Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate promising results, many practical and mechanistic issues regarding this therapy remain highly controversial. Here, we report the results of a randomized study of bone-marrow-derived mesenchymal stem cells, administered to pigs, which offer several new insights regarding cellular cardiomyoplasty. First, cells were safely injected by using a percutaneous-injection catheter 3 d after myocardial infarction. Second, cellular transplantation resulted in long-term engraftment, profound reduction in scar formation, and near-normalization of cardiac function. Third, transplanted cells were preprepared from an allogeneic donor and were not rejected, a major practical advance for widespread application of this therapy. Together, these findings demonstrate that the direct injection of cellular grafts into damaged myocardium is safe and effective in the periinfarct period. The direct delivery of cells to necrotic myocardium offers a valuable alternative to intracoronary cell injections, and the use of allogeneic mesenchymal stem cells provides a valuable strategy for cardiac regenerative therapy that avoids the need for preparing autologous cells from the recipient.

The Canadian Galactic Plane Survey (CGPS) is a project to combine radio, millimetre and infrared surveys of the Galactic Plane to provide arc-minute scale images of all major components of the interstellar medium over a large portion of the Galactic disk. We describe in detail the observations for the low-frequency component of the CGPS, the radio surveys carried out at the Dominion Radio Astrophysical Observatory (DRAO), and summarize the properties of the merged database of surveys that comprises the CGPS.The DRAO Synthesis Telescope surveys have imaged a 73 • section of the Galactic Plane, using ∼85% of the telescope time between April 1995 and June 2000. The observations provide simultaneous radio continuum images at two frequencies, 408 MHz and 1420 MHz, and spectralline images of the λ21-cm transition of neutral atomic hydrogen. In the radio continuum at 1420 MHz dual-polarization receivers provide images in all four Stokes parameters. The surveys cover the region 74.2 • < < 147.3 • , with latitude extent of −3.6 • < b < +5.6 • at 1420 MHz and −6.7 • < b < +8.7 • at 408 MHz. By integration of data from single-antenna observations, the survey images provide complete information on all scales of emission structures down to the resolution limit, which is just below 1 × 1 cosec(δ) at 1420 MHz, and 3.4 × 3.4 cosec(δ) at 408 MHz. The continuum images have dynamic range of several thousand, yielding essentially noise-limited images with rms of ∼0.3 mJy/beam at 1420 MHz and ∼3 mJy/beam at 408 MHz. The spectral-line data are noise limited with rms brightness temperature ∆T B ∼ 3 K in a 0.82 km s −1 channel.The complete CGPS data set, including the DRAO surveys and data at similar resolution in 12 CO (1-0) and in infrared emission from dust, all imaged to an identical Galactic co-ordinate grid and map projection, are being made publicly available through the Canadian Astronomy Data Centre.

Science, 326, Issue 5958, pp. 1379-1382 (2009)International audienc