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Abstract. The multipole response of neutron rich O and Sn isotopes is computed in Tamm-Dancoff and random-phase approximations using the canonical Hartree-Fock-Bogoliubov quasi-particle basis. The calculations are performed using an intrinsic Hamiltonian composed of a V lowk potential, deduced from the CD-Bonn nucleon-nucleon interaction, corrected with phenomenological density dependent and spin-orbit terms. The effect of these two pieces on energies and multipole responses is discussed. The problem of removing the spurious admixtures induced by the center of mass motion and by the violation of the number of particles is investigated. The differences between the two theoretical approaches are discussed quantitatively. Attention is then focused on the dipole strength distribution, including the low-lying transitions associated to the pygmy resonance. Monopole and quadrupole responses are also briefly investigated. A detailed comparison with the available experimental spectra contributes to clarify the extent of validity of the two self-consistent approaches. ‡ present address : Ecole Normale Superieur (ENS) de Cachan, 61 av. du Président Wilson, Cachan -France Self-consistent study of multipole response in neutron rich nuclei using a modified realistic potential2

BackgroundThe independent prognostic impact of diabetes mellitus (DM) and prediabetes mellitus (pre‐DM) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre‐DM on survival outcomes in the GISSI‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) trial.Methods and ResultsWe assessed the risk of all‐cause death and the composite of all‐cause death or cardiovascular hospitalization over a median follow‐up period of 3.9 years among the 6935 chronic heart failure participants of the GISSI‐HF trial, who were stratified by presence of DM (n=2852), pre‐DM (n=2013), and non‐DM (n=2070) at baseline. Compared with non‐DM patients, those with DM had remarkably higher incidence rates of all‐cause death (34.5% versus 24.6%) and the composite end point (63.6% versus 54.7%). Conversely, both event rates were similar between non‐DM patients and those with pre‐DM. Cox regression analysis showed that DM, but not pre‐DM, was associated with an increased risk of all‐cause death (adjusted hazard ratio, 1.43; 95% CI, 1.28–1.60) and of the composite end point (adjusted hazard ratio, 1.23; 95% CI, 1.13–1.32), independently of established risk factors. In the DM subgroup, higher hemoglobin A1c was also independently associated with increased risk of both study outcomes (all‐cause death: adjusted hazard ratio, 1.21; 95% CI, 1.02–1.43; and composite end point: adjusted hazard ratio, 1.14; 95% CI, 1.01–1.29, respectively).ConclusionsPresence of DM was independently associated with poor long‐term survival outcomes in patients with chronic heart failure.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00336336.

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