As the MPV value is included in the complete blood count (CBC) analysis, it increases the sensitivity and NPVs of white blood cell (WBC) in AA diagnosis without the need for extra analyses, loss of time, or cost increase. Therefore, we believe that the MPV value should also be taken into consideration along with the WBC in every patient with suspected AA.

Amaç: Bu çalışmada benign ön tanılarla yapılan histerektomilerin, endikasyonlar ve histopatolojik tanılar açısından değerlendirilmesi amaçlandı. Yöntem: Ocak 2011 ile Aralık 2012 yılları arasında yapılmış olan 258 histerektomi olgusu endikasyonlar ve histopatolojik tanılar açısından retrospektif olarak değerlendirildi. Bulgular: En sık histerektomi endikasyonu anormal uterin kanama idi 87 (%33,72). Daha sonra sırası ile myoma uteri 73 (%28,29) ve endometrial hiperplazi 67 (%25,96) olarak tespit edildi. Diğer klinik endikasyonlar adenomyozis 25 (% 9,68) ve uterus prolapsusu 6 (% 2,32) idi. Histerektomi materyallerinin histopatolojik raporları incelendiğinde, en yaygın patoloji leiomyoma 83 (%32,17), takiben adenomyozis 78 (% 30,23) ve endometrial hiperplazi 77(29,84) idi. Endometrial polip 13 (% 5,04) vakada tespit edildi. 7 (% 2,71) vakada ise atrofik endometrium mevcuttu. Yine histerektomi materyallerinin serviks incelemelerinde olguların % 54,26'sında kronik servisit olduğu gözlendi. Sonuç: Myoma uteri ile endometrial hiperplazilerin yüksek oranda birlikteliği nedeniyle myoma uteri tanısıyla histerektomi planlanan hastalarda menometrorajide mevcutsa mutlaka endometrial örnekleme de yapılmalıdır.Objective: To evaluate hysterectomy procedures performed for benign conditions in terms of indications and histopathological results. Method: Retrospective analysis of 258 hysterectomy cases, which were performed between January 2011 and December 2012, was conducted to review indications and histopathological diagnoses. Results: The most frequent indications for hysterectomy were abnormal uterine bleeding 87, (33,72%), myoma uteri 73, (28,29%) and endometrial hyperplasia 67, ( 25,96%), respectively. Other clinical indications were adenomyosis 25, ( 9,68%) and uterine prolapse 6, (2,32%). The most common histopathological diagnoses reported for hysterectomy specimens were leiomyoma 83, (32,17%), adenomyosis 78, (30,23%) and endometrial hyperplasia 77 (29,84%), respectively. Endometrial polyp was diagnosed in specimens of 13 patients (5,04%). Endometrial atrophy was reported in 7 patients ( 2,71%). Cervical histopathology of hysterectomy materials revealed chronic cervicitis in 54,26% of the patients. Conclusion: Due to the high coincidence of myoma uteri and endometrial hyperplasia, endometrial sampling should be performed in patients who are being considered for hysterectomy for myoma uteri and also have menometrorrhagia.Anahtar Kelimeler: Histerektomi, Endikasyon, Patoloji.

No abstract

The thyroglossal duct cyst is the most common developmental anomaly of the thyroid gland. We present a patient with a papillary thyroid carcinoma diagnosed after surgical resection of a thyroglossal cyst. The 39-year-old patient reported to our hospital due to a swelling of this throat. The results of the ultrasonography were reported as showing multiple nodules in both thyroid lobes, and an ~3-cm diameter image in the submental area, in keeping with lymphadenomegalia. In the fine-needle aspiration cytology (FNAC) evaluation from the nodules in the thyroid, it was observed that the thyrocites with uniform nuclei made up single-layer groups. FNAC from the thyroglossal cyst, a few histiocytes were observed on a ground with a large number of erythrocytes. The patient was subjected to a total thyroidectomy, pyramidal lobe excision, and total excision of the 3-cm diameter soft mass, starting at the tip of the pyramidal lobe. The case was diagnosed as papillary thyroid carcinoma in thyroglossal duct cyst with histopathological and immunohistochemical findings. If the thyroglossal channel cyst had been diagnosed preoperatively, total thyroidectomy and a Sistrunk operation would have been performed. For this reason, repeated FNAC, particularly, if performed under ultrasound guidance, may improve the diagnostic value of FNAC. Thus, in such patients, throat ultrasonography must be carried out in expert hands, thin-needle aspiration biopsy, computerized tomography, and thyroid scintigraphy must be done if necessary, and the necessary treatment protocols carried out after a definite diagnosis.

The ability of amiodarone to prevent pathological changes and oxidative stress after isoproterenol (ISO)-induced myocardial injury was investigated in rats. A better understanding of the processes involved in the pathophysiology of myocardial infarction has led to the search for drugs that can limit the extent of myocardial injury. Amiodarone was administered to groups of rats once per day for 30 days. On days 29 and 30, the rats of the ISO control and drug treatment groups were administered 180 mg/kg ISO subcutaneously at an interval of 24 h for two consecutive days. In the control groups, clinical indicators, such as creatine kinase-isoenzymes and troponin-I, were found to be statistically higher than in the drug groups. Parallel to this increase in indicators, a significant decrease in glutathione levels and activities of superoxide dismutase and an increase in malondialdehyde level were detected. Biochemical and histopathologic results in the ISO-induced model of myocardial injury emphasize the beneficial action of amiodarone as a cardioprotective agent.