microalbuminuric group than in the normoalbuminuric group both on univariate analysis (p=0.05) and on multivariate analysis (OR=1.029 CI 95% [1.003 1.056])(p<0.05). Anaemia was more prevalent in the microalbuminuric group than in the normoalbuminuric group(p<0.05) on univariate analysis but not on multivariate analysis. No relationship has been found between microabuminuria and age, as well as with disease duration and body mass index. Microalbuminuria in sickle cell disease patients represents a feature of more advanced disease as it is significantly related to low glomerular filtration rate. The high prevalence of anaemia in the microalbuminuric patients corroborates the depressed renal function. The role of short height in the promotion of microalbuminuria is unclear.