A planar trimeric macrocyclic oligoamide of 8-amino-2-quinoline carboxylic acid, bearing ammonium side chains, stabilizes the human telomeric G-quadruplex more strongly than the potent ligand telomestatin. Furthermore, a helical oligoamide tetramer also binds strongly to G-quadruplexes and is a new structural class of quadruplex ligand that appears to interact enantioselectively.
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