Background Internet-based Cognitive Behavioural Therapy (iCBT) is found effective in treating common mental disorders. However, the use of these interventions in routine care is limited. The international ImpleMentAll study is funded by the European Union’s Horizon 2020 programme. It is concerned with studying and improving methods for implementing evidence-based iCBT services for common mental disorders in routine mental health care. A digitally accessible implementation toolkit (ItFits-toolkit) will be introduced to mental health care organizations with the aim to facilitate the ongoing implementation of iCBT services within local contexts. This study investigates the effectiveness of the ItFits-toolkit by comparing it to implementation-as-usual activities. Methods A stepped wedge cluster randomized controlled trial (SWT) design will be applied. Over a trial period of 30 months, the ItFits-toolkit will be introduced sequentially in twelve routine mental health care organizations in primary and specialist care across nine countries in Europe and Australia. Repeated measures are applied to assess change over time in the outcome variables. The effectiveness of the ItFits-toolkit will be assessed in terms of the degree of normalization of the use of the iCBT services. Several exploratory outcomes including uptake of the iCBT services will be measured to feed the interpretation of the primary outcome. Data will be collected via a centralized data collection system and analysed using generalized linear mixed modelling. A qualitative process evaluation of routine implementation activities and the use of the ItFits-toolkit will be conducted within this study. Discussion The ImpleMentAll study is a large-scale international research project designed to study the effectiveness of tailored implementation. Using a SWT design that allows to examine change over time, this study will investigate the effect of tailored implementation on the normalization of the use of iCBT services and their uptake. It will provide a better understanding of the process and methods of tailoring implementation strategies. If found effective, the ItFits-toolkit will be made accessible for mental health care service providers, to help them overcome their context-specific implementation challenges. Trial registration ClinicalTrials.gov NCT03652883. Retrospectively registered on 29 August 2018

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The Suzuki−Miyaura reaction is presented as a versatile procedure for the synthesis of a small library of highly electron‐rich 2‐[4,5‐dimethoxy‐2‐(hetero)arylphenyl]ethylamines. Microwave‐irradiation accelerates the reaction tremendously and furnishes superior yields. The difficult oxidative addition of the catalyst to a highly electron‐rich and ortho‐substituted system could be performed easily, and the proto‐deboronation during cross‐coupling reactions involving the highly electron‐withdrawing (2‐formylphenyl)boronic acid could be minimized. Enhanced yields and complete compatibility with aqueous conditions were found. This strategy was developed en route towards the synthesis of an apogalanthamine analogue. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

Microwave-assisted solid-phase Diels−Alder cycloaddition reactions of 2(1H)-pyrazinones with dienophiles are discussed. Separation of the resulting pyridines from the pyridinone byproducts was achieved by applying a traceless-linking concept, whereby the pyridinones remain on the solid support with concomitant release of the pyridine products to solution. As a model study, Wang linker was mimicked in solution using a 4-methoxybenzyl group at the N1 position of the 2(1H)-pyrazinone. The sequence was successfully carried out in solution under conventional thermal heating conditions as well as utilizing high-speed microwave irradiation. The results were adapted to polystyrene supports, using various different acid labile linkers, such as Wang resin, HMPB-AM resin, and a novel, tailor-made acid-labile linker based on syringaldehyde, which has been proven in terms of cleavage rates to be superior to both the standard Wang and HMPB-AM linkers. All steps in the solid-phase protocol (linking, cycloaddition, cleavage) were carried out under both thermal and controlled microwave irradiation conditions. In general, significant rate enhancements were found for reactions carried out under high-temperature microwave conditions, reducing reaction times from hours or days to minutes.