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Background There is a lack of evidence regarding the benefits of β-blocker treatment after invasively managed acute myocardial infarction (MI) without reduced left ventricular ejection fraction (LVEF). Methods and results TREatment with Beta-blockers after myOcardial infarction withOut reduced ejection fraction (REBOOT) trial is a pragmatic, controlled, prospective, randomized, open-label blinded endpoint (PROBE design) clinical trial testing the benefits of β-blocker maintenance therapy in patients discharged after MI with or without ST-segment elevation. Patients eligible for participation are those managed invasively during index hospitalization (coronary angiography), with LVEF >40%, and no history of heart failure (HF). At discharge, patients will be randomized 1:1 to β-blocker therapy (agent and dose according to treating physician) or no β-blocker therapy. The primary endpoint is a composite of all-cause death, nonfatal reinfarction, or HF hospitalization over a median follow-up period of 2.75 years (minimum 2 years, maximum 3 years). Key secondary endpoints include the incidence of the individual components of the primary composite endpoint, the incidence of cardiac death, and incidence of malignant ventricular arrhythmias or resuscitated cardiac arrest. The primary endpoint will be analyzed according to the intention-to-treat principle. Conclusion The REBOOT trial will provide robust evidence to guide the prescription of β-blockers to patients discharged after MI without reduced LVEF.

Objetivo: Determinar parámetros visuales sencillos para la evaluación de características esqueletales relacionadas con el biotipo facial en una telerradiografía lateral. Material y método: Estudio transversal descriptivo. Se confeccionó una guía visual impresa acerca de ocho características morfológicas del esqueleto facial visibles en la telerradiografía de perfil. Ésta fue entregada a un grupo de 69 estudiantes de Odontología de 5º año sin estudios previos en cefalometría, quienes la analizaron durante 10 minutos. Inmediatamente se les mostraron una serie de telerradiografías, y se les pidió que evaluaran las 8 características a través de una serie de opciones presentadas en una escala visual que se correspondía con la guía estudiada. Las respuestas fueron registradas utilizando un sistema digital de cliqueras. Los datos fueron analizados con el método Rasch para determinar la dificultad de los ítems, estableciéndose el grado de dificultad a través del Logit. Resultados: Los estudiantes lograron identificar y graduar sin dificultad 5 de las 8 características presentadas. Éstas fueron: Proyección del mentón (-2,49), Divergencia facial (-2,85), Ancho de la rama mandibular (-1,97), Escotadura sigmoidea (-0,96) y Relación de la rama con el cuerpo mandibular (-0,06). Conclusión: Se determinó que hay 5 características de la morfología ósea facial relacionadas con el biotipo que se pueden identificar y graduar sin dificultad por estudiantes de pregrado de odontología. Ésta información podría ser utilizada para construir una escala sencilla de identificación del biotipo facial. ABSTRACTAim: Determine simple visual parameters to evaluate skeletal characteristics related to facial types in lateral teleradiographs. Materials and Methods: Descriptive crosssectional study. A printed visual guideline about the eight visible morphological characteristics of the facial skeleton in cephalometric x-rays was created. The guideline was given to 69 undergraduate dental students (fifth year) without previous studies in cephalometric to analyze it for 10 minutes. Immediately after, they were shown a series of teleradiographs and were asked to evaluate 8 characteristics through a series of options presented in a visual scale according to the guideline. The answers were recorded through a digital audience response system (clickers). The data obtained were analyzed with the Rasch method to assess each item level of difficulty, establishing the Logit number for each one. Results: The students identified and graded without difficulty 5 of the 8 characteristics. These were: Chin projection (-2.49), Facial divergence (-2.85), Mandibular ramus width (-1.97), Sigmoid notch (-0.96) and Mandibular body with ramus relationship (-0.06). Conclusions: Five facial osseous morphological characteristics related to the facial types can be identified and graded without difficulty by undergraduate dental students. This information may be used to create a facial type identification scale.

Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver disease. The clinical presentation is unspecific, with symptoms ranging from abdominal pain, malaise, and weight loss to atypical manifestation which include hyperammonemic encephalopathy. We present the case of a 33-year-old woman with no prior medical history who presented with a coma and a diagnosis of inoperable fibrolamellar hepatocarcinoma requiring a cadaver donor transplant. While she was on the waiting list, she received hemofiltration and ammonium benzoate treatment, with progressive improvement in her state of consciousness.