The month of Ramadan, the 9 th month of the Islamic lunar calendar, is a holy month in the Muslim religion. During this period, Muslims must fast from dawn until sunset. The Holy Qur'an specifically exempts people with a medical reason from observing the fast, especially if this can have negative consequences on their health. [1] During the fasting, diabetic patients, because of their pathology, are exposed to an increased risk of hypoglycemia, loss of diabetes control, dehydration (especially in summer) and thromboembolic complications. Also, there are disturbances of chronobiology due to a change in the daily rhythm, marked by frequent disturbances in sleep, and a nocturnal diet. Because of all this, it is recommended for patients with T2DM who are uncontrolled, unstable, or have diabetes-related complications to avoid fasting. [1,2] Some patients proceed with fasting despite their physician's disagreement and the presence of a religious exemption. [1] We aimed to study the consequences of fasting and changes in eating habits on certain clinical and biological parameters in a group of diabetic patients compared to a control group and to derive some recommendations based on the results obtained. suBjEcts and MEthods Study designWe conducted an observational, descriptive and comparative study. We included 31 subjects divided into two groups: group 1 composed of 15 patients with T2DM, recruited from patients attending the National Institute of Nutrition in

Allergy to insulin became a rare complication due to the introduction of recombinant human insulin preparations. Nevertheless, allergic reactions to components of such preparations can occur. We report a case of a 61-year-old man with an atopic background and affected by diabetes mellitus type 2 since 27 years, who experienced generalized allergy to insulin at the moment of switching oral anti-diabetics to insulin. Prick tests revealed an allergy specifically to zinc, and the patient was treated with zinc-free glulisine insulin. After 8 months of such treatment, patient's glucose is stable and he never experienced allergic reactions to insulin injections. Even insulin allergy due specifically to zinc is rare, such complication must be assessed especially in a patient suffering from multiple allergies.

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