Background Several techniques have been described for placement of inflatable penile prostheses (IPP) reservoirs, with variable satisfaction. Standard placement in the Space of Retzius can present with several complications and may be technically difficult in patients with a violated space. Concerns with ectopic reservoir placement have included reservoir herniation and lack of reservoir concealability. Aim To present a novel technique to achieve reservoir concealment with decreased postoperative complications as an alternative to standard approaches of ectopic reservoir placement. Methods We describe our novel low submuscular reservoir (LSM) placement with transfascial fixation (TFF) for inflatable penile prostheses. Outcomes Patient satisfaction with reservoir concealment, complication rate or need for additional surgeries. Results A total of 31 cases successfully underwent our technique. The low submuscular placement with TFF of the IPP reservoir offers an optimal approach for reservoir placement with a high degree of patient satisfaction with significant ease of placement compared to alternative methods. Clinical Implications Penile prosthetic surgeons should be familiar with several techniques for concealment of reservoir as an option to improve patient satisfaction. Strengths and Limitations Given the small sample size of patients who have undergone this novel technique, current literature regarding the topic is limited. Conclusion Low submuscular reservoir placement with transfascial fixation for IPPs is a technically feasible approach that can be employed to achieve patient satisfaction and decrease the risk of reservoir herniation.

<p>FOXA1 peaks in MCF7 cells expressing lacZ or EN1-V5.</p>

<p>List of genes differentially expressed in MCF7 cells expressing EN1-V5.</p>

<p>List of genes differentially expressed in SUM159 cells expressing shNLGN4X.</p>